DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6808 and ZNF559

DIOPT Version :9

Sequence 1:	NP_001247055.1	Gene:	CG6808 / 41394	FlyBaseID:	FBgn0037921	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001189335.1	Gene:	ZNF559 / 84527	HGNCID:	28197	Length:	602	Species:	Homo sapiens

Alignment Length:	371	Identity:	95/371 - (25%)
Similarity:	142/371 - (38%)	Gaps:	81/371 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CRTCRKKGTQSTLQSLFESNAHKLLISYAGTSVKPDDG--LPDQICTVCLMQLEEVDRFLSACKQ 72
            |..|.|...:.::.:|     ||          |.|.|  ||:  |..|.....:  .....||:
Human   185 CNQCEKAFRKPSIFTL-----HK----------KTDIGEELPN--CNQCETAFSQ--HLHLVCKK 230

  Fly    73 SDAHLRSLVRQTLSSASAFETLEDKDQLEQKKRARK-QNISGRLIEENPINFKTQENALETTKDD 136
            :..:|..:.::|.:....::..:.:..|......|: ..|.|   .|.|.   |.:..:||
Human   231 TSQNLHLVCKKTHTQEKPYKCSDCEKGLPSSSHLRECVRIYG---GERPY---THKEYVET---- 285

  Fly   137 EILPINKFSSDFVFDLNVNAENEKDIHQ-----EDYTISDMDLDREISDQNYSETYSQESSAATD 196
                   ||......:::..::.:..::     :.:|                     |||..|.
Human   286 -------FSHSTALFVHMQTQDGEKFYECKACGKPFT---------------------ESSYLTQ 322

  Fly   197 SIQETSEDYHNLEPSADYVIDLGVACEPD------------KYRCKICSNTYRCLSQLNAHSQVH 249
            .::..|    .:.|..........|..||            .|.|..|...:.|.|:||.|.:||
Human   323 HLRTHS----RVLPIEHKKFGKAFAFSPDLAKHIRLRTRGKHYVCNECGKEFTCFSKLNIHIRVH 383

  Fly   250 RKEKDHQCEVCQKTFRAACNLKTHMRTHTGEKPYQCCYCSRRFADNSTHRKHERLHTNERPYACN 314
            ..||.::|..|.|.|..:..|..|.|||||||||:|..|.:.||::|....|.|.||.|:||.|.
Human   384 TGEKPYECNKCGKAFTDSSGLIKHRRTHTGEKPYECKECGKAFANSSHLTVHMRTHTGEKPYQCK 448

  Fly   315 ICGKTFSLSSSRNAHYYLHSSEKSHKCLMCKKEFRLKHQLTAHEKS 360
            .|||.|..|||..:|...|...|.:.|..|.|.|.....|..|.:|
Human   449 ECGKAFINSSSFKSHMQTHPGVKPYDCQQCGKAFIRSSFLIRHLRS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6808	NP_001247055.1	zf-AD	9..79	CDD:214871	16/70 (23%)
		C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		zf-C2H2	255..277	CDD:278523	7/21 (33%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..293	CDD:290200	13/23 (57%)
		C2H2 Zn finger	285..305	CDD:275368	7/19 (37%)
		zf-H2C2_2	299..321	CDD:290200	11/21 (52%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		C2H2 Zn finger	341..359	CDD:275368	6/17 (35%)
ZNF559	NP_001189335.1	KRAB	78..>118	CDD:214630
		KRAB	78..117	CDD:279668
		C2H2 Zn finger	158..177	CDD:275368
		C2H2 Zn finger	185..240	CDD:275368	16/73 (22%)
		COG5048	212..601	CDD:227381	84/329 (26%)
		C2H2 Zn finger	213..243	CDD:275368	5/31 (16%)
		C2H2 Zn finger	251..299	CDD:275368	11/64 (17%)
		C2H2 Zn finger	307..327	CDD:275368	5/40 (13%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		zf-H2C2_2	376..399	CDD:290200	10/22 (45%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	404..428	CDD:290200	14/23 (61%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		zf-H2C2_2	431..454	CDD:290200	11/22 (50%)
		zf-C2H2	445..467	CDD:278523	10/21 (48%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	7/20 (35%)
		zf-H2C2_2	488..512	CDD:290200	3/7 (43%)
		C2H2 Zn finger	503..523	CDD:275368
		zf-H2C2_2	515..539	CDD:290200
		C2H2 Zn finger	531..551	CDD:275368
		zf-H2C2_2	544..568	CDD:290200
		C2H2 Zn finger	559..579	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910