DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6813 and ZNF660-ZNF197

DIOPT Version :9

Sequence 1:	NP_001163590.1	Gene:	CG6813 / 41396	FlyBaseID:	FBgn0037923	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001338661.1	Gene:	ZNF660-ZNF197 / 110354863	-ID:	-	Length:	1029	Species:	Homo sapiens

Alignment Length:	323	Identity:	92/323 - (28%)
Similarity:	131/323 - (40%)	Gaps:	68/323 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRICSRSDAPIDLFGPGNGHLV-RQIHSITGVELSCKKEISGQMCTTCLDNLQAAIKFRQRCIIA 69
            |..|.::      |...:..|| |:||  ||     :|......|.....:.:..|: .:|....
Human   736 CEDCGKA------FSYNSSLLVHRRIH--TG-----EKPFECSECGRAFSSNRNLIE-HKRIHSG 786

  Fly    70 EKQNLERIECDSKDCSTDPIIYEDIDDNQIESELDESILCPEVKDLPMPSAEKVSAPTS--LNHQ 132
            ||.    .|||  :|....|:.:.:..:|.....::|..|.:        ..||.:..|  :.||
Human   787 EKP----YECD--ECGKCFILKKSLIGHQRIHTREKSYKCND--------CGKVFSYRSNLIAHQ 837

  Fly   133 KSIGGGTGPYVCPDCGRIINNKSNFQEHTLRHTGIKNFHCVFLNCERSFATRKELTSHTRIHTGE 197
            : |..|..||.|.:||:......|..||...|:|.|.:.|..  |.:...:.:.|..|.||||||
Human   838 R-IHTGEKPYACSECGKGFTYNRNLIEHQRIHSGEKTYECHV--CRKVLTSSRNLMVHQRIHTGE 899

  Fly   198 QPYVCVYCPRRFSSSGARQEHHRRHRNERRYECDTCKKSFVSS----------------GC---- 242
            :||.|..|.:.||.:.....|.|.|..|:.||||.|:|||.|.                ||
Human   900 KPYKCNECGKDFSQNKNLVVHQRMHTGEKPYECDKCRKSFTSKRNLVGHQRIHTGEKPYGCNDCS 964

  Fly   243 --------LRKHKMIHVDARNHYCYVCQKHFKRISHLMTHLSSNIHKRKE----EKLTELAIE 293
                    |..|:.||.|.:...|.|.:|.|.:.|:|  ||...||..:|    :...|..||
Human   965 KVFRQRKNLTVHQKIHTDEKPCECDVSEKEFSQTSNL--HLQQKIHTIEEFSWLQNTNESKIE 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6813	NP_001163590.1	zf-AD	6..76	CDD:285071	16/70 (23%)
		C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		C2H2 Zn finger	172..194	CDD:275368	5/21 (24%)
		zf-H2C2_2	186..211	CDD:290200	13/24 (54%)
		UFD2	<256..>294	CDD:227443	14/42 (33%)
		C2H2 Zn finger	258..280	CDD:275368	8/21 (38%)
ZNF660-ZNF197	NP_001338661.1	SCAN	38..150	CDD:128708
		KRAB	216..256	CDD:307490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..290
		C2H2 Zn finger	372..392	CDD:275368
		zf-H2C2_2	384..409	CDD:316026
		C2H2 Zn finger	400..420	CDD:275368
		COG5048	424..853	CDD:227381	35/145 (24%)
		C2H2 Zn finger	428..448	CDD:275368
		C2H2 Zn finger	456..476	CDD:275368
		C2H2 Zn finger	484..504	CDD:275368
		C2H2 Zn finger	512..532	CDD:275368
		C2H2 Zn finger	540..560	CDD:275368
		C2H2 Zn finger	568..588	CDD:275368
		C2H2 Zn finger	596..616	CDD:275368
		C2H2 Zn finger	624..644	CDD:275368
		C2H2 Zn finger	652..672	CDD:275368
		C2H2 Zn finger	680..700	CDD:275368
		C2H2 Zn finger	708..728	CDD:275368
		C2H2 Zn finger	736..756	CDD:275368	6/25 (24%)
		COG5048	760..>1026	CDD:227381	82/286 (29%)
		C2H2 Zn finger	764..784	CDD:275368	3/20 (15%)
		C2H2 Zn finger	792..812	CDD:275368	5/21 (24%)
		C2H2 Zn finger	820..840	CDD:275368	6/28 (21%)
		C2H2 Zn finger	848..868	CDD:275368	6/19 (32%)
		C2H2 Zn finger	876..896	CDD:275368	5/21 (24%)
		C2H2 Zn finger	904..924	CDD:275368	6/19 (32%)
		C2H2 Zn finger	932..952	CDD:275368	7/19 (37%)
		C2H2 Zn finger	960..980	CDD:275368	3/19 (16%)
		C2H2 Zn finger	988..1008	CDD:275368	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050