Protein Alignment CG14712 and nup153

DIOPT Version :10

• Sequence 1: NP_650096.1
• Gene: CG14712 / 41397
• FlyBaseID: FBgn0037924
• Length: 1266
• Species: Drosophila melanogaster
• Sequence 2: NP_001313313.1
• Gene: nup153 / 571621
• ZFINID: ZDB-GENE-030131-4581
• Length: 1436
• Species: Danio rerio
• Alignment Length: 1530
• Identity: 362/1530 - (23%)
• Similarity: 528/1530 - (34%)
• Gaps: 475/1530 - (31%)

  Fly    40 PKGSNTS--LNGTRTPERSLMNRSATSS-------STITRQKLNLSQVDPRTFADVHSSGLSSRI 95
            |.||:.:  .:|..:||.|..|...::|       ..::|..||.:.:.   |..:..|
Zfish    74 PNGSDEAPLRDGRDSPEPSTSNTEPSTSRASLNFQEALSRPPLNRTHLQ---FPSLDGS------ 129

  Fly    96 VALSERSGLQRSMSASNLYNPLTQPRRAPASPLPYKSRAPTLSITQIAPPERSFYSGNTLSSLLR 160
            .||...|.|....|.|.          ||.|..|: :.....|:.:......|.:..:.:|
Zfish   130 PALGGSSSLFSQPSTST----------APFSGSPF-AVTSNFSLVKEIKDSSSQHEDDNIS---- 179

  Fly   161 SNSLVGLVPKTTEQEQLSRENRPILHPPHPQHESEPTRSVLEELKEISRKRINTEDTQQAQDYTK 225
              :..|...:.::::..:.:..|:|..|    |:|.|.|..:
Zfish   180 --TTSGFSSRASDKDVPTSKTVPLLWSP----ETERTHSGSQ----------------------- 215

  Fly   226 RSCQQNVDFVDFVAHHRQQQKLRNL-------QQQQNQSFKRQRELTVSVPLRHHSTSLSAASPA 283
                        .||...::...||       ....|.|.....:|..| |.....|:...|| |
Zfish   216 ------------TAHSGLKKPAFNLSVFGTSSSSVLNSSVLNSSQLGDS-PFYPGKTTYGGAS-A 266

  Fly   284 LQHMNSNGTISPTQSP--EQVAKRPNCSYSNDITSSLSSSCRHSNKRKLLDMRERFQHSKNDT-- 344
            ::...|. ..:|.|.|  .|:..:|..:....:||:.:        |::|...||......|.
Zfish   267 MRTARSR-PATPYQPPVRRQIKAKPTGAQPCGVTSATA--------RRILQSLERMSSPLADAKR 322

  Fly   345 LASGGSSPENSPENVAKI-------QRKVDAEAVSKAMSMPVVTVAAVPASRAIS-----AP-AI 396
            :.|..|||.::..|...:       :||....:|.....:.|...|||..:|:||     .| .:
Zfish   323 IPSTVSSPLSASLNHTDLDISNYQAKRKRLEPSVPPVQKLVVPAAAAVSGNRSISFRPSLTPGGV 387

  Fly   397 QKAVPQVT-EKPKLTLFNARQSQTI---AEQPRPD---LSSP--EVDAGEYAGIQFVKPKQQNSM 452
            .:.|.:.: |.|      .|||..|   |:.|.|.   ||.|  ...|...|.:...|.|::.::
Zfish   388 SRGVEKTSRETP------VRQSPPISEPAQAPPPSTSTLSYPLSSTPAANSAALGGGKMKRERAI 446

  Fly   453 LAAKNPSVERTHKTKLAIMLSGLKGELYLGEPD-----ELDAPAPKSAPAPVTLPTPVKPIIIAP 512
                .||.:|                     ||     |.|.| |.|.|:..||||
Zfish   447 ----RPSSKR---------------------PDDEVAEEPDLP-PASLPSNFTLPT--------- 476

  Fly   513 VTTSTTTVTSTATIST--------------------SAPSKPIILSNQVIK------PADVPNTN 551
            .|.||...||:...||                    :.||.|...|:.::|      |:..|::.
Zfish   477 FTFSTPPPTSSLKSSTAPLITVSEEPAANKQPAAPSTPPSAPFTFSSPIVKATAASPPSFSPSSG 541

  Fly   552 STGSVPKLVLGQ--------------------------PAPPAKT-EQTPPKPIDKVPAAQADIP 589
            .|.|.|.:.:|.                          |..|||. :|.....|.|.|...:
Zfish   542 FTFSAPTMKMGPSFSNGKIVPSVAPVKSVVIEEKEFEGPFKPAKVLKQGSVLDILKGPGFAS--- 603

  Fly   590 PKFELSTKPV--TPATSSQPLISFGTPKSTAAPSFSFGSA--TNTTS-----STIANITNTTTSK 645
            |....:.||:  |..|:|.|...||......|.|::.|:.  .|..|     :.:|...||.:||
Zfish   604 PSQNSTDKPLQSTSTTTSSPFSGFGDKFRPPAGSWNCGTCMLQNKPSDKKCVACLAPQPNTDSSK 668

  Fly   646 PIFSFGQTPAN-----GPTVGG------LSGFKTEAPATTSVSTTNPGTQVTSTTTF-------- 691
            ......:.||:     .|..|.      |...|.:|....:..|..|||.|.|:.|.
Zfish   669 SDSKPAEAPASISSLFAPPAGSWECDTCLVSNKPDAVKCVACDTAKPGTGVKSSLTLLAASESSS 733

  Fly   692 GVTPPKTTTTVAPTTTVSLNFGQPM--PSFGAADTGVKPMFSFGKSNNLSSGTPTTNGSDAAAA- 753
            ..|...|||..|.|:|..|..|...  |. ||.|..|  .....|:.:|......|....||||
Zfish   734 STTTTATTTAAALTSTGLLGLGDKFKKPE-GAWDCDV--CMVQNKAQDLKCVACLTAKPGAAAAP 795

  Fly   754 --KPAVFSFGGSTTQPAAAAPTPVFG-SLSKPLGE--------------------GFASPGANKS 795
              .||       :...::|||...|| ...||.|.                    ..|.|||...
Zfish   796 LSTPA-------SAPVSSAAPLLGFGDKFKKPEGSWECDVCCVQNKADDQQCVACQSAKPGAKIE 853

  Fly   796 ETTKPSIFGNLDN-----------GLGNAMKSSTNV----------AATTAAELPKPFGFAATTT 839
            .....|.||...|           |.|:...||::.          ::||..   ..|||..::|
Zfish   854 SKGFSSSFGVQSNSTDSNTSGFKFGTGSTDSSSSSAGLKFGGTFSDSSTTGG---IKFGFGLSST 915

  Fly   840 AAGGGSTATNLFSFGGTATSKAAEPAPASQKNLFGLNATTTTPFAFGGAAAGAADKSENKDNKPI 904
            ::.|       |.|||:::........::.........::|..|||||:|....:|.........
Zfish   916 SSEG-------FKFGGSSSDAGGAKLSSTLSESTATKESSTKSFAFGGSADDTLEKKSKTQESNT 973

  Fly   905 AFAFGAGNNSAVANPSGVFSFGG--------------------TDKSAP---PAFGSGTTSVTSA 946
            .|.||.|:..|..:.:..|.||.                    .:|.||   |...:.||:.|:|
Zfish   974 GFKFGGGSGMASGSENSSFLFGAKPSEKGSSNPSFSFPVPQSKVEKDAPSETPPVSNTTTTTTAA 1038

  Fly   947 TATPTNNTFGFSTTQKPATPMFGSGSTQQSSTPAVAATKPFTLGGGAPTTPSASPASGGFSFSAV 1011
            .|.|   .||.|...:.:.|.||..:|::.:    ..|..||.|.......:::|:|   :|...
Zfish  1039 NALP---VFGKSLVAESSAPKFGEPATKEQT----LVTSTFTFGKPEEKKDTSAPSS---TFLFG 1093

  Fly  1012 ATKNTTAPTAGTNL-----------------FGSPASAS---KPSFNFGGNTATQAAAAGSPAGG 1056
            ::|....||.....                 ||.||.::   ||||.| |.:.|:.:|. .|:.|
Zfish  1094 SSKEAEKPTPNLGFAFSEPDPPKDFPKPALTFGKPAESTEPPKPSFGF-GQSLTETSAP-KPSFG 1156

  Fly  1057 F--SFATTTKKEDSASTNMFGSPNTGVVKP----------------------------------- 1084
            |  :..::|....|::.::||:|.|..:.|
Zfish  1157 FMANSTSSTPASSSSTPSLFGTPTTSSLAPTPAPTSTFVFGQNSSSELNVGKTFVFGQQQQDSQP 1221

  Fly  1085 --------------NFSFSSNNPTPAPTFGGFGA--PAAAAPTATSTNQSKPFAFGASTP----- 1128
                          .|...||:.||:.|||...:  ||:||| |.|.|.| ||.|.::.|
Zfish  1222 APPAAPSAAPAQPFQFGSGSNSSTPSFTFGAAASSTPASAAP-APSANPS-PFVFSSAAPSSGFG 1284

  Fly  1129 ----------AAAPQPPLGG----NLFANAVSATQNQTKPSGVFSFGA---AKSTAGTTA---GN 1173
                      |:.|..|..|    :..|:|..|:....|||....||.   |..|.|:||   |.
Zfish  1285 SGQTPIFGQSASQPSAPAFGSAAPSFSASATPASTFGAKPSSAPVFGQQANAAPTFGSTAASTGQ 1349

  Fly  1174 APFSFGGASAGGI-ASPPSNQGLNTAKPFSFGGAGGTPAPNVFGSPAPAPPASNPTGGFNFGGVS 1237
            ..|.||  |.||. ||..||      ..|:|||....||      .:||.||.||..|..| |.|
Zfish  1350 GGFQFG--STGGFGASATSN------SVFNFGGGSAAPA------ASPAMPALNPPAGGGF-GFS 1399

  Fly  1238 PAQQANAG---NMFAPTP------ESRPIRKATRR 1263
            |....|.|   :.|..:|      ..|.|:.|.||
Zfish  1400 PTPAFNIGSAKSSFTASPAGQNSIAGRKIKTAVRR 1434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14712	NP_650096.1	Nucleoporin_FG2	968..>1180	CDD:435043	76/309 (25%)
nup153	NP_001313313.1	Nup153	98..605	CDD:462533	127/626 (20%)
		ZnF_RBZ	636..660	CDD:197784	4/23 (17%)
		RanBP2-type Zn finger	638..657	CDD:275375	3/18 (17%)
		zf-RanBP	687..716	CDD:395516	5/28 (18%)
		RanBP2-type Zn finger	691..710	CDD:275375	3/18 (17%)
		zf-RanBP	761..790	CDD:395516	8/31 (26%)
		RanBP2-type Zn finger	765..784	CDD:275375	4/20 (20%)
		zf-RanBP	820..849	CDD:395516	3/28 (11%)
		RanBP2-type Zn finger	824..843	CDD:275375	0/18 (0%)