DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF565

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001035939.1	Gene:	ZNF565 / 147929	HGNCID:	26726	Length:	499	Species:	Homo sapiens

Alignment Length:	287	Identity:	84/287 - (29%)
Similarity:	116/287 - (40%)	Gaps:	46/287 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RILNCRICSRSDAPIDLFGPGNGHLV--RQIHSITGVE-LSCKKEISGQMCTTCLDNLQAAIKFR 63
            :::.|..|.::      |..|: ||:  ::||  ||.: ..||:      |..........:: .
Human   165 KLMECHECGKA------FSRGS-HLIQHQKIH--TGEKPFGCKE------CGKAFSRASHLVQ-H 213

  Fly    64 QRCIIAEKQNLERIECDSKDCSTDPIIYEDIDDNQIESELDESILCPEVKDLPMPSAEKVSAPTS 128
            ||....||      ..|.|||            .:......|.||...:.....|...|....|.
Human   214 QRIHTGEK------PYDCKDC------------GKAFGRTSELILHQRLHTGVKPYECKECGKTF 260

  Fly   129 LNHQKSI-----GGGTGPYVCPDCGRIINNKSNFQEHTLRHTGIKNFHCVFLNCERSFATRKELT 188
            ..|.:.|     ..|..||||.|||:.....|....|...|||.:.:.|  ..|.::|....:||
Human   261 RQHSQLILHQRTHTGEKPYVCKDCGKAFIRGSQLTVHRRIHTGARPYEC--KECGKAFRQHSQLT 323

  Fly   189 SHTRIHTGEQPYVCVYCPRRFSSSGARQEHHRRHRNERRYECDTCKKSFVSSGCLRKHKMIHVDA 253
            .|.||||||:||.|..|.:.|..|.....|.|.|..|:.|||..|.|:|.....|.:|:.:|...
Human   324 VHQRIHTGEKPYECKECGKGFIHSSEVTRHQRIHSGEKPYECKECGKAFRQHAQLTRHQRVHTGD 388

  Fly   254 RNHYCYVCQKHFKRISHLMTHLSSNIH 280
            |.:.|..|.|.|.|.|:|:.|  ..||
Human   389 RPYECKDCGKAFSRSSYLIQH--QRIH 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071	17/72 (24%)
		C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		C2H2 Zn finger	172..194	CDD:275368	7/21 (33%)
		zf-H2C2_2	186..211	CDD:290200	14/24 (58%)
		UFD2	<256..>294	CDD:227443	10/25 (40%)
		C2H2 Zn finger	258..280	CDD:275368	8/21 (38%)
ZNF565	NP_001035939.1	KRAB	6..66	CDD:214630
		C2H2 Zn finger	169..189	CDD:275368	6/26 (23%)
		COG5048	193..498	CDD:227381	74/250 (30%)
		C2H2 Zn finger	197..217	CDD:275368	5/26 (19%)
		C2H2 Zn finger	225..245	CDD:275368	6/31 (19%)
		C2H2 Zn finger	253..273	CDD:275368	4/19 (21%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		C2H2 Zn finger	309..329	CDD:275368	7/21 (33%)
		C2H2 Zn finger	337..357	CDD:275368	6/19 (32%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	8/21 (38%)
		C2H2 Zn finger	421..441	CDD:275368
		C2H2 Zn finger	449..469	CDD:275368
		C2H2 Zn finger	477..497	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960