DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14711 and ZNF69

DIOPT Version :9

Sequence 1:	NP_650094.1	Gene:	CG14711 / 41395	FlyBaseID:	FBgn0037922	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	XP_006722936.1	Gene:	ZNF69 / 7620	HGNCID:	13138	Length:	569	Species:	Homo sapiens

Alignment Length:	174	Identity:	67/174 - (38%)
Similarity:	88/174 - (50%)	Gaps:	19/174 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 HPRSFSEERPPVQASFKSSPEVSSTNIMCEICGNIYSKRAALNIHMRRHMAEKPFKCEICSKSFA 264
            |.|:.|.::|                ..|..||...|...:...|:|.|..|:|::|:||.|.|.
Human   325 HERTHSRKKP----------------YECTQCGKALSSLTSFQTHIRMHSGERPYECKICGKGFC 373

  Fly   265 GPSELNRHIRVHTGEKPFLCKYCNRSFADRSSNIRHERTHTNERPFTCSTCGKAFSYSNVLKNHM 329
            ..:...||.:.|:||||:.||.|.::|...||...|||.||.|:|:.|..|||||..|:.|:.|.
Human   374 SANSFQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHG 438

  Fly   330 LTHTGEKPFLCRVCNKTFSRKHQLDQHLGTMTHQQTVIHHKNER 373
            .|||||||:.|:.|.|.|.....|..|..|.||   |..|..||
Human   439 RTHTGEKPYECQECGKAFRSMKNLQSHERTQTH---VRIHSGER 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14711	NP_650094.1	zf-AD	6..81	CDD:285071
		C2H2 Zn finger	228..248	CDD:275368	6/19 (32%)
		zf-H2C2_2	240..264	CDD:290200	9/23 (39%)
		COG5048	249..>362	CDD:227381	50/112 (45%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..292	CDD:290200	10/23 (43%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-H2C2_2	299..321	CDD:290200	13/21 (62%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	13/23 (57%)
		C2H2 Zn finger	340..362	CDD:275368	7/21 (33%)
ZNF69	XP_006722936.1	KRAB	27..>67	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	169..189	CDD:275368
		C2H2 Zn finger	197..217	CDD:275368
		COG5048	222..>540	CDD:227381	67/174 (39%)
		C2H2 Zn finger	225..245	CDD:275368
		zf-H2C2_2	241..262	CDD:290200
		C2H2 Zn finger	253..273	CDD:275368
		zf-H2C2_2	266..290	CDD:290200
		C2H2 Zn finger	281..301	CDD:275368
		zf-H2C2_2	295..318	CDD:290200
		C2H2 Zn finger	309..329	CDD:275368	2/3 (67%)
		C2H2 Zn finger	337..357	CDD:275368	6/19 (32%)
		zf-H2C2_2	349..372	CDD:290200	9/22 (41%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		zf-H2C2_2	377..400	CDD:290200	10/22 (45%)
		C2H2 Zn finger	393..413	CDD:275368	9/19 (47%)
		zf-H2C2_2	405..430	CDD:290200	14/24 (58%)
		C2H2 Zn finger	421..441	CDD:275368	9/19 (47%)
		C2H2 Zn finger	449..468	CDD:275368	6/18 (33%)
		C2H2 Zn finger	483..503	CDD:275368
		zf-H2C2_2	495..520	CDD:290200
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	523..546	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910