DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF10

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_056209.2	Gene:	ZNF10 / 7556	HGNCID:	12879	Length:	573	Species:	Homo sapiens

Alignment Length:	187	Identity:	62/187 - (33%)
Similarity:	89/187 - (47%)	Gaps:	20/187 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 DESILCPEVKDLPMPSAEKVSAPTSLNHQKSIGGGTG-----PYVCPDCGRIINNKSNFQEHTLR 163
            |:|..||:             ...||.|..|:|...|     ||.|.:||:..:.:||...|.|.
Human   235 DKSYKCPD-------------NDNSLTHGSSLGISKGIHREKPYECKECGKFFSWRSNLTRHQLI 286

  Fly   164 HTGIKNFHCVFLNCERSFATRKELTSHTRIHTGEQPYVCVYCPRRFSSSGARQEHHRRHRNERRY 228
            |||.|.:.|  ..|.:||:....|..|.:.||||:||.|..|.:.||.......|.|.|..::.|
Human   287 HTGEKPYEC--KECGKSFSRSSHLIGHQKTHTGEEPYECKECGKSFSWFSHLVTHQRTHTGDKLY 349

  Fly   229 ECDTCKKSFVSSGCLRKHKMIHVDARNHYCYVCQKHFKRISHLMTHLSSNIHKRKEE 285
            .|:.|.||||.|..|.:|:..|...:.:.|..|.|.|::.:||:.|..:::..|..|
Human   350 TCNQCGKSFVHSSRLIRHQRTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVRPYE 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071
		C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		C2H2 Zn finger	172..194	CDD:275368	6/21 (29%)
		zf-H2C2_2	186..211	CDD:290200	11/24 (46%)
		UFD2	<256..>294	CDD:227443	9/30 (30%)
		C2H2 Zn finger	258..280	CDD:275368	7/21 (33%)
ZNF10	NP_056209.2	KRAB	14..73	CDD:214630
		C2H2 Zn finger	213..232	CDD:275368
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		COG5048	<272..474	CDD:227381	47/137 (34%)
		C2H2 Zn finger	295..315	CDD:275368	6/21 (29%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..371	CDD:275368	9/19 (47%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	407..427	CDD:275368	62/187 (33%)
		C2H2 Zn finger	435..455	CDD:275368
		C2H2 Zn finger	463..483	CDD:275368
		C2H2 Zn finger	491..511	CDD:275368
		C2H2 Zn finger	519..539	CDD:275368
		C2H2 Zn finger	547..567	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050