DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and Tyk2

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001244276.1	Gene:	Tyk2 / 100361294	RGDID:	2320469	Length:	1186	Species:	Rattus norvegicus

Alignment Length:	1101	Identity:	244/1101 - (22%)
Similarity:	363/1101 - (32%)	Gaps:	300/1101 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DGVFIQSNSYLMPTPSPSGADATVSSSLERVLKPASASASPSNSNNESDNSQTSSGSQTASSASK 74
            |..:||::......|.|..|....:   ..||...:..........:......|.|:...|.:.|
  Rat   294 DPCYIQNSGQTTGDPGPELASGPAT---HEVLVTGTGGIQWRPLQTQDSERGHSRGNPQGSQSGK 355

  Fly    75 RSNRSVGRSHRGSIAQDTRRRYYFGSKDIYWCKQSREAAAAATLSGSGLTRSASSVTHKEASTHA 139
            :........|.....|:....|:...:||                        |.|..||...|
  Rat   356 KPKAPESGEHLAGSPQEPPWTYFCDFQDI------------------------SHVVLKERRVH- 395

  Fly   140 THTGGQVISRARRKPILLC-SSLSAAYAPPRRREFYFCDKYAPGPARSTPTTTTTSATSAKHESS 203
                   |.....|.:||| .|.:.|.:.....:.||             ..|..|:....||.:
  Rat   396 -------IHLQDNKCLLLCLCSQAEALSFVALVDGYF-------------RLTADSSHYLCHEVA 440

  Fly   204 PPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFLGNSRERTSKNGQQTSRSLPPIASSEEWFDE 268
            ||   ||:                |.:|                ||.. ...:.|...::.|.::
  Rat   441 PP---RLV----------------TSIQ----------------NGIH-GPLMDPFVQAKLWPED 469

  Fly   269 EAQARK--TSHEKSQKPKPKPEENHKEKEAISRK--ASGEGDLITVEIKQGL-LRKQTATTTTGQ 328
            .....:  |||            .|:....::.:  ||..|       .:|| |||...|
  Rat   470 GLYLIQWSTSH------------LHRLILTVAHRNPASRNG-------PRGLRLRKFPIT----- 510

  Fly   329 AMNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAATGSTAGDPWFLQTTGHQMPPTAPLRHNKRP 393
                    .|.|...:.|..|.|........|.......|||..|            ||.|...|
  Rat   511 --------QQPGAFVLDGWGRSFDSLGDLRQALQGCSLRAGDDCF------------PLHHCCLP 555

  Fly   394 APQ--PNAVLGAGS-SGTAPGSAVGAVLLHQQQLSQSQPHIVPPSIPPHHHHHRENNVHPIQAGA 455
            .|:  .|.|:..|| :.|.|        |:..|||             .|..|::........|.
  Rat   556 RPREISNLVIMRGSRAHTRP--------LNLSQLS-------------FHRVHQDEITQLSHLGQ 599

  Fly   456 AAALHLSSHALN----SHNLISSASNHSPKSPSQTQQQQQTTNQQQQQQQQQASHSILSTFAPAP 516
            ....::....|:    :...:.|.   .|..|.:...||...              :|....|:
  Rat   600 GTRTNVYEGLLSVGGPNEGKVDSG---CPSGPDRGSGQQLRV--------------VLKVLDPS- 646

  Fly   517 TVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLAN-CPPGGAGLMSSSLNAAQMGMHGAERAL 580
                     ...:|......|::..|....||..|.. |..|     |.::..|:...||
  Rat   647 ---------HHDIALAFYETASLMSQVSHMHLAFLHGVCVRG-----SENIIVAEFVEHG----- 692

  Fly   581 PPKSLALSGSQHGSNMLLHTAPQPPQ---ASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGV 642
             |..:.|. .|.|      ..|.|.:   |.|.|:.:......:.          ::|...|..:
  Rat   693 -PLDVWLR-RQRG------RVPMPWKMVVAQQLASALSYLEDKNL----------VHGNVCGRNI 739

  Fly   643 NASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFL 707
            ..:.......|...  ..||...:.  ||....|.::..:||        .|...|....:.|..
  Rat   740 LLARLGLEEGTNPF--IKLSDPGVG--QGALSREERVERIPW--------TAPECLSGGANSLGT 792

  Fly   708 VRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKC 772
            ..:...| |...|.:||..:..      |:.:...:.|.::....||.   |.....|.|...:|
  Rat   793 ATDMWGF-GATLLEICFDGEAP------LQGRGPSEKERFYTKKHQLP---EPSCPELATLTRQC 847

  Fly   773 -----------------LPKLGKQEF----CINSKDFVDKGWVIPEAELQLRESIGKGEFGDVML 816
                             |.:|..|..    .:||........|..:..|:....:|:|.||.|.|
  Rat   848 LSYEPAQRPSFRTILRDLTRLQPQNLVGTSTVNSDSPASDPTVFHKRYLKRIRDLGEGHFGKVSL 912

  Fly   817 GIL------RNEKVAVKMLKDEGAVQKFLA----EASVMTTLEHDNLVKFIGLVFT--SKHLYLV 869
            ...      ..|.||||.|| ||...:..:    |..::.||.|:::||:.|....  .|.:.||
  Rat   913 YCYDPNNDGTGEMVAVKALK-EGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLV 976

  Fly   870 TEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKV 934
            .||:..|||.|||   .|..:.....::||.....||.||.|:..:||||||||||:..|.:.|:
  Rat   977 MEYVPLGSLRDYL---PRHSVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKI 1038

  Fly   935 SDFGLAR-----EECYNL-DVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSF----GRV 989
            .|||||:     .|.|.: :.|..|:.|.|||.||..:|...||:||||:.|:|:.::    ...
  Rat  1039 GDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSSQSP 1103

  Fly   990 PYPRIPLADVVKH----------VEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            |...|.|..|.:.          :|.|.::..|:.||.|||.:|:..|:...:.||||..|
  Rat  1104 PTKFIELIGVTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWESEASFRPTFQNL 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	19/113 (17%)
		PTKc_Csk_like	793..1047	CDD:270635	98/280 (35%)
		STYKc	800..1044	CDD:214568	97/273 (36%)
Tyk2	NP_001244276.1	FERM_F1	33..130	CDD:408179
		FERM_F2	148..271	CDD:408177
		Jak1_Phl	290..433	CDD:407742	33/186 (18%)
		SH2	438..536	CDD:417686	30/165 (18%)
		PKc_like	591..866	CDD:419665	56/351 (16%)
		PTKc_Tyk2_rpt2	891..1173	CDD:270664	97/278 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810