DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6808 and ZNF177

DIOPT Version :9

Sequence 1:	NP_001247055.1	Gene:	CG6808 / 41394	FlyBaseID:	FBgn0037921	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001166122.1	Gene:	ZNF177 / 7730	HGNCID:	12966	Length:	481	Species:	Homo sapiens

Alignment Length:	305	Identity:	93/305 - (30%)
Similarity:	134/305 - (43%)	Gaps:	43/305 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 SLVRQTLSSASAFETLEDKDQLEQKKRARKQNISGRLIEENPINFKTQEN-------ALETT--- 133
            |.:|..:|.....:|||..|    .::|..|..|.|.....|...|.||.       :|.::
Human   161 STLRSHVSIHIGEKTLEFTD----CRKAFNQESSLRKHLRTPTGQKFQEYEQCDMSFSLHSSCSV 221

  Fly   134 --------KDDEILPINKFSSDFVFDLNVNAENEKDIHQEDYTISDMDLDREISDQNYSETYSQE 190
                    |.||.....|.|...|.....:.|...:.::.:.|.:|     .:|.||...|:|.|
Human   222 REQIPTGEKGDECSDYGKISPLSVHTKTGSVEEGLECNEHEKTFTD-----PLSLQNCVRTHSGE 281

  Fly   191 -----SSAATDSIQETSEDYHNLEPSADYVIDLGVACEPDKYRCKICSNTYRCLSQLNAHSQVHR 250
                 |......|.::|...|....:.:         :|  |.|..|..::...|.||.|.:.|.
Human   282 MPYECSDCGKAFIFQSSLKKHMRSHTGE---------KP--YECDHCGKSFSQSSHLNVHKRTHT 335

  Fly   251 KEKDHQCEVCQKTFRAACNLKTHMRTHTGEKPYQCCYCSRRFADNSTHRKHERLHTNERPYACNI 315
            .||.:.|:.|.|.|....:|:.|:|||||||||:|..|.:.|.|.|:.:||.|.||.|:||.||.
Human   336 GEKPYDCKECGKAFTVPSSLQKHVRTHTGEKPYECSDCGKAFIDQSSLKKHTRSHTGEKPYECNQ 400

  Fly   316 CGKTFSLSSSRNAHYYLHSSEKSHKCLMCKKEFRLKHQLTAHEKS 360
            |||:||..|....|...|:.||:::|..|.|.||....|..|.::
Human   401 CGKSFSTGSYLIVHKRTHTGEKTYECKECGKAFRNSSCLRVHVRT 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6808	NP_001247055.1	zf-AD	9..79	CDD:214871	93/305 (30%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		zf-C2H2	255..277	CDD:278523	7/21 (33%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..293	CDD:290200	13/23 (57%)
		C2H2 Zn finger	285..305	CDD:275368	8/19 (42%)
		zf-H2C2_2	299..321	CDD:290200	13/21 (62%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		C2H2 Zn finger	341..359	CDD:275368	7/17 (41%)
ZNF177	NP_001166122.1	KRAB	14..70	CDD:214630
		C2H2 Zn finger	124..142	CDD:275368
		C2H2 Zn finger	150..170	CDD:275368	3/8 (38%)
		C2H2 Zn finger	178..197	CDD:275368	5/22 (23%)
		COG5048	<212..442	CDD:227381	77/245 (31%)
		C2H2 Zn finger	258..278	CDD:275368	5/24 (21%)
		C2H2 Zn finger	286..306	CDD:275368	4/19 (21%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..446	CDD:275368	7/20 (35%)
		zf-H2C2_2	439..463	CDD:404364	2/7 (29%)
		C2H2 Zn finger	454..474	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910