DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF789

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_998768.2	Gene:	ZNF789 / 285989	HGNCID:	27801	Length:	425	Species:	Homo sapiens

Alignment Length:	160	Identity:	51/160 - (31%)
Similarity:	74/160 - (46%)	Gaps:	7/160 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 LNHQKSIGGGTGPYVCPDCGRIINNKSNFQEHTLRHTGIKNFHCVFLNCERSFATRKELTSHTRI 193
            |.|::.:..... |.|.:||::|..|:.|.:|...|.....|.|..  |.::|..|..||.|.:.
Human   189 LGHERILTRAKS-YECSECGKVIRRKAWFDQHQRIHFLENPFECKV--CGQAFRQRSALTVHKQC 250

  Fly   194 HTGEQPYVCVYCPRRFSSSGARQEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIHVDARNHYC 258
            |...:||.|..|.:.|.......||.|.|..|:.|:|..|:|:|..:..|.:|::||...:.|.|
Human   251 HLQNKPYRCHDCGKCFRQLAYLVEHKRIHTKEKPYKCSKCEKTFSQNSTLIRHQVIHSGEKRHKC 315

  Fly   259 YVCQKHFKR----ISHLMTHLSSNIHKRKE 284
            ..|.|.|.|    :.|...|...|.||..|
Human   316 LECGKAFGRHSTLLCHQQIHSKPNTHKCSE 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071
		C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		C2H2 Zn finger	172..194	CDD:275368	7/21 (33%)
		zf-H2C2_2	186..211	CDD:290200	9/24 (38%)
		UFD2	<256..>294	CDD:227443	12/33 (36%)
		C2H2 Zn finger	258..280	CDD:275368	8/25 (32%)
ZNF789	NP_998768.2	KRAB	11..71	CDD:214630
		KRAB	11..50	CDD:279668
		COG5048	<179..303	CDD:227381	36/116 (31%)
		C2H2 Zn finger	179..195	CDD:275368	2/5 (40%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	7/21 (33%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		zf-H2C2_2	271..296	CDD:290200	10/24 (42%)
		COG5048	<283..420	CDD:227381	21/63 (33%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		C2H2 Zn finger	343..363	CDD:275368	1/3 (33%)
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050