DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF140

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	XP_011533135.1	Gene:	ZNF140 / 7699	HGNCID:	12925	Length:	458	Species:	Homo sapiens

Alignment Length:	153	Identity:	56/153 - (36%)
Similarity:	80/153 - (52%)	Gaps:	5/153 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 HQKSIGGGTGPYVCPDCGRIINNKSNFQEHTLRHTGIKNFHCVFLNCERSFATRKELTSHTRIHT 195
            ||:: ..|..||.|.:||:..:..||..:|.:.|||.|...|  .:|.::|:....|..|.|.||
Human   180 HQRT-HTGEKPYACKECGKTFSQISNLVKHQMIHTGKKPHEC--KDCNKTFSYLSFLIEHQRTHT 241

  Fly   196 GEQPYVCVYCPRRFSSSGARQEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIHVDARNHYCYV 260
            ||:||.|..|.:.||.:.....|.|.|..:::|.|..|.|:|.|...|.:|::.|...:.:.|..
Human   242 GEKPYECTECGKAFSRASNLTRHQRIHIGKKQYICRKCGKAFSSGSELIRHQITHTGEKPYECIE 306

  Fly   261 CQKHFKRISHLMTHLSSNIHKRK 283
            |.|.|:|.|||..|.|  ||..|
Human   307 CGKAFRRFSHLTRHQS--IHTTK 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071
		C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		C2H2 Zn finger	172..194	CDD:275368	6/21 (29%)
		zf-H2C2_2	186..211	CDD:290200	12/24 (50%)
		UFD2	<256..>294	CDD:227443	13/28 (46%)
		C2H2 Zn finger	258..280	CDD:275368	10/21 (48%)
ZNF140	XP_011533135.1	KRAB	6..66	CDD:214630
		KRAB	6..45	CDD:279668
		COG5048	160..>453	CDD:227381	56/153 (37%)
		C2H2 Zn finger	164..184	CDD:275368	2/4 (50%)
		zf-H2C2_2	176..201	CDD:290200	8/21 (38%)
		C2H2 Zn finger	192..212	CDD:275368	6/19 (32%)
		zf-H2C2_2	204..229	CDD:290200	9/26 (35%)
		C2H2 Zn finger	220..240	CDD:275368	6/21 (29%)
		zf-H2C2_2	233..257	CDD:290200	12/23 (52%)
		C2H2 Zn finger	248..268	CDD:275368	6/19 (32%)
		zf-H2C2_2	260..285	CDD:290200	8/24 (33%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	288..313	CDD:290200	7/24 (29%)
		C2H2 Zn finger	304..324	CDD:275368	10/21 (48%)
		C2H2 Zn finger	332..352	CDD:275368
		C2H2 Zn finger	360..380	CDD:275368
		zf-H2C2_2	372..397	CDD:290200
		C2H2 Zn finger	388..408	CDD:275368
		zf-H2C2_2	400..424	CDD:290200
		C2H2 Zn finger	416..436	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050