DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14711 and ZNF180

DIOPT Version :9

Sequence 1:	NP_650094.1	Gene:	CG14711 / 41395	FlyBaseID:	FBgn0037922	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_037388.3	Gene:	ZNF180 / 7733	HGNCID:	12970	Length:	692	Species:	Homo sapiens

Alignment Length:	404	Identity:	105/404 - (25%)
Similarity:	164/404 - (40%)	Gaps:	88/404 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FDDNDAQCRELVRKIEEVG----------SIKLVPLQN-IPSMLCYSCVERLTSAHKFRELCQES 77
            |....|...|.|.|.:|.|          |..::|::| ....:.::....|.:|....:...|:
Human   178 FTQRKAVIHERVCKSDETGEKSGLNSSLFSSPVIPIRNHFHKHVSHAKKWHLNAAVNSHQKINEN 242

  Fly    78 ERTFATN--------VVKAEMKSEPTDEVPHVVADNIE--------YIYESAN------DFID-- 118
            |..:..|        :...:.....|.:..:..:|.|:        :|:|..:      ||.:
Human   243 ETLYENNECGKPPQSIHLIQFTRTQTKDKSYGFSDRIQSFCHGTPLHIHEKIHGGGKTFDFKECG 307

  Fly   119 -GVEDDIGMENIMEEPLEDGVGETSQAYETSTVVDDLDEDDLLVPNSTDSDYQPIE--RCRKAKV 180
             .:...|........|.|:...:.|:...:|::..::         ..:|:.:|.|  :|.|:..
Human   308 QVLNPKISHNEQQRIPFEESQYKCSETSHSSSLTQNM---------RNNSEEKPFECNQCGKSFS 363

  Fly   181 RKTRMTKRGR-------------GRPRGASS---GHPRSFSEERPPVQASFKSSPEVSSTNIMCE 229
            ..:.:....|             |:....||   .|.|:.:.|:|                ..|.
Human   364 WSSHLVAHQRTHTGEKPYECSECGKSFSRSSHLVSHQRTHTGEKP----------------YRCN 412

  Fly   230 ICGNIYSKRAALNIHMRRHMAEKPFKCEICSKSFAGPSELNRHIRVHTGEKPFLCKYCNRSFADR 294
            .||..:|:...|.:|.|.|..|||::|..|.|||....:|..|.|.||||||:.|..|.:||...
Human   413 QCGKSFSQSYVLVVHQRTHTGEKPYECNQCGKSFRQSYKLIAHQRTHTGEKPYECNQCGKSFIQS 477

  Fly   295 SSNIRHERTHTNERPFTCSTCGKAFSYSNVLKNHMLTHTGEKPFLCRVCNKTFSRKHQLDQHLGT 359
            ...|.|:|.||.|:|:.|:.|||:||.|..|..|..||||||||.|..|.|:||...||
Human   478 YKLIAHQRIHTGEKPYECNQCGKSFSQSYKLVAHQRTHTGEKPFECNQCGKSFSWSSQL------ 536

  Fly   360 MTHQQTVIHHKNER 373
            :.||:|   |..|:
Human   537 VAHQRT---HTGEK 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14711	NP_650094.1	zf-AD	6..81	CDD:285071	14/67 (21%)
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		zf-H2C2_2	240..264	CDD:290200	11/23 (48%)
		COG5048	249..>362	CDD:227381	52/112 (46%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		zf-H2C2_2	268..292	CDD:290200	12/23 (52%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	299..321	CDD:290200	11/21 (52%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	14/23 (61%)
		C2H2 Zn finger	340..362	CDD:275368	7/21 (33%)
ZNF180	NP_037388.3	KRAB	72..133	CDD:214630
		KRAB	72..111	CDD:279668
		C2H2 Zn finger	249..267	CDD:275368	1/17 (6%)
		C2H2 Zn finger	275..295	CDD:275368	4/19 (21%)
		COG5048	332..692	CDD:227381	80/250 (32%)
		C2H2 Zn finger	355..375	CDD:275368	3/19 (16%)
		zf-H2C2_2	367..392	CDD:290200	2/24 (8%)
		C2H2 Zn finger	383..403	CDD:275368	5/19 (26%)
		zf-H2C2_2	395..420	CDD:290200	7/40 (18%)
		C2H2 Zn finger	411..431	CDD:275368	7/19 (37%)
		zf-H2C2_2	424..448	CDD:290200	12/23 (52%)
		C2H2 Zn finger	439..459	CDD:275368	8/19 (42%)
		zf-H2C2_2	455..476	CDD:290200	12/20 (60%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		zf-H2C2_2	483..504	CDD:290200	11/20 (55%)
		C2H2 Zn finger	495..515	CDD:275368	9/19 (47%)
		zf-H2C2_2	508..531	CDD:290200	13/22 (59%)
		C2H2 Zn finger	523..543	CDD:275368	10/28 (36%)
		zf-H2C2_2	536..560	CDD:290200	6/21 (29%)
		C2H2 Zn finger	551..571	CDD:275368
		zf-H2C2_2	563..588	CDD:290200
		C2H2 Zn finger	579..599	CDD:275368
		zf-H2C2_2	592..616	CDD:290200
		C2H2 Zn finger	607..627	CDD:275368
		zf-H2C2_2	620..643	CDD:290200
		C2H2 Zn finger	635..655	CDD:275368
		zf-H2C2_2	648..670	CDD:290200
		C2H2 Zn finger	663..683	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910