DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14711 and ZFP37

DIOPT Version :9

Sequence 1:	NP_650094.1	Gene:	CG14711 / 41395	FlyBaseID:	FBgn0037922	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001269444.1	Gene:	ZFP37 / 7539	HGNCID:	12863	Length:	645	Species:	Homo sapiens

Alignment Length:	191	Identity:	75/191 - (39%)
Similarity:	95/191 - (49%)	Gaps:	31/191 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 HPRSFSEERPPVQASFKSSPEVSSTNIMCEICGNIYSKRAALNIHMRRHMAEKPFKCEICSKSFA 264
            |.|:.:.|:|                ..|..||..:..:.||..|:|.|..|||::|..|.|:|.
Human   354 HQRTHTGEKP----------------YECIQCGKAHGHKHALTDHLRIHTGEKPYECAECGKTFR 402

  Fly   265 GPSELNRHIRVHTGEKPFLCKYCNRSFADRSSNIRHERTHTNERPFTCSTCGKAFSYSNVLKNHM 329
            ..|.|.:|:|.||||||:.||.|.:||...||...|.||||.|.|:.|:.|||||.||:.|..||
Human   403 HSSNLIQHVRSHTGEKPYECKECGKSFRYNSSLTEHVRTHTGEIPYECNECGKAFKYSSSLTKHM 467

  Fly   330 LTHTGEKPFLCRVCNKTFSRKHQLDQHLGTMT---------------HQQTVIHHKNERTG 375
            ..|||||||.|..|.|.||:|..|..|..|.|               |..::.:|....||
Human   468 RIHTGEKPFECNECGKAFSKKSHLIIHQRTHTKEKPYKCNECGKAFGHSSSLTYHMRTHTG 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14711	NP_650094.1	zf-AD	6..81	CDD:285071
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		zf-H2C2_2	240..264	CDD:290200	11/23 (48%)
		COG5048	249..>362	CDD:227381	59/127 (46%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		zf-H2C2_2	268..292	CDD:290200	13/23 (57%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-H2C2_2	299..321	CDD:290200	13/21 (62%)
		C2H2 Zn finger	312..332	CDD:275368	11/19 (58%)
		zf-H2C2_2	325..349	CDD:290200	14/23 (61%)
		C2H2 Zn finger	340..362	CDD:275368	10/36 (28%)
ZFP37	NP_001269444.1	KRAB	47..106	CDD:214630
		KRAB	47..86	CDD:279668
		COG5048	288..>633	CDD:227381	75/191 (39%)
		C2H2 Zn finger	310..330	CDD:275368
		C2H2 Zn finger	338..358	CDD:275368	2/3 (67%)
		zf-H2C2_2	350..372	CDD:290200	7/33 (21%)
		C2H2 Zn finger	366..386	CDD:275368	7/19 (37%)
		zf-H2C2_2	378..403	CDD:290200	12/24 (50%)
		C2H2 Zn finger	394..414	CDD:275368	8/19 (42%)
		zf-H2C2_2	406..431	CDD:290200	14/24 (58%)
		C2H2 Zn finger	422..442	CDD:275368	9/19 (47%)
		zf-H2C2_2	434..459	CDD:290200	14/24 (58%)
		zf-C2H2	448..470	CDD:278523	11/21 (52%)
		C2H2 Zn finger	450..470	CDD:275368	11/19 (58%)
		zf-H2C2_2	462..486	CDD:290200	13/23 (57%)
		C2H2 Zn finger	478..498	CDD:275368	8/19 (42%)
		zf-H2C2_2	490..513	CDD:290200	4/22 (18%)
		C2H2 Zn finger	506..526	CDD:275368	2/19 (11%)
		zf-H2C2_2	518..543	CDD:290200	3/11 (27%)
		C2H2 Zn finger	534..554	CDD:275368
		zf-H2C2_2	547..571	CDD:290200
		C2H2 Zn finger	562..582	CDD:275368
		zf-H2C2_2	574..598	CDD:290200
		C2H2 Zn finger	590..610	CDD:275368
		zf-H2C2_2	603..627	CDD:290200
		C2H2 Zn finger	618..638	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910