DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14712 and Nup153

DIOPT Version :9

Sequence 1:	NP_650096.1	Gene:	CG14712 / 41397	FlyBaseID:	FBgn0037924	Length:	1266	Species:	Drosophila melanogaster
Sequence 2:	NP_001093940.1	Gene:	Nup153 / 25281	RGDID:	3216	Length:	1468	Species:	Rattus norvegicus

Alignment Length:	1481	Identity:	332/1481 - (22%)
Similarity:	527/1481 - (35%)	Gaps:	469/1481 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FNMSSMSPMADSTRIDASLLNNRPAASNFLRGLSPKGSNTSLNGTRTPERSLMNRSATSSSTITR 70
            ||:|:...::.|....:.|..::...|.|..|      .|:..|.....|....||....:.:.|
  Rat   232 FNLSAFGTLSTSLGNSSILKTSQLGDSPFYPG------KTTYGGAAAAVRQNKVRSTPYQAPVRR 290

  Fly    71 QKLNLSQVDPRTFADVHSSGLSSRIVALSERSGLQRSMSASNLYNPLTQPRRAPA-------SPL 128
            | :...|::.:::.  .:|..:.||:           .|...:.:||...:|.|:       |||
  Rat   291 Q-MKAKQLNAQSYG--VTSSTARRIL-----------QSLEKMSSPLADAKRIPSAVSSPLNSPL 341

  Fly   129 PYKS------RAPTLSITQIAPPERSFYSGNTLSSLLRSNSLVGLVPKTTEQEQLSRENRPILHP 187
            ....      :|....:....||.:...:...:|  :.:|..|...|..|....|.:.|:.|
  Rat   342 DRSGIDSTVFQAKKEKVDSQYPPVQRLMTPKPVS--IATNRTVYFKPSLTPSGDLRKTNQRI--- 401

  Fly   188 PHPQHESEPTRSVLEELKEISRKRINTEDTQQAQDYT----------------KRSCQQNVDFVD 236
                   :...|.::| |.|||:....|......:::                |...::...||.
  Rat   402 -------DKKNSTVDE-KNISRQNREQESGFSYPNFSIPAANGLSSGVGGGGGKMRRERTTHFVA 458

  Fly   237 FVAHHRQQQKLRNLQQQQNQSFKRQRELTVSVPLRHHS-TSLSAASPALQHMNSNGTISPTQSPE 300
            ......::.::..|.|             :|:|:...| .:.:.:|||:...:|: ::||:|...
  Rat   459 SKPSEEEEVEVPLLPQ-------------ISLPISSSSLPTFNFSSPAISAASSS-SVSPSQPLS 509

  Fly   301 QVAK--------RPNCSYSNDITSSLSS---------------------SCRHSNKRKLLDMRER 336
            ...:        .|..::|:.|..|..:                     |..:|:...:|.....
  Rat   510 NKVQMTSLGSTGNPVFTFSSPIVKSTQADVLPPASIGFTFSVPLAKTELSGPNSSSETVLSSSVT 574

  Fly   337 FQHSK--NDTLASGGSSPENSPENVAKIQRKVDAEAVSKAMSMPVVTVAAVPA--SRAISAPAIQ 397
            .|.:.  |.:.:...|:|...|...|||.|:..           |:.:...|.  |..:.:||:|
  Rat   575 AQDNTVVNSSSSKKRSAPCEDPFTPAKILREGS-----------VLDILKTPGFMSPKVDSPALQ 628

  Fly   398 KAVPQ--VTEKPKLTLFNARQSQTIAEQPRPDLSSPEVDAGE--YAGIQF----------VKPKQ 448
            .....  |..:|.::.|                ||..|:.||  .||..:          |...:
  Rat   629 PTTTSSIVYTRPAISTF----------------SSSGVEFGESLKAGSSWQCDTCLLQNKVTDNK 677

  Fly   449 QNSMLAAKNPSVERTHKTKLAIMLSGLKGELYLGEPDELDAPAPKS------------------- 494
            ..:..|||.|..|...:|.             :|.|.:.|.||..|
  Rat   678 CIACQAAKLPLKETAKQTG-------------IGTPSKSDKPASTSGTGFGDKFKPAIGTWDCDT 729

  Fly   495 ----------------APAPVTLPTPVKPIIIA---PVTTSTTTVTSTATISTSAPSK------- 533
                            .|.|.|......|:.:|   |||.|::|..:|.|:......|
  Rat   730 CLVQNKPEAVKCVACETPKPGTGVKRALPLTVASESPVTASSSTTVTTGTLGFGDKFKRPVGSWE 794

  Fly   534 -PI-ILSNQVIKPADVPNTNSTGSVPKLVLGQPAPPAKTEQTPPKPID------------KVPAA 584
             |: .:||   |..|....:.|...|.||        ....:.|.|:.            |.|..
  Rat   795 CPVCCVSN---KAEDSRCVSCTSEKPGLV--------SASSSNPVPVSLPSGGCLGLDKFKKPEG 848

  Fly   585 QAD-----IPPKFELSTKPVT-----PATSSQPLISFGTPKS-TAAPS-FSFGSATNTTSSTIAN 637
            ..|     :..|.: |||.:.     |.|.|: ...|||..| ..||| |.||     ..|:.:.
  Rat   849 SWDCEVCLVQNKAD-STKCIACESAKPGTKSE-FKGFGTSSSLNPAPSAFKFG-----IPSSSSG 906

  Fly   638 ITNTTTSKPIFSFGQTPANGPTVGGLSGFKTEAPATTSVSTTNPGTQVTSTTTFGVTPPKTTTTV 702
            ::.|.||...|.||..          .|||.             ||...|
  Rat   907 LSQTFTSTGNFKFGDQ----------GGFKL-------------GTSSDS--------------- 933

  Fly   703 APTTTVSLNFGQPMPS----FGA-ADTGVKPMFSFGKSNNLSSGTPTTNGSDAAAAKPAVFSFGG 762
            ..|.|::.||..|.|:    ||. .|:..:.:.:..|::|...| |::..|:.|::.|  |.||.
  Rat   934 GSTNTMNTNFKFPKPTGDFKFGVLPDSKPEEIKNDSKNDNFQFG-PSSGLSNPASSAP--FQFGV 995

  Fly   763 STT-QPAAAAPTPVFGSLSKPLGEGFASPGANKSETTKPS------IFGNLDNGLGNAMKSSTNV 820
            ||. |.......|...|.....|.|.|:|.:...:||..|      .||.:|         :.:|
  Rat   996 STLGQQEKKEELPQSSSAGFSFGAGVANPSSAAIDTTVTSENKSGFNFGTID---------TKSV 1051

  Fly   821 AATTAAELPKPFGFAATTTAAGGGSTATNLFSFGGTATSKAAEPAPASQKNLFGLNAT------- 878
            :.|       ||.:..|.......|.....|:||      ..:.|..|..::|.|..|
  Rat  1052 SVT-------PFTYKTTEAKKEDASATKGGFTFG------KVDSAALSSPSMFVLGRTEEKQQEP 1103

  Fly   879 -TTTPFAFGGAAAGAADKSENKDNK--PIAFAFGAGNNS------------AVANPS-------- 920
             |:|...||       .|::|::.|  |: |:||....:            :||.||
  Rat  1104 VTSTSLVFG-------KKADNEEPKCQPV-FSFGNSEQTKDESSSKPTFSFSVAKPSVKESDQLA 1160

  Fly   921 -GVFSFGG-----TDK-SAPPAFGSGTTSVTSATATPTNNTFGFSTTQKPATPMFGSGSTQQSST 978
             ..|:||.     ||: :|.||| |...|.:|:::||..::         :..:|||.::  ||:
  Rat  1161 KATFAFGNQTNTTTDQGAAKPAF-SFLNSSSSSSSTPATSS---------SASIFGSSTS--SSS 1213

  Fly   979 PAVAATKPFTLGGGAPTTPSASPASGGFSFSAVATKNTTAPTAGTNLF---GSPASASK-----P 1035
            |.|||   |..|      .:::|.|.. :|...|..:|:.|.    ||   |.||:.|.     |
  Rat  1214 PPVAA---FVFG------QASNPVSSS-AFGNSAESSTSQPL----LFPQDGKPATTSSTASAAP 1264

  Fly  1036 SFNFGGNTATQAAAAGSPAGGFSFATTTKKEDSASTNMFGSPNTGVVKPNFSFSSNNPTPAPTFG 1100
            .|.||    |.|::..:.:.||:|..||....|.|..:||:.::.            |:.:|.||
  Rat  1265 PFVFG----TGASSNSTVSSGFTFGATTTSSSSGSFFVFGTGHSA------------PSASPAFG 1313

  Fly  1101 GFGAPAAAAPTATSTNQSKPFAFGASTPAAAPQPPLGGNLFAN-AVSATQNQTKPSGVFSFGAAK 1164
                 |...||           ||.|..|:.|.||..|::.:: |:.:..:|..|..  :||...
  Rat  1314 -----ANQTPT-----------FGQSQGASQPNPPSFGSISSSTALFSAGSQPVPPP--TFGTVS 1360

  Fly  1165 STA-----GTTAGNAPFSFGGASAGGI---ASPPSNQGLNTAKP---FSFGGAGGTPAPNVFGSP 1218
            |::     |.....:.|..|.|:|..:   .|..:|.......|   |:||.:..|||
  Rat  1361 SSSQPPVFGQQPSQSAFGSGTANASSVFQFGSSTTNFNFTNNNPSGVFTFGASPSTPA------- 1418

  Fly  1219 APAPPASNPTGGFNFGGVSPAQ---QANAGNMFAPTPES---RPIRKATRR 1263
            |.|.|:.  :|||:| ..|||.   .:|..|||:.:..|   |.|:.|.||
  Rat  1419 AAAQPSG--SGGFSF-SQSPASFTVGSNGKNMFSSSGTSVSGRKIKTAVRR 1466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14712	NP_650096.1	Nucleoporin_FG2	954..>1180	CDD:292589	61/239 (26%)
Nup153	NP_001093940.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..128
		Nup153	114..629	CDD:285770	81/454 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..222
		29 X 2 AA repeats of F-G. /evidence=ECO:0000305	237..1411		304/1409 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..429		11/52 (21%)
		zf-RanBP	661..687	CDD:279035	4/25 (16%)
		RanBP2-type Zn finger	662..681	CDD:275375	1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..714		7/33 (21%)
		zf-RanBP	722..750	CDD:279035	1/27 (4%)
		RanBP2-type Zn finger	725..744	CDD:275375	0/18 (0%)
		zf-RanBP	789..818	CDD:279035	6/31 (19%)
		RanBP2-type Zn finger	793..812	CDD:275375	5/21 (24%)
		zf-RanBP	846..875	CDD:279035	6/29 (21%)
		RanBP2-type Zn finger	850..869	CDD:275375	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..985		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1145		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1209		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1231..1260		10/33 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1308..1380		22/89 (25%)
		Nup_retrotrp_bd	1378..1468	CDD:287557	32/99 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1414..1468		23/63 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23193
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	2.060