DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14712 and Nup214

DIOPT Version :9

Sequence 1:	NP_650096.1	Gene:	CG14712 / 41397	FlyBaseID:	FBgn0037924	Length:	1266	Species:	Drosophila melanogaster
Sequence 2:	NP_652039.2	Gene:	Nup214 / 46091	FlyBaseID:	FBgn0010660	Length:	1711	Species:	Drosophila melanogaster

Alignment Length:	1363	Identity:	343/1363 - (25%)
Similarity:	519/1363 - (38%)	Gaps:	386/1363 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RTPERSLMNRSATSSSTITRQKLNLSQVDPRTFADVHSSGLSSRIVALSERSGLQRSMSASNLYN 115
            :.|...|...:|.:||.::......:...|.|    ...|..::  |.:...|...|.|.:|.:.
  Fly   478 KAPAPQLSFGTAPTSSPVSFGAPTTNAAKPTT----PFGGFGTQ--ATTTAMGSMFSASGANAFG 536

  Fly   116 PLTQPRRAPASPLPYKSRAP--TLSITQIAPPERSFYSGNTLSSLLRSNSLVGLVPKTTEQEQLS 178
            .:...:.|.||..| ::.||  |:..|..:.|     :...|.::..:.:.|...|.|:...|::
  Fly   537 GMALNKPAIASVTP-RTAAPGSTVPATPASAP-----ANKPLYTVPLTFTPVDTKPATSAPPQIA 595

  Fly   179 RENRPILHPPHPQHESEPTRSVLEELKEISRKRIN--TEDTQQAQDYTKRSCQQNVDFVDFVAH- 240
            .|:   |.|    .::||.      :|::...:|.  ::|.|:.::.||       :.:..:|.
  Fly   596 DES---LKP----DDTEPI------IKDMIALQIEAFSKDIQKQKEQTK-------ELLKGIAAP 640

  Fly   241 ---HRQQQKLRNLQQQQNQSFKRQRELTVSVPLRHHSTSLSAASPALQHMN-SNGTISPTQSPEQ 301
               ....::|.:||:...|:...:.||.|. .||             |.:| :...::..:...:
  Fly   641 SALRAYAKRLDDLQELNEQAKDVEFELDVQ-GLR-------------QGLNEAYAIVAECRGKLE 691

  Fly   302 VAKRPNCSYSNDITSSL-SSSCRHSNKRKL--------------------LDMR-ERFQHSKNDT 344
            :.::|      :||..: ||||..|.:|.|                    :|:: |:||    |.
  Fly   692 IYRKP------EITRLMNSSSCDPSGRRMLARLQSYVAANEAQLRLAQQHVDLQWEQFQ----DV 746

  Fly   345 LASGGSSPENSP------------ENVAKIQRKVDAEAVSKAMSMPVVTVAAVPASRAISAPAIQ 397
            :.....|..:.|            :|:...||.|.....||.....::..|.:...:  |.....
  Fly   747 VRRNSKSRMHMPCLEGIYQRLTRLQNLTSNQRIVQNNIKSKLKERGLLQAALLDQEK--SRTRTN 809

  Fly   398 KAVPQVTEK--------------PKLTLFNARQSQTIAEQPRPDLSSPEVDAGEYAGIQF----- 443
            :||..:|:.              .|||....::.:.|.:..:.::..|:  ..:..|::.
  Fly   810 EAVDTLTDSILTMSLSQVVDSNAAKLTRERLQKIRNIVQLQKINVICPQ--RPDRVGLKSEVILE 872

  Fly   444 VKPKQQNSMLAAKNPSVERTHKTKLAIMLSGLKGELYLGEPDELD-APAPKSAPAP---VTLPTP 504
            .|.:.:....||..|:....: |:.|:           ..|...| ||.|..||.|   ||:..|
  Fly   873 TKRRAEQIKRAAAKPATANKY-TQAAV-----------APPSPPDVAPTPAVAPMPQATVTVAPP 925

  Fly   505 V-KPIIIAP-------VTTSTTTVTST----------ATISTSAPSKPIILSNQVIKP------- 544
            : ||:...|       |.|..||..:|          ...||..|:...:...:..||
  Fly   926 LPKPMPSIPSVVEKPGVPTHPTTPVATPFSFSQSIPFVKTSTVTPTTNTVTPGEAAKPGLSIFGG 990

  Fly   545 ADVPNTNSTGSVPKLVL----GQPAPPAKTEQTPPKPIDKVPAAQADIP----PKFELST----- 596
            :.:.:.:..|...|..|    |.||..|.|    ||| :.:.|.:...|    ||.:.:.
  Fly   991 STISSFSFGGGAAKSALSFGTGSPAVAAPT----PKP-NPLSAVEKPTPEPTKPKEQKAAESKEF 1050

  Fly   597 KPVTPATSSQPLISFGTPKS-TAAPSFSFGSATNTTSSTIANITNTTTSKPIFSFGQTPAN---G 657
            |.|.|.|....:..  .||: |...||.||..|. |..|:.|    |:|.| ||||...::   |
  Fly  1051 KAVQPETEESKVPQ--KPKAETENKSFGFGGFTG-TGGTVGN----TSSSP-FSFGGLGSSLGFG 1107

  Fly   658 PTVGGLSGFKTEAPATTSVSTTNPGTQVTSTTTFGV----------TPPKTTTTVAPTTTVSLNF 712
            .|...:...:..:.|||||:|:      .||..||:          :.|.||.|...||..|
  Fly  1108 GTAAAVPKSEPSSTATTSVATS------ASTAPFGIFSAALAKPSNSEPITTVTSNTTTITS--- 1163

  Fly   713 GQPMPSFGAADTGVKPMFSFGKSNNLSSGTPTTNG-----------SDAAAAKPA---------- 756
               .|:...|.:.|....|...:|.::|.|....|           :.|...|||
  Fly  1164 ---KPTNVIASSSVTDAPSVTTTNAVTSSTDPIGGLFSSVTICKPNTPADTTKPANIFGGGLSAG 1225

  Fly   757 VFSFGGS---------TTQPAAAAPTPVFGSLSKPLGEGFASPGANKSE--TTKPSIFGNLDNGL 810
            .|||||:         :|:|.|.|||.|             :...||::  :|.||..
  Fly  1226 SFSFGGTIDASKGLFGSTKPVATAPTSV-------------TEANNKTDPISTTPSAI------- 1270

  Fly   811 GNAMKSSTNVAATTAAELPKPFGFAATTTAAGGGSTATNLFSFGGTATSKAAEPAPA-SQKNLFG 874
                  ||..|.||.:   .|....|..|||...:::|       |.||..|.|..| |..|.|
  Fly  1271 ------STTTATTTVS---SPAVVPAAVTAAVPATSST-------TVTSSTAVPGSAFSFSNAF- 1318

  Fly   875 LNATTTTPFAFGGAAAGAADKSENKDNKPIA----FAFGAGNNSAVANPSGVFSFG---GTDKSA 932
                  :..:.|||||.....|     .|:|    .|...||||:    :.||..|   .|..:|
  Fly  1319 ------STLSAGGAAAPTTSAS-----APLAAKSPTATSTGNNSS----NSVFGGGFAVATSTAA 1368

  Fly   933 PPAFGSGTTSVTSATATPTNNTFGFSTTQKPATPMFGSGSTQQSSTPAVAATKPFTLGGGAPTTP 997
            |.|     :...||..:|.::...|.:..|..|.:||..:|..|:|.|.|             ||
  Fly  1369 PVA-----SPFQSAAKSPVSSANIFGSIPKAETSVFGGATTAPSNTTAAA-------------TP 1415

  Fly   998 SASPASGGFSFSAVA------TKNTTAPTAGTNLFGSPASASKPSFNFGGNTATQAAAAGSPAGG 1056
            .|.|| |.|:.:|::      :..|.||.:|.|:||   .|.|||. ||     |.|.||. :||
  Fly  1416 DAPPA-GLFASAAISNPSPFGSPTTRAPASGGNIFG---QAVKPSV-FG-----QPAQAGD-SGG 1469

  Fly  1057 FSFATTTKKEDSASTNMFGSPNTGVVKPNFSFSSNNPTPAPTFGGFGAPAAAAPTATSTNQSKPF 1121
            ..|...:......|:::||..||.                   |..|||||.   :||....|
  Fly  1470 SIFGGGSASTPFGSSSIFGGGNTQ-------------------GAVGAPAAG---STSIFGQK-- 1510

  Fly  1122 AFGASTPAAAPQPPLGGNLFANAVSATQNQTKPSGVFSFGAAKSTAGTTAGNAPFSFGGASAGGI 1186
            .||.|:.||   |..|||:|:|.|.:.|......|..|...:.:||...:|.:.|. ||:|:||.
  Fly  1511 VFGQSSAAA---PAAGGNIFSNPVGSPQASPFGGGGNSIFGSPATAPPASGGSIFG-GGSSSGGF 1571

  Fly  1187 AS----PPSNQGLNTAKPFSFG-GAGGTPAPNVFGSP-APAPPASNPTGGFN----FGGVSPA 1239
            .|    .|:..|...    .|| |.||:.|...|||| ||....:.| |||.    ||| |||
  Fly  1572 GSFTQTTPAQGGFGG----GFGQGGGGSVAQTGFGSPQAPQQQTTTP-GGFGAKPVFGG-SPA 1628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14712	NP_650096.1	Nucleoporin_FG2	954..>1180	CDD:292589	71/231 (31%)
Nup214	NP_652039.2	WD40	<31..>233	CDD:225201
		WD40 repeat	38..86	CDD:293791
		WD40 repeat	90..131	CDD:293791
		WD40 repeat	139..173	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23193
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100