DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and ptk6

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_002942429.3	Gene:	ptk6 / 100490792	XenbaseID:	XB-GENE-22069031	Length:	563	Species:	Xenopus tropicalis

Alignment Length:	381	Identity:	136/381 - (35%)
Similarity:	210/381 - (55%)	Gaps:	24/381 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 WFHGSITRDEAEHLL--QPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRV-KYLENKLTIDDE 745
            ||.|..:|.||.:||  :...:|.||:|.|......|.|.|..|....|::: :..|.:..:::.
Frog   170 WFFGEKSRTEAVNLLMDEGNTNGSFLIRASDKHGILYVLSVRHQDSTRHFKIMRNPEGQFHLNNM 234

  Fly   746 EYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVD-------KGWVIPEAELQLR 803
            .:|.:|.|||..|       |.:.| | |.|...:.|:.::..|.       ..|..|..|..|.
Frog   235 TFFPDLKQLVETY-------CKKPI-C-PGLTLTKPCVKNEPVVSDLSPVPLDEWERPREEFTLV 290

  Fly   804 ESIGKGEFGDVMLGILRNE-KVAVKMLKDEGAVQK-FLAEASVMTTLEHDNLVKFIGLVFTSKHL 866
            :.:|.|.||.|..|:.:.: |||||.:|.:...|. |:.|.:.:.||.|.||:....:.......
Frog   291 KRLGMGNFGQVHEGLWKGKLKVAVKTIKRDATSQDLFVKETAFLKTLHHKNLLSLYAVCSVGDPY 355

  Fly   867 YLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCV 931
            |:|||.:.:|.|::|||...:..:..:.|:..|...|.||.|||::..:||||||||||:..:.:
Frog   356 YIVTELVPRGDLLNYLRDLEKDELDVEGQLDIATQVAEGMRYLESQNCIHRDLAARNVLMGRNNI 420

  Fly   932 AKVSDFGLARE--ECYNLDVGK-LPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPR 993
            .|::|||:||.  :.|.:...| :|.|||||||::.||::.|||:|||||||:||.|.|..|||.
Frog   421 CKIADFGMARVILDSYYVSASKEIPFKWTAPEAVEYGRYTVKSDVWSFGILLYEIMSLGMQPYPA 485

  Fly   994 IPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNN 1049
            :...:|::.:..|.:|:||..|...:|.:|...|..||.:||:|.:|:..|:.|:|
Frog   486 LSNYEVLEFLNRGQRMKAPPSCSTRVYNIMLTCWAWNPNERPSFDDLRTMLENLSN 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	29/95 (31%)
		PTKc_Csk_like	793..1047	CDD:270635	102/258 (40%)
		STYKc	800..1044	CDD:214568	98/248 (40%)
ptk6	XP_002942429.3	SH3	104..161	CDD:418401
		SH2	168..252	CDD:214585	26/88 (30%)
		STYKc	288..536	CDD:214568	98/247 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920