DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6813 and ZFP69

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001307107.1	Gene:	ZFP69 / 339559	HGNCID:	24708	Length:	527	Species:	Homo sapiens

Alignment Length:	280	Identity:	75/280 - (26%)
Similarity:	106/280 - (37%)	Gaps:	72/280 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TCLDNLQAAI-----------KFRQRCIIAE----KQNLERIECDSK------DCSTDPIIYEDI 94
            ||:.:::.||           ||.:..|:..    :|...:.:..:|      |....|..|
Human   205 TCMRDVRQAILTHKKRVQETNKFGENIIVHSNVIIEQRHHKYDTPTKRNTYKLDLINHPTSY--- 266

  Fly    95 DDNQIESELDESILCPEVKDLPMPSAEKV-SAPTSLNHQKSIGGGTGPYVCPDCGRIINNKSNFQ 158
                |.::..|..:|           ||: ..|..|.....|..|..|:.|.:|||..:..::..
Human   267 ----IRTKTYECNIC-----------EKIFKQPIHLTEHMRIHTGEKPFRCKECGRAFSQSASLS 316

  Fly   159 EHTLRHTGIKNFHCVFLNCERSFATRKELTSHTRIHTGEQPYVCVYCPRRFSS-----------S 212
            .|...|||.|.|.|.  .|.::|..|..|..|.|.||||:||||..|.:.||.           |
Human   317 THQRIHTGEKPFECE--ECGKAFRHRSSLNQHHRTHTGEKPYVCDKCQKAFSQNISLVQHLRTHS 379

  Fly   213 GAR-----------------QEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIHVDARNHYCYV 260
            |.:                 .||.|.|..|:.|.|..|.|:|.....|..|:.||...|.:.|..
Human   380 GEKPFTCNECGKTFRQIRHLSEHIRIHTGEKPYACTACCKTFSHRAYLTHHQRIHTGERPYKCKE 444

  Fly   261 CQKHFKRISHLMTHLSSNIH 280
            |.|.|::..||..|  ..:|
Human   445 CGKAFRQRIHLSNH--KTVH 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071	8/39 (21%)
		C2H2 Zn finger	144..164	CDD:275368	5/19 (26%)
		C2H2 Zn finger	172..194	CDD:275368	7/21 (33%)
		zf-H2C2_2	186..211	CDD:290200	13/24 (54%)
		UFD2	<256..>294	CDD:227443	8/25 (32%)
		C2H2 Zn finger	258..280	CDD:275368	7/21 (33%)
ZFP69	NP_001307107.1	SCAN	<3..66	CDD:383046
		KRAB	76..137	CDD:214630
		COG5048	<233..516	CDD:227381	68/252 (27%)
		C2H2 Zn finger	274..294	CDD:275368	5/30 (17%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	7/21 (33%)
		C2H2 Zn finger	358..378	CDD:275368	4/19 (21%)
		C2H2 Zn finger	386..406	CDD:275368	3/19 (16%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		C2H2 Zn finger	442..462	CDD:275368	7/21 (33%)
		C2H2 Zn finger	498..518	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050