Protein Alignment Csk and ret

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_012822323.2
• Gene: ret / 100495902
• XenbaseID: XB-GENE-485176
• Length: 1102
• Species: Xenopus tropicalis
• Alignment Length: 312
• Identity: 110/312 - (35%)
• Similarity: 165/312 - (52%)
• Gaps: 40/312 - (12%)

  Fly   774 PKLGKQEFCINSKDF---VDKGWVIPEAELQLRESIGKGEFGDV-------MLGILRNEKVAVKM 828
            |.|...|..::...|   .|..|..|...|.|.:::|:||||.|       :.|......|||||
 Frog   683 PSLDSMENQVSVDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKM 747

  Fly   829 LKD---EGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGR--- 887
            ||:   :..::..|:|.:::..:.|.:::|..|.......|:|:.||...|||..:||...:
 Frog   748 LKESASQSELRDLLSEFNLLKQVNHPHVIKLYGACTQDGPLHLIVEYAKYGSLRSFLRESRKVGP 812

  Fly   888 -------------------QHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAK 933
                               :.:|..|.|.||:..:.||:||...|:|||||||||||::|....|
 Frog   813 SSLGGDSNRNSSYLDNPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMK 877

  Fly   934 VSDFGLAR----EECY-NLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPR 993
            :|||||:|    |:.| ....|::|:||.|.|:|.:..::.:||:||||:|||||.:.|..|||.
 Frog   878 ISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG 942

  Fly   994 IPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQ 1045
            |....:...::.||:||.||.|..|:|.:|.:.|...|.|||||.|:..:|:
 Frog   943 IAPERLFNLLKTGYRMEKPENCSDEMYNLMLKCWKQEPDKRPTFGEISKELE 994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	1/2 (50%)
		PTKc_Csk_like	793..1047	CDD:270635	105/290 (36%)
ret	XP_012822323.2	RET_CLD1	20..140	CDD:465485
		CA_like	160..242	CDD:481204
		RET_CLD3	252..368	CDD:465516
		RET_CLD4	392..494	CDD:465517
		PTKc_RET	711..1000	CDD:173631	103/284 (36%)