DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6813 and ZNF496

DIOPT Version :9

Sequence 1:NP_001163590.1 Gene:CG6813 / 41396 FlyBaseID:FBgn0037923 Length:294 Species:Drosophila melanogaster
Sequence 2:NP_116141.1 Gene:ZNF496 / 84838 HGNCID:23713 Length:587 Species:Homo sapiens


Alignment Length:282 Identity:60/282 - (21%)
Similarity:101/282 - (35%) Gaps:66/282 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 IAEKQNLERIECDSKDCSTDPIIYEDI-----DDNQIESELDESI------------------LC 109
            :.|::..|.::..........::.::.     :...:|:.|||.:                  .|
Human   307 VEERRKREELQVPEFQACPQTVVPQNTYPAGGNPRSLENSLDEEVTIEIVLSSSGDEDSQHGPYC 371

  Fly   110 PEVKDLPMPSAEKVSAPTSLNHQKSIGG----GTGPYVCPDCGRIINNKSNFQEH-TLRHTGIKN 169
            .|  :|..|:.::.|.|.|.......||    ....||||:||:|...:.||..| ..|....|.
Human   372 TE--ELGSPTEKQRSLPASHRSSTEAGGEVQTSKKSYVCPNCGKIFRWRVNFIRHLRSRREQEKP 434

  Fly   170 FHCVFLNCERSFATRKELTSHTRIHTGEQPYVCVYCPRRFSSSGARQEHHRRHRN-------ERR 227
            ..|..  |...|:..::|..|...|..::||.|..|.:.|..:.....|.|.|..       |:|
Human   435 HECSV--CGELFSDSEDLDGHLESHEAQKPYRCGACGKSFRLNSHLLSHRRIHLQPDRLQPVEKR 497

  Fly   228 ------------------------YECDTCKKSFVSSGCLRKHKM-IHV--DARNHYCYVCQKHF 265
                                    ::|..|.|:|.....|.:|:. .|:  .||...|..|.|.|
Human   498 EQAASEDADKGPKEPLENGKAKLSFQCCECGKAFQRHDHLARHRSHFHLKDKARPFQCRYCVKSF 562

  Fly   266 KRISHLMTHLSSNIHKRKEEKL 287
            .:...|:.|...::.:|.::.|
Human   563 TQNYDLLRHERLHMKRRSKQAL 584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6813NP_001163590.1 zf-AD 6..76 CDD:285071 1/7 (14%)
C2H2 Zn finger 144..164 CDD:275368 8/20 (40%)
C2H2 Zn finger 172..194 CDD:275368 5/21 (24%)
zf-H2C2_2 186..211 CDD:290200 8/24 (33%)
UFD2 <256..>294 CDD:227443 8/32 (25%)
C2H2 Zn finger 258..280 CDD:275368 6/21 (29%)
ZNF496NP_116141.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
SCAN 50..126 CDD:280241
KRAB_A-box 222..259 CDD:143639
KRAB 223..275 CDD:214630
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 260..282
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 358..399 9/42 (21%)
C2H2 Zn finger 408..428 CDD:275368 8/19 (42%)
COG5048 <427..>586 CDD:227381 35/160 (22%)
C2H2 Zn finger 437..457 CDD:275368 5/21 (24%)
zf-C2H2 463..485 CDD:278523 6/21 (29%)
C2H2 Zn finger 465..485 CDD:275368 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..513 2/24 (8%)
zf-C2H2 522..543 CDD:278523 6/20 (30%)
C2H2 Zn finger 524..543 CDD:275368 6/18 (33%)
zf-C2H2 553..575 CDD:278523 6/21 (29%)
C2H2 Zn finger 555..575 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 123 1.000 Inparanoid score I4733
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.050

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