DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14711 and ZNF596

DIOPT Version :9

Sequence 1:	NP_650094.1	Gene:	CG14711 / 41395	FlyBaseID:	FBgn0037922	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001035880.1	Gene:	ZNF596 / 169270	HGNCID:	27268	Length:	504	Species:	Homo sapiens

Alignment Length:	382	Identity:	108/382 - (28%)
Similarity:	162/382 - (42%)	Gaps:	67/382 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TEDINSEAMAPLFDD--NDAQCRELVRKIEEVGSIKLVPLQNIPSMLCYSCVE----RLTSAHKF 70
            |:...|:....:|.|  :..|.:|:..|.:..||          .:..|:.::    |..|....
Human   136 TKHFVSKKFGKIFSDWLSFNQHKEIHTKCKSYGS----------HLFDYAFIQNSALRPHSVTHT 190

  Fly    71 REL---CQESERTFATNVVKAEMKSEPTDEVPHVVADNIEYIYESANDFIDGVEDDIGMENIMEE 132
            ||:   |:...:||:.|......:...|.|.|| ........:...:|.........|     |:
Human   191 REITLECRVCGKTFSKNSNLRRHEMIHTGEKPH-GCHLCGKAFTHCSDLRKHERTHTG-----EK 249

  Fly   133 PLEDGVGETSQAYETSTVVDDLDEDDLLVPNSTDSDYQPIERCRKA-----KVRKTRMTKRGRGR 192
            |.  |.....:|:..|:   :|...:::   .|....|....|.||     .:||...|..| .:
Human   250 PY--GCHLCGKAFSKSS---NLRRHEMI---HTREKAQICHLCGKAFTHCSDLRKHERTHLG-DK 305

  Fly   193 PRGA------------SSGHPRSFSEERPPVQASFKSSPEVSSTNIMCEICGNIYSKRAALNIHM 245
            |.|.            ...|.|:.:.|:|                ..|.:||..:|..:.|..|.
Human   306 PYGCLLCGKAFSKCSYLRQHERTHNGEKP----------------YECHLCGKAFSHCSHLRQHE 354

  Fly   246 RRHMAEKPFKCEICSKSFAGPSELNRHIRVHTGEKPFLCKYCNRSFADRSSNIRHERTHTNERPF 310
            |.|..|||..|.:|.|:|...|.|.||.|:||||||:.|..|.::|.:.|...|||||||.|:|:
Human   355 RSHNGEKPHGCHLCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLRRHERTHTGEKPY 419

  Fly   311 TCSTCGKAFSYSNVLKNHMLTHTGEKPFLCRVCNKTFSRKHQLDQHLGTMTHQQTVI 367
            .|..|||||::|:||:.|..|||||||:.|.:|.|.|:|.:....|....|.::..:
Human   420 ECHLCGKAFNHSSVLRRHERTHTGEKPYECNICGKAFNRSYNFRLHRRVHTGEKPYV 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14711	NP_650094.1	zf-AD	6..81	CDD:285071	15/77 (19%)
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		zf-H2C2_2	240..264	CDD:290200	10/23 (43%)
		COG5048	249..>362	CDD:227381	54/112 (48%)
		C2H2 Zn finger	256..276	CDD:275368	9/19 (47%)
		zf-H2C2_2	268..292	CDD:290200	12/23 (52%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-H2C2_2	299..321	CDD:290200	15/21 (71%)
		C2H2 Zn finger	312..332	CDD:275368	10/19 (53%)
		zf-H2C2_2	325..349	CDD:290200	13/23 (57%)
		C2H2 Zn finger	340..362	CDD:275368	6/21 (29%)
ZNF596	NP_001035880.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	197..217	CDD:275368	4/19 (21%)
		C2H2 Zn finger	225..245	CDD:275368	1/19 (5%)
		C2H2 Zn finger	253..273	CDD:275368	3/25 (12%)
		C2H2 Zn finger	281..301	CDD:275368	5/19 (26%)
		C2H2 Zn finger	309..329	CDD:275368	2/19 (11%)
		zf-H2C2_2	321..346	CDD:290200	7/40 (18%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		COG5048	<361..502	CDD:227381	54/116 (47%)
		C2H2 Zn finger	365..385	CDD:275368	9/19 (47%)
		zf-H2C2_2	378..401	CDD:290200	12/22 (55%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		zf-H2C2_2	405..430	CDD:290200	15/24 (63%)
		C2H2 Zn finger	421..441	CDD:275368	10/19 (53%)
		zf-H2C2_2	434..458	CDD:290200	13/23 (57%)
		C2H2 Zn finger	449..469	CDD:275368	6/19 (32%)
		zf-H2C2_2	461..485	CDD:290200	2/16 (13%)
		C2H2 Zn finger	477..497	CDD:275368	108/382 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910