DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF383

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001332876.1	Gene:	ZNF383 / 163087	HGNCID:	18609	Length:	475	Species:	Homo sapiens

Alignment Length:	276	Identity:	78/276 - (28%)
Similarity:	121/276 - (43%)	Gaps:	32/276 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRICSRSDAPIDLFGPGNGHLVRQIHSITGVE-LSCKKEISGQMCTTCLDNLQAAIKFRQRCIIA 69
            |:.|.:      .|..|: |:.|.:...||.: ..||:......|::.|..       .||....
Human   200 CKECGK------FFSCGS-HVTRHLKIHTGEKPFECKECGKAFSCSSYLSQ-------HQRIHTG 250

  Fly    70 EKQNLERIECDSKDCSTDPIIYEDIDDNQIESELDESILCPEVKDLPMPSAEKVSAPTSLNHQKS 134
            :|.    .||  |:|........::.|:|.....::...|       ....:..:..:.|.....
Human   251 KKP----YEC--KECGKAFSYCSNLIDHQRIHTGEKPYEC-------KVCGKAFTKSSQLFQHAR 302

  Fly   135 IGGGTGPYVCPDCGRIINNKSNFQEHTLRHTGIKNFHCVFLNCERSFATRKELTSHTRIHTGEQP 199
            |..|..||.|.:||:.....|...:|...|||.|.:.|  ..|.::|::...||:|.||||||:|
Human   303 IHTGEKPYECKECGKAFTQSSKLVQHQRIHTGEKPYEC--KECGKAFSSGSALTNHQRIHTGEKP 365

  Fly   200 YVCVYCPRRFSSSGARQEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIHVDARNHYCYVCQKH 264
            |.|..|.:.|:.|...::|.|.|..|:.:||..|.|:|..:..|.:|:.||.|.:.:.|..|.|.
Human   366 YDCKECGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRIHTDEKPYECNECGKA 430

  Fly   265 FKRISHLMTHLSSNIH 280
            |.:.|:|..||  .||
Human   431 FNKCSNLTRHL--RIH 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071	15/70 (21%)
		C2H2 Zn finger	144..164	CDD:275368	5/19 (26%)
		C2H2 Zn finger	172..194	CDD:275368	7/21 (33%)
		zf-H2C2_2	186..211	CDD:290200	14/24 (58%)
		UFD2	<256..>294	CDD:227443	10/25 (40%)
		C2H2 Zn finger	258..280	CDD:275368	8/21 (38%)
ZNF383	NP_001332876.1	KRAB	6..66	CDD:214630
		zf-C2H2	170..192	CDD:395048
		C2H2 Zn finger	172..192	CDD:275368
		zf-H2C2_2	187..209	CDD:404364	3/14 (21%)
		C2H2 Zn finger	200..220	CDD:275368	6/26 (23%)
		zf-H2C2_2	212..237	CDD:404364	6/24 (25%)
		C2H2 Zn finger	228..248	CDD:275368	6/26 (23%)
		COG5048	<231..475	CDD:227381	68/238 (29%)
		C2H2 Zn finger	256..276	CDD:275368	5/21 (24%)
		C2H2 Zn finger	284..304	CDD:275368	2/26 (8%)
		C2H2 Zn finger	312..332	CDD:275368	5/19 (26%)
		C2H2 Zn finger	340..360	CDD:275368	7/21 (33%)
		C2H2 Zn finger	368..388	CDD:275368	6/19 (32%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..444	CDD:275368	8/21 (38%)
		C2H2 Zn finger	452..472	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960