Protein Alignment Zaf1 and ZNF699

DIOPT Version :10

• Sequence 1: NP_731602.1
• Gene: Zaf1 / 41394
• FlyBaseID: FBgn0037921
• Length: 375
• Species: Drosophila melanogaster
• Sequence 2: NP_940937.1
• Gene: ZNF699 / 374879
• HGNCID: 24750
• Length: 642
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 88/351 - (25%)
• Similarity: 157/351 - (44%)
• Gaps: 72/351 - (20%)

  Fly    72 QSDAHLRSLVRQTLSS------ASAFETLEDKDQLEQKKRARKQNISGRLI--EENPINFKTQEN 128
            :.:..|:::.|:.:..      ...|||     ||:..:....|:|.|..|  |:..:.||..::
Human    72 EQEEDLQTVKRELIQGIFMGEHREGFET-----QLKTNESVASQDICGEKISNEQKIVRFKRNDS 131

  Fly   129 ALETTKDDEILPINKFSSDFVFDLNVNAENEKDIHQEDYTISDMDLDREISDQNY-SETYSQESS 192
            ...:..:::    .....|:     .|..:|:  |..::.:.::   .|..::|. .:|:||..:
Human   132 WFSSLHENQ----ESCGIDY-----QNKSHER--HLRNHMVENI---YECYEENQDGQTFSQVPN 182

  Fly   193 AATDSIQETSE--------------DYHNLEP-------SADYVI-DLG-----VAC-------- 222
              .||::..:|              |:.:|:.       |..|.. :.|     :||
Human   183 --LDSLKRNTEVKSCECHECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAFHFLACFKKHMKTP 245

  Fly   223 -EPDKYRCKICSNTYRCLSQLNAHSQVHRKEKDHQCEVCQKTFRAACNLKTHMRTHTGEKPYQCC 286
             |...|.||.|:..:.|.|...||.::|..:.:::|:.|.|.|..:.:|..|.|.|:|:|||:|.
Human   246 TEEKPYECKECTKAFSCSSFFRAHMKIHIGKTNYECKECGKGFSCSSSLTEHKRIHSGDKPYECK 310

  Fly   287 YCSRRFADNSTHRKHERLHTNERPYACNICGKTFSLSSSRNAHYYLHSSEKSHKCLMCKKEFRLK 351
            .|.:.|:.:|:..||:|:|:.::||.|..|||.||.||....|..:|:.||.::|..|.|.|...
Human   311 ECGKAFSCSSSLSKHKRIHSGDKPYECKECGKAFSSSSHLIIHIRIHTGEKPYECKECGKAFSES 375

  Fly   352 HQLTAH------EKSLAHRLIAKEYS 371
            .:||.|      ||....:...|.|:
Human   376 SKLTVHGRTHTGEKPYKCKECGKAYN 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zaf1	NP_731602.1	zf-AD	9..79	CDD:214871	1/6 (17%)
		SFP1	<161..320	CDD:227516	52/195 (27%)
		C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..293	CDD:463886	10/23 (43%)
		C2H2 Zn finger	285..305	CDD:275368	7/19 (37%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		C2H2 Zn finger	341..359	CDD:275368	7/23 (30%)
ZNF699	NP_940937.1	KRAB	19..79	CDD:214630	1/6 (17%)
		COG5048	<118..326	CDD:227381	49/223 (22%)
		C2H2 Zn finger	143..159	CDD:275368	4/22 (18%)
		C2H2 Zn finger	167..189	CDD:275368	6/23 (26%)
		C2H2 Zn finger	197..217	CDD:275368	2/19 (11%)
		zf-H2C2_2	209..232	CDD:463886	4/22 (18%)
		C2H2 Zn finger	225..245	CDD:275368	3/19 (16%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		COG5048	276..641	CDD:227381	45/126 (36%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..357	CDD:275368	9/19 (47%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		C2H2 Zn finger	393..413	CDD:275368	2/9 (22%)
		C2H2 Zn finger	421..439	CDD:275368
		C2H2 Zn finger	449..469	CDD:275368
		C2H2 Zn finger	477..497	CDD:275368
		C2H2 Zn finger	505..525	CDD:275368
		C2H2 Zn finger	533..553	CDD:275368
		C2H2 Zn finger	561..581	CDD:275368
		C2H2 Zn finger	589..609	CDD:275368
		C2H2 Zn finger	617..637	CDD:275368