DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF566

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001138815.1	Gene:	ZNF566 / 84924	HGNCID:	25919	Length:	419	Species:	Homo sapiens

Alignment Length:	154	Identity:	57/154 - (37%)
Similarity:	81/154 - (52%)	Gaps:	4/154 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 TSLNHQKSIGGGTGPYVCPDCGRIINNKSNFQEHTLRHTGIKNFHCVFLNCERSFATRKELTSHT 191
            :.|.....|..|..||.|.:||:..::.|||..|...|||.|.:.|  ..|.::|::....|.|.
Human   241 SDLTRHHRIHTGEKPYECKECGKAFSSGSNFTRHQRIHTGEKPYEC--KECGKAFSSGSNFTQHQ 303

  Fly   192 RIHTGEQPYVCVYCPRRFSSSGARQEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIHVDARNH 256
            ||||||:||.|..|...||.|....:|.|.|..|:.|||..|:|:|.|...|.:|:.||...:.:
Human   304 RIHTGEKPYECKECGNAFSQSSQLIKHQRIHTGEKPYECKECEKAFRSGSDLTRHQRIHTGEKPY 368

  Fly   257 YCYVCQKHFKRISHLMTHLSSNIH 280
            .|.:|.|.:.:.|.|::|  ..||
Human   369 ECKICGKAYSQSSQLISH--HRIH 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071
		C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		C2H2 Zn finger	172..194	CDD:275368	6/21 (29%)
		zf-H2C2_2	186..211	CDD:290200	13/24 (54%)
		UFD2	<256..>294	CDD:227443	8/25 (32%)
		C2H2 Zn finger	258..280	CDD:275368	6/21 (29%)
ZNF566	NP_001138815.1	KRAB	6..66	CDD:214630
		KRAB	6..45	CDD:279668
		COG5048	<154..330	CDD:227381	34/90 (38%)
		zf-C2H2	200..222	CDD:278523
		C2H2 Zn finger	202..222	CDD:275368
		zf-H2C2_2	215..237	CDD:290200
		C2H2 Zn finger	230..250	CDD:275368	1/8 (13%)
		zf-H2C2_2	242..267	CDD:290200	8/24 (33%)
		COG5048	<254..405	CDD:227381	54/141 (38%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		zf-H2C2_2	270..295	CDD:290200	10/26 (38%)
		C2H2 Zn finger	286..306	CDD:275368	6/21 (29%)
		zf-H2C2_2	298..323	CDD:290200	13/24 (54%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		zf-H2C2_2	327..351	CDD:290200	10/23 (43%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	354..379	CDD:290200	7/24 (29%)
		C2H2 Zn finger	370..390	CDD:275368	6/21 (29%)
		C2H2 Zn finger	398..417	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050