DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14711 and Zif

DIOPT Version :9

Sequence 1:	NP_650094.1	Gene:	CG14711 / 41395	FlyBaseID:	FBgn0037922	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	102/387 - (26%)
Similarity:	168/387 - (43%)	Gaps:	58/387 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CRICLTEDINSEAMAPLFDDNDAQCRELVRKIEEVGSIKLVPLQNIPSMLCYSCVERLTSAHKFR 71
            ||:||.:....:.:..:.::.:....|::.::..|....|...::||..:|.||...|..|::||
  Fly    10 CRVCLAQSERLQRLDEIREEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELNMAYQFR 74

  Fly    72 E-----------------LCQESERTFATNVVKAEMKSEPTDEVPHVVADNIEYIYESANDFIDG 119
            |                 |..||:    ..::|.|..|:..       .|...||.|......:.
  Fly    75 EKALRKQMEIEEYCRELGLLDESD----VMMIKEEDGSQQQ-------CDEEMYILEETTTGEEE 128

  Fly   120 VEDDIGMENIMEEPLEDG---VGETSQAYETS-TVVDDLDEDDLLVPN-----STDSDYQPIERC 175
            .:::.|.|..:|....|.   :|:|.:..|.: |:..:.|:.::::.:     .|.|....::..
  Fly   129 HQEEKGHEEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQQLALQEA 193

  Fly   176 RKAKVRKTRMTKRGRGRPRGASSGHPRSFSEERPPVQASFKSSPEVSSTNIMCEICGNIYSKRAA 240
            .||.::    .:|||.| ||.:                |..:|........:|::|||.|.||..
  Fly   194 AKASLK----ARRGRVR-RGLN----------------SLTTSDGTEKGGYICDVCGNFYEKRGR 237

  Fly   241 LNIHMRRHMAEKPFKCEICSKSFAGPSELNRHIRVHTGEKPFLCKYCNRSFADRSSNIRHERTHT 305
            :..|.|||.....:.||:|...|....:|.:|:..|||.||:.|.:|:|.|...|....||..|.
  Fly   238 MMEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHR 302

  Fly   306 NERPFTCSTCGKAFSYSNVLKNHMLTHTGEKPFLCRVCNKTFSRKHQLDQHLGTMTHQQTVI 367
            ..:|:.|..|.|||:|::.|..|.|.|:..|.:.|..|||.|...|.:.||..|..||..|:
  Fly   303 GIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNKDFRLLHHMRQHEETKLHQNAVM 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14711	NP_650094.1	zf-AD	6..81	CDD:285071	20/90 (22%)
		C2H2 Zn finger	228..248	CDD:275368	9/19 (47%)
		zf-H2C2_2	240..264	CDD:290200	7/23 (30%)
		COG5048	249..>362	CDD:227381	40/112 (36%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..292	CDD:290200	10/23 (43%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	299..321	CDD:290200	9/21 (43%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	10/23 (43%)
		C2H2 Zn finger	340..362	CDD:275368	9/21 (43%)
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	17/76 (22%)
		C2H2 Zn finger	225..245	CDD:275368	9/19 (47%)
		COG5048	<250..369	CDD:227381	43/115 (37%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		zf-H2C2_2	266..288	CDD:290200	10/21 (48%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	294..318	CDD:290200	9/23 (39%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		C2H2 Zn finger	337..353	CDD:275368	6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3C1GA
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860