DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and MZF1

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	XP_005259261.1	Gene:	MZF1 / 7593	HGNCID:	13108	Length:	775	Species:	Homo sapiens

Alignment Length:	352	Identity:	86/352 - (24%)
Similarity:	131/352 - (37%)	Gaps:	103/352 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRICSRSDAPIDLFGPGNGHLVRQIHSITGVE---LSC----------------KKEISGQMCTT 51
            |..|.||.:       .:.||:|  |.:|..|   ..|                ::..:|:....
Human   427 CSECGRSFS-------RSSHLLR--HQLTHTEERPFVCGDCGQGFVRSARLEEHRRVHTGEQPFR 482

  Fly    52 CLDNLQAAIKFRQRCIIAEKQNLERIECDSKDCSTDP--------------------------II 90
            |.:..|:   ||||..:.:.|   ||..|.......|                          ::
Human   483 CAECGQS---FRQRSNLLQHQ---RIHGDPPGPGAKPPAPPGAPEPPGPFPCSECRESFARRAVL 541

  Fly    91 YEDIDDNQIESELDESILCPEVKDLPMPSAEKVSAPTSLNHQKSIGGGTGPYVCPDCGRIINNKS 155
            .|    :|.....|:|..|.|       ..|:....:.|...:.:..|..|:.|.:||:....:|
Human   542 LE----HQAVHTGDKSFGCVE-------CGERFGRRSVLLQHRRVHSGERPFACAECGQSFRQRS 595

  Fly   156 NFQEHTLRHTGIKNFHCVFLNCERSFATRKELTSHTRIHTGEQPYVCVYCPRRFSS--------- 211
            |..:|...|||.:.|.|.  .|.::|..|..||.|.|:||||:|:.|..|.:|||.
Human   596 NLTQHRRIHTGERPFACA--ECGKAFRQRPTLTQHLRVHTGEKPFACPECGQRFSQRLKLTRHQR 658

  Fly   212 --SGAR-----------------QEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIHVDARNHY 257
              :|.:                 .||.|.|..||.:.|..|.:||.....|.:|:.||...|.:.
Human   659 THTGEKPYHCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHANLTQHRRIHTGERPYA 723

  Fly   258 CYVCQKHFKRISHLMTHLSSNIHKRKE 284
            |..|.|.|::...|..||.:  |:|::
Human   724 CPECGKAFRQRPTLTQHLRT--HRREK 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071	19/88 (22%)
		C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		C2H2 Zn finger	172..194	CDD:275368	8/21 (38%)
		zf-H2C2_2	186..211	CDD:290200	13/24 (54%)
		UFD2	<256..>294	CDD:227443	9/29 (31%)
		C2H2 Zn finger	258..280	CDD:275368	7/21 (33%)
MZF1	XP_005259261.1	SCAN	81..193	CDD:128708
		COG5048	399..757	CDD:227381	86/352 (24%)
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368	8/28 (29%)
		C2H2 Zn finger	455..475	CDD:275368	1/19 (5%)
		C2H2 Zn finger	483..503	CDD:275370	8/25 (32%)
		C2H2 Zn finger	528..548	CDD:275368	2/23 (9%)
		C2H2 Zn finger	556..576	CDD:275368	4/26 (15%)
		C2H2 Zn finger	584..604	CDD:275368	6/19 (32%)
		C2H2 Zn finger	612..632	CDD:275368	8/21 (38%)
		C2H2 Zn finger	640..660	CDD:275368	5/19 (26%)
		C2H2 Zn finger	668..688	CDD:275368	3/19 (16%)
		C2H2 Zn finger	696..716	CDD:275368	6/19 (32%)
		C2H2 Zn finger	724..744	CDD:275368	7/21 (33%)
		C2H2 Zn finger	752..772	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050