Protein Alignment Csk and LOC100491469

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_031750439.1
• Gene: LOC100491469 / 100491469
• XenbaseID: XB-GENE-29080711
• Length: 489
• Species: Xenopus tropicalis
• Alignment Length: 443
• Identity: 145/443 - (32%)
• Similarity: 216/443 - (48%)
• Gaps: 59/443 - (13%)

  Fly   577 ERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDING---VTA 638
            :|..|||.         |.:.:.|.....|.:.|:....|         |:|:||:...   :|.
 Frog    17 DRIWPPKR---------SGVYVSTVDLVIQDNYPSRTDRV---------TALYSFNARSTHELTI 63

  Fly   639 GSGVNASSAWSSG------STTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHL 697
            ..|.........|      ..|....:.|.|.:...|.........:.. ||:....:|::||.|
 Frog    64 EQGEELCMISDEGEYILARKLTGNMESGLVPASYVAQSSLPGGHYTIQE-PWYMEVASRNDAERL 127

  Fly   698 L--QPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVK-------YLENKLTIDDEEYFENLGQ 753
            |  .|...|.||||.|.:.||.|:|.|..:.||.|:.:.       |::|      |:.|.::.:
 Frog   128 LFSSPNAHGSFLVRPSDSTPGHYSLSVRNEDKVSHFCISVSPGGQFYIQN------EKVFASIEK 186

  Fly   754 LVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGI 818
            ||..|:.:     .:|||. |.|....:....:|    .|..|.:|.:|...:|.|.||:|..|:
 Frog   187 LVNFYKTN-----WKLIKS-PLLKPCVWVAYQRD----QWERPRSEFKLVRQLGAGNFGEVWEGL 241

  Fly   819 LRN-EKVAVKMLKDEGAVQK-FLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDY 881
            ..| :|||:|..|.:...:. |..|.:.:.||.|.||::...:....:.:|:|||.||||||:.:
 Frog   242 WNNKDKVAIKTFKQDNINESDFKKEVNALKTLCHKNLIQLYAVCSVGEPVYIVTELMSKGSLLQF 306

  Fly   882 LRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EE 943
            ||....:|:|....:......|.||.:||.:.||||||||||||:.|..|.||:||||||   ::
 Frog   307 LRGTEGRHLTAGSFMHIISQVAEGMVFLEKEHVVHRDLAARNVLVGEKLVCKVADFGLARILKDD 371

  Fly   944 CYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIP 995
            .|:|... |:||||||||.|....:|.|||:||:||:::|:|..|::||...|
 Frog   372 LYSLQGNIKIPIKWTAPEVLTRSIYSTKSDVWSYGIVMYEVYMLGQMPYQGEP 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	33/105 (31%)
		PTKc_Csk_like	793..1047	CDD:270635	90/209 (43%)
LOC100491469	XP_031750439.1	SH3_Srms	46..100	CDD:212780	11/62 (18%)
		SH2	113..191	CDD:472789	28/83 (34%)
		Protein Kinases, catalytic domain	216..>422	CDD:473864	89/205 (43%)