DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6808 and ZNF180

DIOPT Version :9

Sequence 1:	NP_001247055.1	Gene:	CG6808 / 41394	FlyBaseID:	FBgn0037921	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_037388.3	Gene:	ZNF180 / 7733	HGNCID:	12970	Length:	692	Species:	Homo sapiens

Alignment Length:	474	Identity:	113/474 - (23%)
Similarity:	179/474 - (37%)	Gaps:	179/474 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IKWSMCRTCRKKGTQSTLQSLFESNAHKLLISYAGTSVKPDDGLPDQICTVCLMQLEEVDRFLSA 69
            :.|.:.....||.:.|. |.:|:.              :|.:|       |.:.:....|.:||:
Human   109 VSWDLATAVGKKDSTSK-QRIFDE--------------EPANG-------VKIERFTRDDPWLSS 151

  Fly    70 CKQSDAHLRSLVRQTLSSASAFETLEDKDQLEQKKRARKQNISGRLIEENPINFKTQENAL---E 131
            |::.|                    :.|||||  |:..||.|   |::|  :.| ||..|:   .
Human   152 CEEVD--------------------DCKDQLE--KQQEKQEI---LLQE--VAF-TQRKAVIHER 188

  Fly   132 TTKDDE---------------ILPINKFSSDFV-----FDLN--VNA-----ENE---------- 159
            ..|.||               ::||.......|     :.||  ||:     |||
Human   189 VCKSDETGEKSGLNSSLFSSPVIPIRNHFHKHVSHAKKWHLNAAVNSHQKINENETLYENNECGK 253

  Fly   160 ---------------KD-------------------IHQE--------DYTISDMDLDREIS--- 179
                           ||                   ||::        |:......|:.:||
Human   254 PPQSIHLIQFTRTQTKDKSYGFSDRIQSFCHGTPLHIHEKIHGGGKTFDFKECGQVLNPKISHNE 318

  Fly   180 -------DQNYSETYSQESSAATDSIQETSEDYHNLEPSADYVIDLGVACEPDKYRCKICSNTYR 237
                   :..|..:.:..||:.|.:::..||:                  :|  :.|..|..::.
Human   319 QQRIPFEESQYKCSETSHSSSLTQNMRNNSEE------------------KP--FECNQCGKSFS 363

  Fly   238 CLSQLNAHSQVHRKEKDHQCEVCQKTFRAACNLKTHMRTHTGEKPYQCCYCSRRFADNSTHRKHE 302
            ..|.|.||.:.|..||.::|..|.|:|..:.:|.:|.|||||||||:|..|.:.|:.:.....|:
Human   364 WSSHLVAHQRTHTGEKPYECSECGKSFSRSSHLVSHQRTHTGEKPYRCNQCGKSFSQSYVLVVHQ 428

  Fly   303 RLHTNERPYACNICGKTFSLSSSRNAHYYLHSSEKSHKCLMCKKEFRLKHQLTAHEK-------- 359
            |.||.|:||.||.|||:|..|....||...|:.||.::|..|.|.|...::|.||::
Human   429 RTHTGEKPYECNQCGKSFRQSYKLIAHQRTHTGEKPYECNQCGKSFIQSYKLIAHQRIHTGEKPY 493

  Fly   360 ---------SLAHRLIAKE 369
                     |.:::|:|.:
Human   494 ECNQCGKSFSQSYKLVAHQ 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6808	NP_001247055.1	zf-AD	9..79	CDD:214871	13/69 (19%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		zf-C2H2	255..277	CDD:278523	7/21 (33%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..293	CDD:290200	13/23 (57%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		zf-H2C2_2	299..321	CDD:290200	12/21 (57%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		C2H2 Zn finger	341..359	CDD:275368	7/17 (41%)
ZNF180	NP_037388.3	KRAB	72..133	CDD:214630	6/38 (16%)
		KRAB	72..111	CDD:279668	0/1 (0%)
		C2H2 Zn finger	249..267	CDD:275368	0/17 (0%)
		C2H2 Zn finger	275..295	CDD:275368	2/19 (11%)
		COG5048	332..692	CDD:227381	62/201 (31%)
		C2H2 Zn finger	355..375	CDD:275368	6/19 (32%)
		zf-H2C2_2	367..392	CDD:290200	10/24 (42%)
		C2H2 Zn finger	383..403	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..420	CDD:290200	14/24 (58%)
		C2H2 Zn finger	411..431	CDD:275368	5/19 (26%)
		zf-H2C2_2	424..448	CDD:290200	13/23 (57%)
		C2H2 Zn finger	439..459	CDD:275368	9/19 (47%)
		zf-H2C2_2	455..476	CDD:290200	8/20 (40%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		zf-H2C2_2	483..504	CDD:290200	1/20 (5%)
		C2H2 Zn finger	495..515	CDD:275368	3/18 (17%)
		zf-H2C2_2	508..531	CDD:290200	2/5 (40%)
		C2H2 Zn finger	523..543	CDD:275368
		zf-H2C2_2	536..560	CDD:290200
		C2H2 Zn finger	551..571	CDD:275368
		zf-H2C2_2	563..588	CDD:290200
		C2H2 Zn finger	579..599	CDD:275368
		zf-H2C2_2	592..616	CDD:290200
		C2H2 Zn finger	607..627	CDD:275368
		zf-H2C2_2	620..643	CDD:290200
		C2H2 Zn finger	635..655	CDD:275368
		zf-H2C2_2	648..670	CDD:290200
		C2H2 Zn finger	663..683	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910