Protein Alignment CG6813 and ZNF454

DIOPT Version :10

• Sequence 1: NP_001163590.1
• Gene: CG6813 / 41396
• FlyBaseID: FBgn0037923
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_872400.2
• Gene: ZNF454 / 285676
• HGNCID: 21200
• Length: 522
• Species: Homo sapiens
• Alignment Length: 329
• Identity: 91/329 - (27%)
• Similarity: 142/329 - (43%)
• Gaps: 76/329 - (23%)

  Fly     6 CRICSRSDAPIDLFGPGNGHLV--RQIHSITGVE-LSCKK-----EISGQM-------------- 48
            ||.|.::      |.... ||:  ::||  ||.: ..||:     .:|..:
Human   218 CRECGKA------FHQST-HLIHHQRIH--TGEKPYECKECGKAFSVSSSLTYHQKIHTGEKPFE 273

  Fly    49 CTTC----LDNLQAAIKFR-------QRCIIAEK-----------QNLERIECDSK--DC----- 84
            |..|    :.|:..|...|       .:|.|.||           ||:...|...|  :|
Human   274 CNLCGKAFIRNIHLAHHHRIHTGEKPFKCNICEKAFVCRAHLTKHQNIHSGEKPYKCNECGKAFN 338

  Fly    85 -STDPIIYEDIDDNQIESELDESILCPEVKDLPMPSAEKVSAPTSLNHQKSIGGGTGPYVCPDCG 148
             ||..:.::.|...:...|.:|   |.:        |.:|:  :||...:.|..|..||.|.:||
Human   339 QSTSFLQHQRIHTGEKPFECNE---CGK--------AFRVN--SSLTEHQRIHTGEKPYKCNECG 390

  Fly   149 RIINNKSNFQEHTLRHTGIKNFHCVFLNCERSFATRKELTSHTRIHTGEQPYVCVYCPRRFSSSG 213
            :...:.|:|..|...|||.|.:.|..  ||::|..:..|..|.||||||:||.|..|.:.||...
Human   391 KAFRDNSSFARHRKIHTGEKPYRCGL--CEKAFRDQSALAQHQRIHTGEKPYTCNICEKAFSDHS 453

  Fly   214 ARQEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIHVDARNHYCYVCQKHFKRISHLMTHLSSN 278
            |..:|.|.|..|:.|:|..|:|:|:.|..|.:|:.||...:.:.|..|.|.|.:.::|:.|...:
Human   454 ALTQHKRIHTREKPYKCKICEKAFIRSTHLTQHQRIHTGEKPYKCNKCGKAFNQTANLIQHQRHH 518

  Fly   279 IHKR 282
            |.::
Human   519 IGEK 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	5..76	CDD:462262	24/113 (21%)
		C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		C2H2 Zn finger	172..194	CDD:275368	7/21 (33%)
		UFD2	<256..>294	CDD:227443	7/27 (26%)
		C2H2 Zn finger	258..280	CDD:275368	6/21 (29%)
ZNF454	NP_872400.2	KRAB	14..73	CDD:214630
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..170
		C2H2 Zn finger	180..200	CDD:275368
		COG5048	186..522	CDD:227381	91/327 (28%)
		C2H2 Zn finger	218..238	CDD:275368	6/26 (23%)
		C2H2 Zn finger	246..266	CDD:275368	3/19 (16%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	3/19 (16%)
		C2H2 Zn finger	358..378	CDD:275368	6/32 (19%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		C2H2 Zn finger	414..434	CDD:275368	7/21 (33%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		C2H2 Zn finger	470..490	CDD:275368	7/19 (37%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)