DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and abl1

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_005172104.1	Gene:	abl1 / 100000720	ZFINID:	ZDB-GENE-100812-9	Length:	1081	Species:	Danio rerio

Alignment Length:	479	Identity:	175/479 - (36%)
Similarity:	263/479 - (54%)	Gaps:	39/479 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 GSQHGSNMLLHTAP---QPPQASQPAA------VVGVSGSGSAGMSTSLHSFDING-----VTAG 639
            |:.|.:...:|.:.   .||..|:.|.      ::.........:..:|:.|..:|     :|.|
Zfish    35 GAPHCNVFTVHESRPDFDPPGLSEAARWNSKENLLSGPSENDPNLFVALYDFVASGDNTLSITKG 99

  Fly   640 S-----GVNASSAWSSGSTTAMNHASLSPT-ALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLL 698
            .     |.|.:..|....|  .|.....|: .:.|..       .|....|:||.::|:.||:||
Zfish   100 EKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYITPVN-------SLEKHSWYHGPVSRNAAEYLL 155

  Fly   699 QPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYL-ENKLTIDDEEYFENLGQLVAHYEADA 762
            ....:|.||||||.:.||..::.:.::.:|.|||:... :.||.:..|..|..|.:||.|:...:
Zfish   156 SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVS 220

  Fly   763 DGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEK--VA 825
            |||.|.|....||..|......|.:: || |.:...::.::..:|.|::|:|..|:.:...  ||
Zfish   221 DGLITTLHYPAPKRNKPTIYGVSPNY-DK-WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVA 283

  Fly   826 VKMLK-DEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQH 889
            ||.|| |...|::||.||:||..::|.|||:.:|:.......|::||:|:.|:|:||||...||.
Zfish   284 VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTHGNLLDYLRECNRQE 348

  Fly   890 ITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG- 950
            :.....:..|...:|.|||||.|..:||||||||.|:.|:.:.||:||||:|   .:.|....|
Zfish   349 VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENNLVKVADFGLSRLMTGDTYTAHAGA 413

  Fly   951 KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGC 1015
            |.||||||||:|...:||.|||:|:||:|||||.::|..|||.|.|:.|.:.:|..|:|:.||||
Zfish   414 KFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMDRPEGC 478

  Fly  1016 PPEIYEMMRQAWDLNPAKRPTFAE 1039
            |.::||:||..|..|||:||:|||
Zfish   479 PEKVYELMRACWRWNPAERPSFAE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	36/97 (37%)
		PTKc_Csk_like	793..1047	CDD:270635	115/254 (45%)
		STYKc	800..1044	CDD:214568	114/247 (46%)
abl1	XP_005172104.1	SH3_Abl	79..132	CDD:212784	11/54 (20%)
		SH2_ABL	137..230	CDD:198189	34/92 (37%)
		PTKc_Abl	249..511	CDD:270645	115/254 (45%)
		Pkinase_Tyr	256..507	CDD:285015	114/247 (46%)
		FABD	958..1081	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910