DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZKSCAN1

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001333510.1	Gene:	ZKSCAN1 / 7586	HGNCID:	13101	Length:	563	Species:	Homo sapiens

Alignment Length:	161	Identity:	56/161 - (34%)
Similarity:	82/161 - (50%)	Gaps:	4/161 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 SAPTSLNHQKSIGGGTGPYVCPDCGRIINNKSNFQEHTLRHTGIKNFHCVFLNCERSFATRKELT 188
            |..::....:.:..||..:.|.:||:.....|:...|.:.|||.|.:.|  ..|.::|:....|.
Human   359 SLSSNFTTPEEVPTGTKSHRCDECGKCFTRSSSLIRHKIIHTGEKPYEC--SECGKAFSLNSNLV 421

  Fly   189 SHTRIHTGEQPYVCVYCPRRFSSSGARQEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIHVDA 253
            .|.||||||:|:.|..|.:.||.|.....|.|.|..|:.|||:.|.|:|..|..|.||:.||...
Human   422 LHQRIHTGEKPHECNECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQRIHTGE 486

  Fly   254 RNHYCYVCQKHFKRISHLMTHLSSNIHKRKE 284
            :.:.|..|.|.|.|.|:|:.|  ..||.|::
Human   487 KPYECSECGKAFNRNSYLILH--RRIHTREK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071
		C2H2 Zn finger	144..164	CDD:275368	5/19 (26%)
		C2H2 Zn finger	172..194	CDD:275368	6/21 (29%)
		zf-H2C2_2	186..211	CDD:290200	12/24 (50%)
		UFD2	<256..>294	CDD:227443	11/29 (38%)
		C2H2 Zn finger	258..280	CDD:275368	8/21 (38%)
ZKSCAN1	NP_001333510.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		SCAN	52..162	CDD:128708
		KRAB_A-box	227..262	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..373		1/13 (8%)
		C2H2 Zn finger	355..371	CDD:275368	1/11 (9%)
		COG5048	<356..537	CDD:227381	56/161 (35%)
		C2H2 Zn finger	379..399	CDD:275368	5/19 (26%)
		C2H2 Zn finger	407..427	CDD:275368	6/21 (29%)
		C2H2 Zn finger	435..455	CDD:275368	7/19 (37%)
		C2H2 Zn finger	463..483	CDD:275368	8/19 (42%)
		C2H2 Zn finger	491..511	CDD:275368	8/21 (38%)
		C2H2 Zn finger	519..539	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050