DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14711 and ZNF891

DIOPT Version :9

Sequence 1:NP_650094.1 Gene:CG14711 / 41395 FlyBaseID:FBgn0037922 Length:377 Species:Drosophila melanogaster
Sequence 2:NP_001264220.1 Gene:ZNF891 / 101060200 HGNCID:38709 Length:544 Species:Homo sapiens


Alignment Length:479 Identity:108/479 - (22%)
Similarity:193/479 - (40%) Gaps:125/479 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 EYMLCRICLTEDINSE-----------AMAPLFDDNDAQCR---ELVRKI---EEVGSIKLVPL- 49
            ||.|.|:.:...::.|           |:.|   |...|.:   ..|:||   |...::|::.| 
Human    83 EYQLYRLTVISPLDQEEIRNMKKRIPQAICP---DQKIQPKTKESTVQKILWEEPSNAVKMIKLT 144

  Fly    50 -QNIPSML--CYSCVERLTSAHK-----FRELCQESERTFATNVVKAEMKSEPTDEVPHVVADNI 106
             .|..|.|  .:.| .::...||     :|::....::|....:.:...:.|...::...:..: 
Human   145 MHNWSSTLREDWEC-HKIRKQHKIPGGHWRQMIYAPKKTVPQELFRDYHELEENSKLGSKLIFS- 207

  Fly   107 EYIYESANDFIDGVEDDIGM---ENIMEEPLEDGVGE-TSQAYETSTVVDDLDEDDLL------- 160
            :.|:.|.:  ......:||.   .:|:...:::.:.| ..:::|..|.:.....:..:       
Human   208 QSIFTSKH--CQKCYSEIGCLKHNSIINNYVKNSISEKLYESHECDTTLWHFQRNQTVQKEYTYS 270

  Fly   161 ------------VPNSTDSDYQPIERCRKAKV--RKTRMTKRGRGRPRGASSGHPRSFSEERPPV 211
                        |||:........| |.|.:.  .::.:.|:|            ::.:|::...
Human   271 KHGMHFTHNMFPVPNNLHMAQNACE-CNKDETLCHQSSLKKQG------------QTHTEKKHEC 322

  Fly   212 QASFKSSPEVSSTNIM-----------CEICGNIYSKRAALNIHMRRHMAEKPFKCEICSKSFAG 265
            ....|:...:|:..:.           |:.||.:::..:.|..|:|.|..|||::|..|.|:|:.
Human   323 NQCGKAFKRISNLTLYKKSHMGEKQYECKECGKVFNDSSTLRRHVRTHTGEKPYECNQCGKAFSQ 387

  Fly   266 PSELNRHIRVHTGEKPFLCKYCNRSFADRSSNIRHERTHTNERPFTCSTCGKAFSYSNVLK---- 326
            .:.|..|:|.||||||:.|..|.:||...|..|.|:|.||.|:.:.||.|||||:.|:.||    
Human   388 KTSLKAHMRTHTGEKPYECNQCGKSFGTSSYLIVHKRIHTGEKLYECSECGKAFNTSSHLKVHKK 452

  Fly   327 ------------------------NHMLTHTGEKPFLCRVCNKTFSRKHQLDQHLGTMTHQQ--- 364
                                    .|:.|||||||:.|:.|.|.||....|.:|:...|.::   
Human   453 IHTGENVYECSDCGKVFSGVSSLRMHIRTHTGEKPYECKECRKAFSVSSSLRRHVRIHTGEKPYE 517

  Fly   365 ------------TVIHHKNERTGR 376
                        ::|.||...|.|
Human   518 CIQCGKAFSQSSSLIIHKRIHTER 541

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14711NP_650094.1 zf-AD 6..81 CDD:285071 20/100 (20%)
C2H2 Zn finger 228..248 CDD:275368 6/19 (32%)
zf-H2C2_2 240..264 CDD:290200 10/23 (43%)
COG5048 249..>362 CDD:227381 52/140 (37%)
C2H2 Zn finger 256..276 CDD:275368 7/19 (37%)
zf-H2C2_2 268..292 CDD:290200 12/23 (52%)
C2H2 Zn finger 284..304 CDD:275368 8/19 (42%)
zf-H2C2_2 299..321 CDD:290200 12/21 (57%)
C2H2 Zn finger 312..332 CDD:275368 11/47 (23%)
zf-H2C2_2 325..349 CDD:290200 14/51 (27%)
C2H2 Zn finger 340..362 CDD:275368 7/21 (33%)
ZNF891NP_001264220.1 KRAB 43..99 CDD:214630 4/15 (27%)
KRAB 43..82 CDD:279668
COG5048 <272..544 CDD:227381 76/283 (27%)
C2H2 Zn finger 295..315 CDD:275368 5/32 (16%)
C2H2 Zn finger 322..342 CDD:275368 2/19 (11%)
zf-C2H2 348..370 CDD:278523 6/21 (29%)
C2H2 Zn finger 350..370 CDD:275368 6/19 (32%)
zf-H2C2_2 363..387 CDD:290200 11/23 (48%)
C2H2 Zn finger 378..398 CDD:275368 7/19 (37%)
zf-H2C2_2 390..415 CDD:290200 13/24 (54%)
C2H2 Zn finger 406..426 CDD:275368 8/19 (42%)
zf-H2C2_2 418..443 CDD:290200 13/24 (54%)
C2H2 Zn finger 434..454 CDD:275368 10/19 (53%)
zf-H2C2_2 446..470 CDD:290200 2/23 (9%)
C2H2 Zn finger 462..482 CDD:275368 1/19 (5%)
zf-H2C2_2 474..498 CDD:290200 11/23 (48%)
C2H2 Zn finger 490..510 CDD:275368 7/19 (37%)
zf-H2C2_2 502..527 CDD:290200 3/24 (13%)
C2H2 Zn finger 518..538 CDD:275368 3/19 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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