DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14711 and ZNF559

DIOPT Version :9

Sequence 1:	NP_650094.1	Gene:	CG14711 / 41395	FlyBaseID:	FBgn0037922	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001189335.1	Gene:	ZNF559 / 84527	HGNCID:	28197	Length:	602	Species:	Homo sapiens

Alignment Length:	403	Identity:	105/403 - (26%)
Similarity:	160/403 - (39%)	Gaps:	109/403 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LFDDNDAQCRELVRKIEEVGSIKLVPLQNIPSMLCYSCVE--RLTSAHKFRELCQESERTF-ATN 84
            |||.|  ||.:.:.:                    :||::  |.|...|....|.:.|:.| ..:
Human   154 LFDFN--QCEKALSE--------------------HSCLKTHRRTYFRKKTCECNQCEKAFRKPS 196

  Fly    85 VVKAEMKSEPTDEVP-------------HVV----ADNIEYIYESANDFIDGVEDDIGMENIMEE 132
            :.....|::..:|:|             |:|    :.|:..:.:..              :..|:
Human   197 IFTLHKKTDIGEELPNCNQCETAFSQHLHLVCKKTSQNLHLVCKKT--------------HTQEK 247

  Fly   133 P-----LEDGVGETS------------QAYETSTVVDDLDEDDLLVPNSTDSDYQPIERCRKAKV 180
            |     .|.|:..:|            :.|.....|:.......|..:....|.:....|:..
Human   248 PYKCSDCEKGLPSSSHLRECVRIYGGERPYTHKEYVETFSHSTALFVHMQTQDGEKFYECKAC-- 310

  Fly   181 RKTRMTKRGRGRPRGASS-------GHPRSFSEERPPVQASFKSSPEVS--------STNIMCEI 230
                      |:|...||       .|.|....|......:|..||:::        ..:.:|..
Human   311 ----------GKPFTESSYLTQHLRTHSRVLPIEHKKFGKAFAFSPDLAKHIRLRTRGKHYVCNE 365

  Fly   231 CGNIYSKRAALNIHMRRHMAEKPFKCEICSKSFAGPSELNRHIRVHTGEKPFLCKYCNRSFADRS 295
            ||..::..:.||||:|.|..|||::|..|.|:|...|.|.:|.|.||||||:.||.|.::||:.|
Human   366 CGKEFTCFSKLNIHIRVHTGEKPYECNKCGKAFTDSSGLIKHRRTHTGEKPYECKECGKAFANSS 430

  Fly   296 SNIRHERTHTNERPFTCSTCGKAFSYSNVLKNHMLTHTGEKPFLCRVCNKTFSRKHQLDQHLGTM 360
            ....|.||||.|:|:.|..|||||..|:..|:||.||.|.||:.|:.|.|.|.|...|.:||.:
Human   431 HLTVHMRTHTGEKPYQCKECGKAFINSSSFKSHMQTHPGVKPYDCQQCGKAFIRSSFLIRHLRS- 494

  Fly   361 THQQTVIHHKNER 373
                    |..||
Human   495 --------HSAER 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14711	NP_650094.1	zf-AD	6..81	CDD:285071	13/59 (22%)
		C2H2 Zn finger	228..248	CDD:275368	8/19 (42%)
		zf-H2C2_2	240..264	CDD:290200	12/23 (52%)
		COG5048	249..>362	CDD:227381	53/112 (47%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		zf-H2C2_2	268..292	CDD:290200	12/23 (52%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-H2C2_2	299..321	CDD:290200	13/21 (62%)
		C2H2 Zn finger	312..332	CDD:275368	10/19 (53%)
		zf-H2C2_2	325..349	CDD:290200	12/23 (52%)
		C2H2 Zn finger	340..362	CDD:275368	8/21 (38%)
ZNF559	NP_001189335.1	KRAB	78..>118	CDD:214630
		KRAB	78..117	CDD:279668
		C2H2 Zn finger	158..177	CDD:275368	6/40 (15%)
		C2H2 Zn finger	185..240	CDD:275368	9/54 (17%)
		COG5048	212..601	CDD:227381	88/323 (27%)
		C2H2 Zn finger	213..243	CDD:275368	3/43 (7%)
		C2H2 Zn finger	251..299	CDD:275368	6/47 (13%)
		C2H2 Zn finger	307..327	CDD:275368	5/31 (16%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		zf-H2C2_2	376..399	CDD:290200	12/22 (55%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		zf-H2C2_2	404..428	CDD:290200	13/23 (57%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		zf-H2C2_2	431..454	CDD:290200	11/22 (50%)
		zf-C2H2	445..467	CDD:278523	10/21 (48%)
		C2H2 Zn finger	447..467	CDD:275368	10/19 (53%)
		C2H2 Zn finger	475..495	CDD:275368	8/28 (29%)
		zf-H2C2_2	488..512	CDD:290200	6/21 (29%)
		C2H2 Zn finger	503..523	CDD:275368
		zf-H2C2_2	515..539	CDD:290200
		C2H2 Zn finger	531..551	CDD:275368
		zf-H2C2_2	544..568	CDD:290200
		C2H2 Zn finger	559..579	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910