Protein Alignment Zaf1 and ZNF506

DIOPT Version :10

• Sequence 1: NP_731602.1
• Gene: Zaf1 / 41394
• FlyBaseID: FBgn0037921
• Length: 375
• Species: Drosophila melanogaster
• Sequence 2: NP_001092739.1
• Gene: ZNF506 / 440515
• HGNCID: 23780
• Length: 444
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 91/358 - (25%)
• Similarity: 149/358 - (41%)
• Gaps: 88/358 - (24%)

  Fly    12 TCRKKGTQSTLQSLFESNAH-KLLISYAGTSVKPDDGLPDQICTVCLMQLEEVDRFLSACKQSDA 75
            ||.::|.:.......|..|. .::.|:....:..:..:.|....|.|.:.|:       |:.
Human    54 TCLEQGKKPLTMKRHEMIAKPPVMYSHFAQDLWSEQSIKDSFQKVILRRYEK-------CRH--- 108

  Fly    76 HLRSLVRQTLSSASAFETLEDKDQLEQKKRARKQNISGRLIEENPIN---FKTQENALETTK--- 134
                                  |.|:.||....       ::|.|::   :...:..|.||:
Human   109 ----------------------DNLQLKKGCES-------VDECPVHKRGYNGLKQCLATTQRKI 144

  Fly   135 ---DDEILPINKFSSDFVFDLNVNAENEKDIHQEDYTISDMDLDREISDQNYSETYSQESSAATD 196
               |:.:..::|||       |.|....:|..::.:...:           |.:|::|.|:..|
Human   145 FQCDEYVKFLHKFS-------NSNKHKIRDTGKKSFKCIE-----------YGKTFNQSSTRTT- 190

  Fly   197 SIQETSEDYHNLEPSADYVIDLGVACEPDKYRCKICSNTYRCLSQLNAHSQVHRKEKDHQCEVCQ 261
                    |..        ||.|    ..:|:|:.|...|:..|.|..|.::|..||.::||.|.
Human   191 --------YKK--------IDAG----EKRYKCEECGKAYKQSSHLTTHKKIHTGEKPYKCEECG 235

  Fly   262 KTFRAACNLKTHMRTHTGEKPYQCCYCSRRFADNSTHRKHERLHTNERPYACNICGKTFSLSSSR 326
            |.::.:|||.||...|||||||:|..|.:.|...:|...|:::||.|:||.|:.|||.|..||:.
Human   236 KAYKQSCNLTTHKIIHTGEKPYRCRECGKAFNHPATLFSHKKIHTGEKPYKCDKCGKAFISSSTL 300

  Fly   327 NAHYYLHSSEKSHKCLMCKKEFRLKHQLTAHEK 359
            ..|..:|:.||.:||..|.|.|.....||.|::
Human   301 TKHEIIHTGEKPYKCEECGKAFNRSSNLTKHKR 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zaf1	NP_731602.1	zf-AD	9..79	CDD:214871	11/67 (16%)
		SFP1	<161..320	CDD:227516	50/158 (32%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		C2H2 Zn finger	257..277	CDD:275368	9/19 (47%)
		zf-H2C2_2	269..293	CDD:463886	13/23 (57%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		C2H2 Zn finger	313..333	CDD:275368	8/19 (42%)
		C2H2 Zn finger	341..359	CDD:275368	7/17 (41%)
ZNF506	NP_001092739.1	KRAB	4..62	CDD:214630	3/7 (43%)
		C2H2 Zn finger	147..167	CDD:275368	6/26 (23%)
		C2H2 Zn finger	175..195	CDD:275368	6/47 (13%)
		SFP1	<197..248	CDD:227516	19/54 (35%)
		C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	231..251	CDD:275368	9/19 (47%)
		COG5048	<255..417	CDD:227381	32/79 (41%)
		C2H2 Zn finger	259..279	CDD:275368	5/19 (26%)
		C2H2 Zn finger	287..307	CDD:275368	8/19 (42%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368