Protein Alignment Zaf1 and ZNF224

DIOPT Version :10

• Sequence 1: NP_731602.1
• Gene: Zaf1 / 41394
• FlyBaseID: FBgn0037921
• Length: 375
• Species: Drosophila melanogaster
• Sequence 2: NP_037530.2
• Gene: ZNF224 / 7767
• HGNCID: 13017
• Length: 707
• Species: Homo sapiens
• Alignment Length: 233
• Identity: 72/233 - (30%)
• Similarity: 109/233 - (46%)
• Gaps: 22/233 - (9%)

  Fly   143 KFSSDFV--FDLNVNA---ENEKDIH-QEDYTISDMDLDREISDQN-YSETYSQESSAATDSIQE 200
            |.:||..  .||.:|:   ..|.|.. |.:..:|.:...::.|..| |..::|..|.........
Human   106 KIASDLTRSQDLMINSSQFSKEGDFPCQTEAGLSVIHTRQKSSQGNGYKPSFSDVSHFDFHQQLH 170

  Fly   201 TSEDYHNLEPSAD---YV--------IDLGVACEPDKYRCKICSNTYRCLSQLNAHSQVHRKEKD 254
            :.|..|..:....   |:        :.:|..|    |:|.:|...:...|.|..|.:||..||.
Human   171 SGEKSHTCDECGKNFCYISALRIHQRVHMGEKC----YKCDVCGKEFSQSSHLQTHQRVHTGEKP 231

  Fly   255 HQCEVCQKTFRAACNLKTHMRTHTGEKPYQCCYCSRRFADNSTHRKHERLHTNERPYACNICGKT 319
            .:|..|.|.|.....|..|.:.|||||||.|..|.:.|..:|..::|:|:||.|:|:.|:||||:
Human   232 FKCVECGKGFSRRSALNVHHKLHTGEKPYNCEECGKAFIHDSQLQEHQRIHTGEKPFKCDICGKS 296

  Fly   320 FSLSSSRNAHYYLHSSEKSHKCLMCKKEFRLKHQLTAH 357
            |...|..|.|..:|::||..:|..|.|.||.:..|.:|
Human   297 FCGRSRLNRHSMVHTAEKPFRCDTCDKSFRQRSALNSH 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zaf1	NP_731602.1	zf-AD	9..79	CDD:214871
		SFP1	<161..320	CDD:227516	51/171 (30%)
		C2H2 Zn finger	229..249	CDD:275368	5/19 (26%)
		C2H2 Zn finger	257..277	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..293	CDD:463886	11/23 (48%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		C2H2 Zn finger	341..359	CDD:275368	7/17 (41%)
ZNF224	NP_037530.2	KRAB	8..67	CDD:214630
		C2H2 Zn finger	178..198	CDD:275368	1/19 (5%)
		COG5048	202..641	CDD:227381	53/137 (39%)
		C2H2 Zn finger	206..226	CDD:275368	5/19 (26%)
		C2H2 Zn finger	234..254	CDD:275368	6/19 (32%)
		C2H2 Zn finger	262..282	CDD:275368	6/19 (32%)
		C2H2 Zn finger	290..310	CDD:275368	9/19 (47%)
		C2H2 Zn finger	318..338	CDD:275368	7/17 (41%)
		C2H2 Zn finger	346..366	CDD:275368
		C2H2 Zn finger	374..394	CDD:275368
		C2H2 Zn finger	402..422	CDD:275368
		C2H2 Zn finger	430..450	CDD:275368
		C2H2 Zn finger	458..478	CDD:275368
		C2H2 Zn finger	486..506	CDD:275368
		C2H2 Zn finger	514..534	CDD:275368
		C2H2 Zn finger	542..562	CDD:275368
		C2H2 Zn finger	570..590	CDD:275368
		C2H2 Zn finger	598..618	CDD:275368
		C2H2 Zn finger	654..674	CDD:275368
		C2H2 Zn finger	682..702	CDD:275368