DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6808 and ZNF391

DIOPT Version :9

Sequence 1:	NP_001247055.1	Gene:	CG6808 / 41394	FlyBaseID:	FBgn0037921	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001070249.1	Gene:	ZNF391 / 346157	HGNCID:	18779	Length:	358	Species:	Homo sapiens

Alignment Length:	346	Identity:	86/346 - (24%)
Similarity:	140/346 - (40%)	Gaps:	82/346 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 LRSLVRQTLSSASAFETLEDKDQLEQKKRA---RKQNISGRLIEENPINFK---TQENALETTKD 135
            :.||...|....:..|..:::.||.::.:.   :|.:....::.:..:..|   |.|...|
Human     1 MESLRGNTAQGPTNEEDYKNEGQLSRQTKCPAQKKSSFENTVVRKVSVTLKEIFTGEEGPE---- 61

  Fly   136 DEILPINKFSSDFVFDLNVNAE--------------NEKD-----IHQEDYT----ISDMDLDRE 177
                     ||:|....|::|:              |.||     .||..::    ....:.::.
Human    62 ---------SSEFSLSPNLDAQQKIPKGHGSPISRKNSKDNSDLIKHQRLFSQRKPCKCNECEKA 117

  Fly   178 ISDQN----YSETYSQESSAATDSIQET-SEDYHNLEPSADYVIDLGVACEPDKYRCKICSNTYR 237
            .|.|:    :|..:..|.....:...:: |...|.:|....:..:     :|  |.|..|...:.
Human   118 FSYQSDLLVHSRIHGGEKPFECNKCGKSFSRSTHLIEHQRTHTGE-----KP--YECNECGKAFS 175

  Fly   238 CLSQLNAHSQVHRKEKDHQCEVCQKTFRAACNLKTHMRTHTGEKPYQCCYCSRRFADNST---HR 299
            ..:.|:.|.::|..||.::|..|.|.|..:.||..|.||||.|:||:|..|.:.|.|.||   |:
Human   176 RSTHLSLHQRIHTGEKPYECSECGKAFSRSTNLSQHQRTHTQERPYKCNECGKAFGDRSTIIQHQ 240

  Fly   300 K-------------------------HERLHTNERPYACNICGKTFSLSSSRNAHYYLHSSEKSH 339
            :                         |:|.||.|.||.|:.|||.||.|||...|..:||.||.|
Human   241 RIHTGENPYECSKCGKAFSWISSLTEHQRTHTGENPYECSECGKVFSRSSSLTEHQRIHSGEKPH 305

  Fly   340 KCLMCKKEFRLKHQLTAHEKS 360
            :|.:|.|.|.....|..|:::
Human   306 ECRVCGKGFSRSSSLIIHQRT 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6808	NP_001247055.1	zf-AD	9..79	CDD:214871	0/1 (0%)
		C2H2 Zn finger	229..249	CDD:275368	4/19 (21%)
		zf-C2H2	255..277	CDD:278523	8/21 (38%)
		C2H2 Zn finger	257..277	CDD:275368	8/19 (42%)
		zf-H2C2_2	269..293	CDD:290200	12/23 (52%)
		C2H2 Zn finger	285..305	CDD:275368	9/47 (19%)
		zf-H2C2_2	299..321	CDD:290200	11/46 (24%)
		C2H2 Zn finger	313..333	CDD:275368	10/19 (53%)
		C2H2 Zn finger	341..359	CDD:275368	6/17 (35%)
ZNF391	NP_001070249.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..94		10/50 (20%)
		C2H2 Zn finger	111..131	CDD:275368	3/19 (16%)
		zf-H2C2_2	123..148	CDD:290200	2/24 (8%)
		C2H2 Zn finger	139..159	CDD:275368	3/19 (16%)
		zf-H2C2_2	151..176	CDD:290200	6/31 (19%)
		COG5048	<163..340	CDD:227381	58/166 (35%)
		C2H2 Zn finger	167..187	CDD:275368	4/19 (21%)
		zf-H2C2_2	179..204	CDD:290200	9/24 (38%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		zf-H2C2_2	207..230	CDD:290200	12/22 (55%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..259	CDD:290200	1/20 (5%)
		C2H2 Zn finger	251..271	CDD:275368	2/19 (11%)
		zf-H2C2_2	263..288	CDD:290200	12/24 (50%)
		C2H2 Zn finger	279..299	CDD:275368	10/19 (53%)
		zf-H2C2_2	291..316	CDD:290200	11/24 (46%)
		C2H2 Zn finger	307..327	CDD:275368	6/20 (30%)
		zf-H2C2_2	319..342	CDD:290200	2/8 (25%)
		zf-C2H2	333..355	CDD:278523
		C2H2 Zn finger	335..355	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910