DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14712 and Pom121

DIOPT Version :9

Sequence 1:	NP_650096.1	Gene:	CG14712 / 41397	FlyBaseID:	FBgn0037924	Length:	1266	Species:	Drosophila melanogaster
Sequence 2:	NP_683734.2	Gene:	Pom121 / 107939	MGIID:	2137624	Length:	1200	Species:	Mus musculus

Alignment Length:	1380	Identity:	347/1380 - (25%)
Similarity:	496/1380 - (35%)	Gaps:	391/1380 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PMADSTRIDASLLNNRPAASNFLRGLSPKGSNTSLNGTRTPERSLMNRSATSSSTITRQKLN--- 74
            |.|.|:.:..:..:.|||.:     .||..:.:.:||:....||.:.....:...:....|.
Mouse    78 PRALSSFVRDARRHPRPALT-----ASPPPAKSPVNGSLCEPRSPLGGPDPAELLLMGSYLGKPG 137

  Fly    75 -----LSQVDPRTFADVHSSGLSSRIVALSERSGLQ---RSMSASN-----------LYNPLTQP 120
                 |.| |||                  ||.|.:   ||...::           |..||.:|
Mouse   138 PPEPALRQ-DPR------------------ERPGRRPPARSPPPASAVQRVHHVYPALPTPLLRP 183

  Fly   121 RRAPASPLPYKSRAPTLSITQIAPPERSFYSGNTLSSLLRSNSLVGLVPKTTEQEQLSRENRPIL 185
            .|.|    |::...| ||...:..|.|.:.......|||      |.:|.....   ....:.:|
Mouse   184 SRRP----PHRDCGP-LSSRFVITPRRRYPIQQAQYSLL------GALPTVCWN---GGHKKAVL 234

  Fly   186 HPPHPQHESEPTRSVLEELKEISRKRINTEDTQQAQDYTKRSCQQNVD---FVDFVAHHRQQQKL 247
            .|.:.:....|   |...:.....|...:..::|..|.|..|...|..   ..:.|.:..:::|.
Mouse   235 SPRNSRMVCSP---VTVRIAPPDSKLFRSSMSEQILDTTLSSPSSNAPDPCAKETVLNALKEKKK 296

  Fly   248 RNLQQQ-----QNQSFKRQRELTVSVPLRHHSTSLSAASPALQHMNSNGTISPTQSPEQVAKRPN 307
            |.:.::     ..|..||:|          |.:..|..| |.:.:.:||.      |.....:|.
Mouse   297 RTVAEEDQLHLDGQENKRRR----------HDSGGSGHS-AFEPLVANGV------PAAFVPKPG 344

  Fly   308 CSYSNDITSSLSSSCRHSNKRKLLDMRERFQHSKNDTLASG--GSSPENSPENVAKIQRKVDAEA 370
             |....:.|  .||..|.|||.        :.|...:|||.  |..|.:|        |.....:
Mouse   345 -SLKRSLAS--QSSDDHLNKRS--------RTSSVSSLASACTGGIPSSS--------RNAITSS 390

  Fly   371 VSKAMSMPVVTVAAVPASRAISAPAIQKAVPQVTEKPKLTLFNARQSQTIAEQPRPDLSS--PEV 433
            .|....:..:...:.|.|...|:||..::  |..|:|        ..:|..|:|....||  |.|
Mouse   391 YSSTRGISQLWKRSGPTSSPFSSPASSRS--QTPERP--------AKKTREEEPCQQSSSSPPLV 445

  Fly   434 DAGEYAGIQFVKP---KQQNSMLAAKNPSVERTHKTKLAIMLSGLKGELYLGEPDEL-------- 487
            ...|..|.:....   |||:|..:...|......|.|:.::.|....:|.|..|.||
Mouse   446 TDKESPGEKVTDTTTGKQQSSWTSPPTPGSSGQRKRKIQLLPSRRGDQLTLPPPPELGYSITAED 510

  Fly   488 -----------------DAPAPKSAPAPVTLPTPVKPIIIAPVTTSTTTVTSTATISTSAPSKPI 535
                             |.|...||.|....|:...|.              |.|:....|:
Mouse   511 LDMERKASLQWFNKVLEDKPDDASASATDGPPSTSPPF--------------TFTLPAVGPA--- 558

  Fly   536 ILSNQVIKPADVPNTNSTGSVPKLVLGQPAPPAKTEQTPPKPIDKVPAAQADI----PPKFELST 596
                  ..||.:|..:|...:..|         |..|..|.|....||..|.:    |||.....
Mouse   559 ------ASPASLPAPSSNPLLESL---------KKMQESPAPSSSEPAEAATVAAPSPPKTPSLL 608

  Fly   597 KP-VTPATSSQPLISFGTPKSTAAPSFSFGSATNTTSSTIANITNTTTSKPIFSFGQTPANGPTV 660
            .| |:|...  ||.|..:....||......||        ::||..|.||.
Mouse   609 APLVSPLAG--PLASTSSDSKPAATFLGLASA--------SSITPLTDSKS-------------- 649

  Fly   661 GGLSGFKTEAPATTSVSTTNPGTQVTSTTTFGVTPPKTTTTVAPTTTVSLNFGQPMPSFGAADTG 725
            .|:|  :.|...:|..||.:..|...|.....::||.:::::|          .|.|:..:
Mouse   650 SGVS--QAEQSVSTPASTASSPTPKPSMLFGMLSPPASSSSLA----------TPAPACAS---- 698

  Fly   726 VKPMFS--FGKSNNLSSGTPTTNGSDAAAAKPAVFSFGGSTTQPAAAAPTPVFGSL--------S 780
              |||.  |..:....|.:|..:.|.||.      :...||..|.||:.||.|..:        :
Mouse   699 --PMFKPIFPATPKSESDSPLPSSSSAAT------TASSSTAPPTAASTTPTFKPIFDKMEPFTA 755

  Fly   781 KPLGEGFA----SPGANKSETTKPSIFGNLDNGLGNAMKSSTNVAATTAAELPKP-FGFAATTTA 840
            .||...|:    :..|..:.|:.|     |..|||.|   ::.||:.|||...|| |||..||.|
Mouse   756 MPLSTPFSLKQTTATATTTATSAP-----LFTGLGTA---TSTVASGTAASASKPVFGFGVTTAA 812

  Fly   841 AGGGSTATNLFS---FGGT--ATSKAAEPAPASQKNLFGLNATTTTPFAFGGAAAGAADKSENKD 900
            :...||.|:...   |||.  .|:.::.||.||             .|.||...|.||..:....
Mouse   813 STASSTMTSTSQSVLFGGAPPVTTSSSAPALAS-------------IFQFGKPLAPAASAAGTSF 864

  Fly   901 NKPIAFAFGAGNNSAVANPSGVFSFGG--TDKSAPPAFGSGTTSVTSATATPTNNTFGFSTTQKP 963
            ::|:     |.:....|:.||...||.  |..::.||..|..|...|.|.|||.| ..||::.||
Mouse   865 SQPL-----ASSTQTAASNSGFSGFGSTLTTSTSAPATTSQPTLTFSNTVTPTFN-IPFSSSAKP 923

  Fly   964 ATPMFGSGSTQQSSTPAVAATKP---------FTLGGGAPTTPSASPASGGFSFSAVATKNTTAP 1019
            |.|.:...::|.:......||||         ||.|....:.|||:||...|
Mouse   924 ALPTYPGANSQPTFGATDGATKPALAPSFGSSFTFGNSVASAPSAAPAPATF------------- 975

  Fly  1020 TAGTNLFGSPASASKPSFNFGGNTATQAAAAGSPAGGFSFATTTKKEDSASTNMFGSPNTGVVKP 1084
                      .||::|:|   |.....|:..|:||              ::...||| .|.|
Mouse   976 ----------GSAAQPAF---GGLKAAASTFGAPA--------------STQPAFGS-TTSV--- 1009

  Fly  1085 NFSFSSNNPTPAPTFGGFGAPAAAAPTATSTNQ-SKPFAFGASTPA----AAPQPPLGGNLFANA 1144
             |||.|      .|..||||.|.||.|..:||. |....||:|.|:    .....|.|...|  .
Mouse  1010 -FSFGS------ATTSGFGAAATAATTTQTTNSGSSSSLFGSSAPSPFTFGGSAAPAGSGGF--G 1065

  Fly  1145 VSATQNQTKPSGVFSFGAAKS-TAGTTAGNAPFSFGGASAGGIASPPSNQGLNTAKPFSFG-GA- 1206
            :|||...:..||.||||:.:| |.|||.     |||..|...:.:|  :||    .||:|. |:
Mouse  1066 LSATPGTSSTSGTFSFGSGQSGTPGTTT-----SFGSLSQNTLGAP--SQG----SPFAFSVGST 1119

  Fly  1207 -------GGTPAPNVFGSPAPAP------------PASNPTGGF----NFGGVSPAQQANAGNMF 1248
                   |||..| .||..||||            .:|.|..||    .||..:|:....||
Mouse  1120 PESKPVFGGTSTP-TFGQSAPAPGVGTTGSSLSFGASSTPAQGFVGVGPFGSAAPSFSIGAG--- 1180

  Fly  1249 APTPESRPIRKATRR 1263
            :.||.:|...:|.|:
Mouse  1181 SKTPGARQRLQARRQ 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14712	NP_650096.1	Nucleoporin_FG2	954..>1180	CDD:292589	73/240 (30%)
Pom121	NP_683734.2	Cisternal side. /evidence=ECO:0000255	1..56
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Pore side. /evidence=ECO:0000255	76..1200		347/1380 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..167		20/99 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..196		7/23 (30%)
		POM121	292..527	CDD:291882	61/280 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..328		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..509		47/191 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..627		30/130 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..692		16/77 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	706..744		12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1075..1151		32/87 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1173..1200		8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23193
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100