DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF169

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_003439.2	Gene:	ZNF169 / 169841	HGNCID:	12957	Length:	604	Species:	Homo sapiens

Alignment Length:	178	Identity:	57/178 - (32%)
Similarity:	83/178 - (46%)	Gaps:	27/178 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 LCPEV-------KDLPMPSAEKVSAPTSLNHQKSIGGGTGPYVCPDCGRIINNKSNFQEHTLRHT 165
            :|||.       .||             :.||:: ..|..||:||:|||..:.|::...|..:|:
Human   236 VCPECGRGFCQRSDL-------------IKHQRT-HTGEKPYLCPECGRRFSQKASLSIHQRKHS 286

  Fly   166 GIKNFHCVFLNCERSFATRKELTSHTRIHTGEQPYVCVYCPRRFSSSGARQEHHRRHRNERRYEC 230
            |.|.:.|  ..|.|.|.....||:|.|||:||:|:||..|.|.|....|...|.|.|..|:.:.|
Human   287 GEKPYVC--RECGRHFRYTSSLTNHKRIHSGERPFVCQECGRGFRQKIALLLHQRTHLEEKPFVC 349

  Fly   231 DTCKKSFVSSGCLRKHKMIHVDARNHYCYVCQKHFKR----ISHLMTH 274
            ..|.:.|.....|.:|:..|...|...|..|.:.|::    :||.:||
Human   350 PECGRGFCQKASLLQHQSSHTGERPFLCLECGRSFRQQSLLLSHQVTH 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071
		C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		C2H2 Zn finger	172..194	CDD:275368	8/21 (38%)
		zf-H2C2_2	186..211	CDD:290200	14/24 (58%)
		UFD2	<256..>294	CDD:227443	7/23 (30%)
		C2H2 Zn finger	258..280	CDD:275368	7/21 (33%)
ZNF169	NP_003439.2	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..182
		COG5048	223..>584	CDD:227381	57/178 (32%)
		zf-C2H2	235..257	CDD:278523	7/34 (21%)
		C2H2 Zn finger	237..257	CDD:275368	7/33 (21%)
		zf-H2C2_2	249..274	CDD:290200	12/38 (32%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		zf-H2C2_2	277..302	CDD:290200	8/26 (31%)
		C2H2 Zn finger	293..313	CDD:275368	8/21 (38%)
		zf-H2C2_2	305..330	CDD:290200	14/24 (58%)
		C2H2 Zn finger	321..341	CDD:275368	7/19 (37%)
		C2H2 Zn finger	349..369	CDD:275368	5/19 (26%)
		C2H2 Zn finger	377..397	CDD:275368	5/19 (26%)
		zf-C2H2	403..425	CDD:278523
		C2H2 Zn finger	405..425	CDD:275368
		zf-H2C2_2	418..442	CDD:290200
		C2H2 Zn finger	433..453	CDD:275368
		zf-H2C2_2	449..468	CDD:290200
		C2H2 Zn finger	461..481	CDD:275368
		zf-H2C2_2	474..496	CDD:290200
		C2H2 Zn finger	489..509	CDD:275368
		C2H2 Zn finger	518..537	CDD:275368
		C2H2 Zn finger	545..565	CDD:275368
		zf-H2C2_2	557..582	CDD:290200
		C2H2 Zn finger	573..592	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050