DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14711 and ZNF556

DIOPT Version :9

Sequence 1:	NP_650094.1	Gene:	CG14711 / 41395	FlyBaseID:	FBgn0037922	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_079243.1	Gene:	ZNF556 / 80032	HGNCID:	25669	Length:	456	Species:	Homo sapiens

Alignment Length:	201	Identity:	64/201 - (31%)
Similarity:	96/201 - (47%)	Gaps:	13/201 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 NSTDSDYQPIERCRKAKVRKTRMTKRGRGRPRGASSGHPRSFSEERPPVQASFKSSPEVSSTNIM 227
            :|....:...||......|..|..|..:|..||      |:|.:.| ......:.:...|.....
Human    91 HSVKDKHNTKERHLSRNPRVERPCKSSKGNKRG------RTFRKTR-NCNRHLRKNCCTSVRRYE 148

  Fly   228 CEICGNIYSKRAALNIHMRRHMAEKPFKCEICSKSFAGPSELNRHIRVHTGEKPFLCKYCNRSFA 292
            |..||.:::..::|..|.|.|..:|.:||:.|.|:|:.||.|..|.:.|:||||:.|:.|.::|.
Human   149 CSQCGKLFTHSSSLIRHKRAHSGQKLYKCKECGKAFSRPSYLQTHEKTHSGEKPYACQSCGKTFL 213

  Fly   293 DRSSNIRHERTHTNERPFTCSTCGKAFSYSNVLKNHMLTHTGEKPFLCRVCNKTFS-----RKHQ 352
            ...|...|.||||.|:|:.|..|||.||.....:.|::.|.|.:|:.|:.|.|.|.     |.|.
Human   214 RSHSLTEHVRTHTGEKPYECGQCGKGFSCPKSFRAHVMMHAGGRPYECKHCGKAFRCQKSFRVHM 278

  Fly   353 LDQHLG 358
            : .|.|
Human   279 I-MHAG 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14711	NP_650094.1	zf-AD	6..81	CDD:285071
		C2H2 Zn finger	228..248	CDD:275368	6/19 (32%)
		zf-H2C2_2	240..264	CDD:290200	9/23 (39%)
		COG5048	249..>362	CDD:227381	44/115 (38%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		zf-H2C2_2	268..292	CDD:290200	9/23 (39%)
		C2H2 Zn finger	284..304	CDD:275368	6/19 (32%)
		zf-H2C2_2	299..321	CDD:290200	12/21 (57%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		zf-H2C2_2	325..349	CDD:290200	8/28 (29%)
		C2H2 Zn finger	340..362	CDD:275368	8/24 (33%)
ZNF556	NP_079243.1	KRAB	<14..43	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..125		8/37 (22%)
		C2H2 Zn finger	123..139	CDD:275368	4/22 (18%)
		COG5048	<146..294	CDD:227381	51/139 (37%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		zf-H2C2_2	161..186	CDD:290200	10/24 (42%)
		zf-C2H2	175..197	CDD:278523	9/21 (43%)
		C2H2 Zn finger	177..197	CDD:275368	8/19 (42%)
		zf-H2C2_2	189..214	CDD:290200	10/24 (42%)
		C2H2 Zn finger	205..225	CDD:275368	6/19 (32%)
		zf-H2C2_2	217..242	CDD:290200	13/24 (54%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		C2H2 Zn finger	261..281	CDD:275368	6/20 (30%)
		C2H2 Zn finger	289..309	CDD:275368
		zf-H2C2_2	301..324	CDD:290200
		C2H2 Zn finger	317..337	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..365
		C2H2 Zn finger	372..392	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..406
		C2H2 Zn finger	427..447	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910