DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF124

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001284497.1	Gene:	ZNF124 / 7678	HGNCID:	12907	Length:	351	Species:	Homo sapiens

Alignment Length:	222	Identity:	65/222 - (29%)
Similarity:	96/222 - (43%)	Gaps:	35/222 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 IYEDI---------------DDNQIESELDES------IL---------CPEV--KDLPMPSAEK 122
            :|.|:               :|..||.:...|      |:         |.|.  |.......:|
Human    37 LYRDVMQETFRNLASIGNKGEDQSIEDQYKNSSRNLRHIISHSGNNPYGCEECGKKPCTCKQCQK 101

  Fly   123 VSAPTSLNHQKSI-GGGTGPYVCPDCGRIINNKSNFQEHTLRHTGIKNFHCVFLNCERSFATRKE 186
            .|...:..|:.:: ..|.|.|.|..|.::.|..|:||.|...|||.|.:.|  :.|.::....:.
Human   102 TSLSVTRVHRDTVMHTGNGHYGCTICEKVFNIPSSFQIHQRNHTGEKPYEC--MECGKALGFSRS 164

  Fly   187 LTSHTRIHTGEQPYVCVYCPRRFSSSGARQEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIHV 251
            |..|.||||||:.|.|..|.:.||.|...::|.|.|..|:.|||..|.|:|..|.||..|:..|.
Human   165 LNRHKRIHTGEKRYECKQCGKAFSRSSHLRDHERTHTGEKPYECKHCGKAFRYSNCLHYHERTHT 229

  Fly   252 DARNHYCYVCQKHFKRISHLMTHLSSN 278
            ..:.:.|..|.|.|..:|.|..|:.::
Human   230 GEKPYVCMECGKAFSCLSSLQGHIKAH 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071
		C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		C2H2 Zn finger	172..194	CDD:275368	5/21 (24%)
		zf-H2C2_2	186..211	CDD:290200	12/24 (50%)
		UFD2	<256..>294	CDD:227443	7/23 (30%)
		C2H2 Zn finger	258..280	CDD:275368	7/21 (33%)
ZNF124	NP_001284497.1	KRAB	12..53	CDD:307490	2/15 (13%)
		C2H2 Zn finger	96..116	CDD:275368	3/19 (16%)
		C2H2 Zn finger	124..144	CDD:275368	7/19 (37%)
		C2H2 Zn finger	152..172	CDD:275368	5/21 (24%)
		COG5048	<176..338	CDD:227381	28/81 (35%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	264..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368
		C2H2 Zn finger	320..340	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960