DRSC/TRiP Functional Genomics Resources

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Protein Alignment Csk and Abl2

DIOPT Version :9

Sequence 1:NP_001262476.1 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_033725.2 Gene:Abl2 / 11352 MGIID:87860 Length:1182 Species:Mus musculus


Alignment Length:563 Identity:195/563 - (34%)
Similarity:283/563 - (50%) Gaps:67/563 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   501 QQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGG-----AG 560
            ||.....|..:.|..|:.....|||..:.||.....       |..|   .|:|...|     .|
Mouse    15 QQPQPRGIRGSSAARPSGRRRDPAGRTADAGFNVFT-------QHDH---FASCVEDGFEGDKTG 69

  Fly   561 LMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMS 625
            ..|..:.....|.....:|| .:::..|..:   |:|..|...|                  .:.
Mouse    70 GSSPEVLHRPFGCDAESQAL-NEAIRWSSKE---NLLGATESDP------------------NLF 112

  Fly   626 TSLHSFDING-----VTAGS-----GVNASSAWSSGSTTAMNHASLSPT-ALAPQQGRSRCEVKL 679
            .:|:.|..:|     :|.|.     |.|.:..||  ...:.|.....|: .:.|..       .|
Mouse   113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWS--EVRSKNGQGWVPSNYITPVN-------SL 168

  Fly   680 NAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVK-YLENKLTID 743
            ....|:||.::|..||:||....:|.||||||.:.||..::.:.::.:|.|||:. ..::|:.:.
Mouse   169 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTTDSKVYVT 233

  Fly   744 DEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGK 808
            .|..|..|.:||.|:...||||.|.|....||..|.  .:.....:...|.:...::.::..:|.
Mouse   234 AESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKP--TVYGVSPIHDKWEMERTDITMKHKLGG 296

  Fly   809 GEFGDVMLGILRNEK--VAVKMLK-DEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVT 870
            |::|:|.:|:.:...  ||||.|| |...|::||.||:||..::|.|||:.:|:.......|:||
Mouse   297 GQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVT 361

  Fly   871 EYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVS 935
            |||..|:|:||||...|:.:|....:..|...:|.|||||.|..:||||||||.|:.|:.|.||:
Mouse   362 EYMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVA 426

  Fly   936 DFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPL 996
            ||||:|   .:.|....| |.||||||||:|....||.|||:|:||:|||||.::|..|||.|.|
Mouse   427 DFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDL 491

  Fly   997 ADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAE 1039
            :.|...:|.||:||.||||||::||:||..|..:||.||:|||
Mouse   492 SQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_001262476.1 SH2_csk_like 680..777 CDD:198190 36/97 (37%)
PTKc_Csk_like 793..1047 CDD:270635 120/254 (47%)
STYKc 800..1044 CDD:214568 119/247 (48%)
Abl2NP_033725.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42 8/26 (31%)
CAP 2..106 23/104 (22%)
SH3_Abl 111..164 CDD:212784 11/54 (20%)
SH2_ABL 169..262 CDD:198189 34/92 (37%)
PTKc_Abl 281..543 CDD:270645 120/254 (47%)
STYKc 288..539 CDD:214568 119/247 (48%)
Kinase activation loop. /evidence=ECO:0000250 427..451 10/23 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..642
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..674
Nuclear localization signal. /evidence=ECO:0000255 659..661
F-actin-binding 695..930
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 765..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 809..858
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1059
F-actin-binding 1020..1182
FABD 1063..1182 CDD:197885
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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