DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF500

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_067678.1	Gene:	ZNF500 / 26048	HGNCID:	23716	Length:	480	Species:	Homo sapiens

Alignment Length:	170	Identity:	55/170 - (32%)
Similarity:	83/170 - (48%)	Gaps:	9/170 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 VKDLPMPSAEKVSAPTSLNHQKSIGGGTGPYVCPDCGRIINNKSNFQEHTLRHTGIKNFHCVFLN 176
            |:.|..|...:...|..   :::..|...||.||:||:..:..|:..:|...|||.:.:.|  |.
Human   298 VRGLVRPDQPRGGPPPG---RRASHGADKPYTCPECGKGFSKTSHLTKHQRTHTGERPYKC--LV 357

  Fly   177 CERSFATRKELTSHTRIHTGEQPYVCVYCPRRFSSSGARQEHHRRHRNERRYECDTCKKSFVSSG 241
            |.:.|:.|...::|.|:||||:||.|..|.:|||.|.:...|.|.|..||.|.|..|.|.|.:|.
Human   358 CGKGFSDRSNFSTHQRVHTGEKPYPCPECGKRFSQSSSLVIHRRTHSGERPYACTQCGKRFNNSS 422

  Fly   242 CLRKHKMIHVDARNHYCYVCQKHFKR----ISHLMTHLSS 277
            ....|:..|...:.:.|..|.:.|:|    ..|..||:.:
Human   423 HFSAHRRTHTGEKPYTCPACGRGFRRGTDLHKHQRTHMGA 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071
		C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		C2H2 Zn finger	172..194	CDD:275368	7/21 (33%)
		zf-H2C2_2	186..211	CDD:290200	12/24 (50%)
		UFD2	<256..>294	CDD:227443	7/26 (27%)
		C2H2 Zn finger	258..280	CDD:275368	7/24 (29%)
ZNF500	NP_067678.1	SCAN	46..151	CDD:128708
		SCAN	46..134	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..208
		KRAB_A-box	224..>247	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..268
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..322		5/26 (19%)
		COG5048	<320..459	CDD:227381	49/140 (35%)
		zf-C2H2	325..347	CDD:278523	7/21 (33%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-H2C2_2	339..363	CDD:290200	7/25 (28%)
		C2H2 Zn finger	355..375	CDD:275368	7/21 (33%)
		zf-H2C2_2	367..392	CDD:290200	12/24 (50%)
		C2H2 Zn finger	383..403	CDD:275368	8/19 (42%)
		zf-H2C2_2	395..420	CDD:290200	10/24 (42%)
		C2H2 Zn finger	411..431	CDD:275368	6/19 (32%)
		zf-H2C2_2	423..448	CDD:290200	5/24 (21%)
		C2H2 Zn finger	439..459	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	453..480		3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050