DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF621

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001091884.1	Gene:	ZNF621 / 285268	HGNCID:	24787	Length:	439	Species:	Homo sapiens

Alignment Length:	251	Identity:	66/251 - (26%)
Similarity:	100/251 - (39%)	Gaps:	58/251 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRILNCRICSRSDAPIDLFGPGNGHLVRQIHSITGVE-LSCKKEISGQMCTTCLDNLQAAIKFRQ 64
            |:...|:.|.:      :| ..|..|:|...|.||.: ..||:         |    ..|.|...
Human   148 MKFYECKECGK------IF-RYNSKLIRHQMSHTGEKPFKCKE---------C----GKAFKSSY 192

  Fly    65 RCIIAEKQNLERIECDSKDCSTDPIIYEDIDDNQIESELDESILCPEVKDLPMPSAEKVSAPTSL 129
            .||:.||.::.....:.|:|                                   .:.:|:.|:|
Human   193 DCIVHEKNHIGEGPYECKEC-----------------------------------GKGLSSNTAL 222

  Fly   130 NHQKSIGGGTGPYVCPDCGRIINNKSNFQEHTLRHTGIKNFHCVFLNCERSFATRKELTSHTRIH 194
            ...:.|..|..||.|.:||:.....:.:.:|...|||.|.:.|  ..|.::|..|.....|.|||
Human   223 TQHQRIHTGEKPYECKECGKAFRRSAAYLQHQRLHTGEKLYKC--KECWKAFGCRSLFIVHQRIH 285

  Fly   195 TGEQPYVCVYCPRRFSSSGARQEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIH 250
            |||:||.|..|.:.|:...|..:|.|.|..|:.|||..|.|:|...|...:|:.:|
Human   286 TGEKPYQCKECGKAFTQKIASIQHQRVHTGEKPYECKVCGKAFKWYGSFVQHQKLH 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071	18/70 (26%)
		C2H2 Zn finger	144..164	CDD:275368	4/19 (21%)
		C2H2 Zn finger	172..194	CDD:275368	6/21 (29%)
		zf-H2C2_2	186..211	CDD:290200	12/24 (50%)
		UFD2	<256..>294	CDD:227443
		C2H2 Zn finger	258..280	CDD:275368
ZNF621	NP_001091884.1	KRAB	11..71	CDD:214630
		COG4049	145..198	CDD:226535	17/69 (25%)
		C2H2 Zn finger	153..173	CDD:275368	6/26 (23%)
		zf-H2C2_2	166..190	CDD:316026	9/36 (25%)
		C2H2 Zn finger	209..229	CDD:275368	5/54 (9%)
		zf-H2C2_2	221..246	CDD:316026	8/24 (33%)
		C2H2 Zn finger	237..257	CDD:275368	4/19 (21%)
		C2H2 Zn finger	265..285	CDD:275368	6/21 (29%)
		zf-H2C2_2	281..302	CDD:316026	12/20 (60%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
		zf-H2C2_2	308..329	CDD:316026	9/20 (45%)
		C2H2 Zn finger	321..341	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050