Protein Alignment Csk and frk

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_002938349.1
• Gene: frk / 100488362
• XenbaseID: XB-GENE-492884
• Length: 517
• Species: Xenopus tropicalis
• Alignment Length: 415
• Identity: 158/415 - (38%)
• Similarity: 237/415 - (57%)
• Gaps: 36/415 - (8%)

  Fly   658 HASLSPTALAPQQGRSRCEVKLN---------AMPWFHGSITRDEAEHLL-QP-REDGLFLVRES 711
            |||.....|...:|::...|..|         :||||...|.|.|||.|| :| ...|.||:|||
 Frog    94 HASWWKAKLLRTRGKAEGYVPFNYVAPVSSIESMPWFFKDIKRSEAERLLVRPGNTTGSFLIRES 158

  Fly   712 TNFPGDYTLCVCFQSKVEHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLIK-C-- 772
            .:..|:|:|.|.....|:|||::.|:: ...|..:..|.::.:||.:|....:|||.:|:| |
 Frog   159 ESQKGEYSLSVFDGIAVKHYRLRKLDDGGFYITSKSKFVSMNELVEYYGKREEGLCCKLLKPCIT 223

  Fly   773 ----LPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKDE 832
                ||    .:.|.::.|.    |.|....|:..:.:|:|:||:|..|:..|. .||:|.|| .
 Frog   224 TGIPLP----PDLCYHTADH----WEINRNSLKFLKKLGQGQFGEVWEGLWNNTIPVAIKTLK-T 279

  Fly   833 GAV--QKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQ 895
            |.:  |.||.||..|..|.|..|::...:....:.:|::||.|..|||:.||::.....|...:|
 Frog   280 GTMNPQDFLREAQFMKNLRHPKLIQLQAVCTLEEPVYIITELMRHGSLLSYLQNDNGTSIHIPNQ 344

  Fly   896 IIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR----EECYNL-DVGKLPIK 955
            :..|...||||.|||.:..:||||||||||:.|:.|.||:||||||    |:.|.. :..|||:|
 Frog   345 VDMAAQVASGMAYLETQSFIHRDLAARNVLVGENGVYKVADFGLARVFKGEDVYEAKNDTKLPLK 409

  Fly   956 WTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIY 1020
            ||||||::..||:.|||:|:||||::||.::|::|||.:.....:..:|.||::..|..||.::|
 Frog   410 WTAPEAIRYNRFTIKSDVWAFGILIFEIVTYGKMPYPGLTGRQALDKLENGYRIPKPFNCPHDLY 474

  Fly  1021 EMMRQAWDLNPAKRPTFAELKVKLQ 1045
            ::|.:.|:..|.:||||..|:.||:
 Frog   475 KIMLECWNAKPEERPTFETLQWKLE 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	41/115 (36%)
		PTKc_Csk_like	793..1047	CDD:270635	109/261 (42%)
frk	XP_002938349.1	SH3_Src_like	65..117	CDD:212779	6/22 (27%)
		SH2	125..220	CDD:472789	36/94 (38%)
		PTKc_Frk_like	238..505	CDD:270653	110/267 (41%)