DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and frk

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_002938349.1	Gene:	frk / 100488362	XenbaseID:	XB-GENE-492884	Length:	517	Species:	Xenopus tropicalis

Alignment Length:	415	Identity:	158/415 - (38%)
Similarity:	237/415 - (57%)	Gaps:	36/415 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   658 HASLSPTALAPQQGRSRCEVKLN---------AMPWFHGSITRDEAEHLL-QP-REDGLFLVRES 711
            |||.....|...:|::...|..|         :||||...|.|.|||.|| :| ...|.||:|||
Frog    94 HASWWKAKLLRTRGKAEGYVPFNYVAPVSSIESMPWFFKDIKRSEAERLLVRPGNTTGSFLIRES 158

  Fly   712 TNFPGDYTLCVCFQSKVEHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLIK-C-- 772
            .:..|:|:|.|.....|:|||::.|:: ...|..:..|.::.:||.:|....:|||.:|:| |
Frog   159 ESQKGEYSLSVFDGIAVKHYRLRKLDDGGFYITSKSKFVSMNELVEYYGKREEGLCCKLLKPCIT 223

  Fly   773 ----LPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKDE 832
                ||    .:.|.::.|.    |.|....|:..:.:|:|:||:|..|:..|. .||:|.|| .
Frog   224 TGIPLP----PDLCYHTADH----WEINRNSLKFLKKLGQGQFGEVWEGLWNNTIPVAIKTLK-T 279

  Fly   833 GAV--QKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQ 895
            |.:  |.||.||..|..|.|..|::...:....:.:|::||.|..|||:.||::.....|...:|
Frog   280 GTMNPQDFLREAQFMKNLRHPKLIQLQAVCTLEEPVYIITELMRHGSLLSYLQNDNGTSIHIPNQ 344

  Fly   896 IIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR----EECYNL-DVGKLPIK 955
            :..|...||||.|||.:..:||||||||||:.|:.|.||:||||||    |:.|.. :..|||:|
Frog   345 VDMAAQVASGMAYLETQSFIHRDLAARNVLVGENGVYKVADFGLARVFKGEDVYEAKNDTKLPLK 409

  Fly   956 WTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIY 1020
            ||||||::..||:.|||:|:||||::||.::|::|||.:.....:..:|.||::..|..||.::|
Frog   410 WTAPEAIRYNRFTIKSDVWAFGILIFEIVTYGKMPYPGLTGRQALDKLENGYRIPKPFNCPHDLY 474

  Fly  1021 EMMRQAWDLNPAKRPTFAELKVKLQ 1045
            ::|.:.|:..|.:||||..|:.||:
Frog   475 KIMLECWNAKPEERPTFETLQWKLE 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	41/115 (36%)
		PTKc_Csk_like	793..1047	CDD:270635	109/261 (42%)
		STYKc	800..1044	CDD:214568	105/251 (42%)
frk	XP_002938349.1	SH3_Src_like	65..117	CDD:212779	6/22 (27%)
		SH2	125..220	CDD:387587	36/94 (38%)
		PTKc_Frk_like	238..505	CDD:270653	110/267 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920