DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and lck

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_012812855.2	Gene:	lck / 100497656	XenbaseID:	XB-GENE-6054021	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	387	Identity:	161/387 - (41%)
Similarity:	230/387 - (59%)	Gaps:	31/387 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 WFHGSITRDEAE-HLLQP-REDGLFLVRESTNFPGDYTLCV--CFQSK---VEHYRVKYLEN-KL 740
            ||...:.|.:|| .||.| .:.|.||||||....|.|:|.|  ..|::   |:||:::.|:| ..
Frog   121 WFFRDLGRKDAERQLLAPGNQQGSFLVRESETTKGSYSLSVRDLDQNQGEVVKHYKIRNLDNGGF 185

  Fly   741 TIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKD----FVDKGWVIPEAELQ 801
            .|...:.|:.|.:||.||...:|||||.|         :|.|...:.    :.|: |.||..:||
Frog   186 YISPRKTFQTLQELVQHYRRSSDGLCTLL---------KEPCQTQRPQKPWWADE-WEIPRNKLQ 240

  Fly   802 LRESIGKGEFGDVMLGILR-NEKVAVKMLKDEGAV--QKFLAEASVMTTLEHDNLVKFIGLVFTS 863
            |.:.:|.|:||:|.:|... :.|||:|.|| .|.:  :.|||||::|..|:|..||: :..|.|.
Frog   241 LVKKLGAGQFGEVWMGYYNGHTKVAIKSLK-PGTMSPEAFLAEANLMKQLQHPRLVR-LNAVVTQ 303

  Fly   864 KHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISE 928
            :.:|:|||||.||.|||||::.....:|....|..:...|.||.:||.|..:||||.|.|:|:||
Frog   304 EPIYIVTEYMEKGCLVDYLKTSEGLKLTIYKLIDMSAQVAEGMAFLEHKNYIHRDLRAANILVSE 368

  Fly   929 DCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRV 989
            ....|::||||||   :..|....| |.|||||||||:..|.|:.|||:||||:||.||.::||:
Frog   369 SLCCKIADFGLARVIVDNEYTAKEGAKFPIKWTAPEAINYGTFTIKSDVWSFGVLLTEIVTYGRI 433

  Fly   990 PYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNAT 1051
            |||.:...:|::::|.||:|..|:.||.|:||:|.:.|...|.:||||..|:..|:....||
Frog   434 PYPGMTNPEVIENLERGYRMPQPDNCPMELYELMLRCWKEEPEERPTFEFLRSLLEDFFTAT 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	38/100 (38%)
		PTKc_Csk_like	793..1047	CDD:270635	118/260 (45%)
		STYKc	800..1044	CDD:214568	114/250 (46%)
lck	XP_012812855.2	SH3_Lck	59..112	CDD:212938
		SH2_Src_family	117..217	CDD:199827	38/104 (37%)
		PTKc_Lck_Blk	231..494	CDD:270652	118/265 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920