DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and Abl1

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001106174.1	Gene:	Abl1 / 11350	MGIID:	87859	Length:	1142	Species:	Mus musculus

Alignment Length:	485	Identity:	182/485 - (37%)
Similarity:	267/485 - (55%)	Gaps:	44/485 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 GSQHGSNMLLHTAPQPPQAS--QPAAVVGVSGSGS-----AGMS-------TSLHSFDING---- 635
            |..|.:..:.|.|.|.|.||  :|..:...:...|     ||.|       .:|:.|..:|
Mouse    35 GGPHCNVFVEHEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTL 99

  Fly   636 -VTAGS-----GVNASSAWSSGSTTAMNHASLSPT-ALAPQQGRSRCEVKLNAMPWFHGSITRDE 693
             :|.|.     |.|.:..|....|  .|.....|: .:.|..       .|....|:||.::|:.
Mouse   100 SITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYITPVN-------SLEKHSWYHGPVSRNA 155

  Fly   694 AEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYL-ENKLTIDDEEYFENLGQLVAH 757
            ||:||....:|.||||||.:.||..::.:.::.:|.|||:... :.||.:..|..|..|.:||.|
Mouse   156 AEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHH 220

  Fly   758 YEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE 822
            :...||||.|.|....||..|......|.:: || |.:...::.::..:|.|::|:|..|:.:..
Mouse   221 HSTVADGLITTLHYPAPKRNKPTIYGVSPNY-DK-WEMERTDITMKHKLGGGQYGEVYEGVWKKY 283

  Fly   823 K--VAVKMLK-DEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRS 884
            .  ||||.|| |...|::||.||:||..::|.|||:.:|:.......|::||:|:.|:|:||||.
Mouse   284 SLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRE 348

  Fly   885 RGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYN 946
            ..||.::....:..|...:|.|||||.|..:||||||||.|:.|:.:.||:||||:|   .:.|.
Mouse   349 CNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYT 413

  Fly   947 LDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKME 1010
            ...| |.||||||||:|...:||.|||:|:||:|||||.::|..|||.|.|:.|.:.:|..|:||
Mouse   414 AHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRME 478

  Fly  1011 APEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            .|||||.::||:||..|..||:.||:|||:
Mouse   479 RPEGCPEKVYELMRACWQWNPSDRPSFAEI 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	37/97 (38%)
		PTKc_Csk_like	793..1047	CDD:270635	115/255 (45%)
		STYKc	800..1044	CDD:214568	114/248 (46%)
Abl1	NP_001106174.1	SH3_Abl	84..137	CDD:212784	11/54 (20%)
		SH2_ABL	142..235	CDD:198189	35/92 (38%)
		PTKc_Abl	254..516	CDD:270645	115/255 (45%)
		Pkinase_Tyr	261..512	CDD:285015	114/248 (46%)
		FABD	1018..1142	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910