DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF662

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001128128.1	Gene:	ZNF662 / 389114	HGNCID:	31930	Length:	452	Species:	Homo sapiens

Alignment Length:	265	Identity:	80/265 - (30%)
Similarity:	108/265 - (40%)	Gaps:	53/265 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 FRQRCIIAEKQNLER----IECDSKDCSTDPIIYEDIDDNQIESE------------------LD 104
            |.:.|  .||..|.|    :.....:.||:.||...:.|..|..|                  |:
Human   151 FGKTC--EEKSRLGRWPGYLNGGRMESSTNDIIEVIVKDEMISVEESSGNTDVNNLLGIHHKILN 213

  Fly   105 ESI--LCPEV-------KDLPM----PSAEKVSA-----------PTSLNHQKSIGGGTGPYVCP 145
            |.|  :|.|.       :|...    .:.|||..           ...:.||: |..|..||.|.
Human   214 EQIFYICEECGKCFDQNEDFDQHQKTHNGEKVYGCKECGKAFSFRSHCIAHQR-IHSGVKPYECQ 277

  Fly   146 DCGRIINNKSNFQEHTLRHTGIKNFHCVFLNCERSFATRKELTSHTRIHTGEQPYVCVYCPRRFS 210
            :|.:....|||...|...|||.|.|.|  ..|.:.|:....||.|.||||||:||.|..|.:.|:
Human   278 ECAKAFVWKSNLIRHQRIHTGEKPFEC--KECGKGFSQNTSLTQHQRIHTGEKPYTCKECGKSFT 340

  Fly   211 SSGARQEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIHVDARNHYCYVCQKHFKRISHLMTHL 275
            .:.|...|.|.|..|:.|||..|.|.|:.:..|.:|:.:|...:.|.|..|.|.|...:||:.|
Human   341 RNPALLRHQRMHTGEKPYECKDCGKGFMWNSDLSQHQRVHTGDKPHECTDCGKSFFCKAHLIRH- 404

  Fly   276 SSNIH 280
             ..||
Human   405 -QRIH 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071	5/13 (38%)
		C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		C2H2 Zn finger	172..194	CDD:275368	7/21 (33%)
		zf-H2C2_2	186..211	CDD:290200	14/24 (58%)
		UFD2	<256..>294	CDD:227443	10/25 (40%)
		C2H2 Zn finger	258..280	CDD:275368	7/21 (33%)
ZNF662	NP_001128128.1	KRAB	33..92	CDD:214630
		KRAB	33..72	CDD:279668
		C2H2 Zn finger	220..240	CDD:275368	3/19 (16%)
		C2H2 Zn finger	248..268	CDD:275368	2/20 (10%)
		zf-H2C2_2	264..284	CDD:290200	8/20 (40%)
		COG5048	<272..427	CDD:227381	54/141 (38%)
		C2H2 Zn finger	276..296	CDD:275368	6/19 (32%)
		zf-H2C2_2	288..313	CDD:290200	10/26 (38%)
		C2H2 Zn finger	304..324	CDD:275368	7/21 (33%)
		zf-H2C2_2	316..341	CDD:290200	14/24 (58%)
		C2H2 Zn finger	332..352	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..367	CDD:290200	10/22 (45%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	372..395	CDD:290200	7/22 (32%)
		C2H2 Zn finger	388..408	CDD:275368	7/21 (33%)
		zf-H2C2_2	400..425	CDD:290200	5/11 (45%)
		C2H2 Zn finger	416..436	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050