Protein Alignment Zaf1 and IKZF2

DIOPT Version :10

• Sequence 1: NP_731602.1
• Gene: Zaf1 / 41394
• FlyBaseID: FBgn0037921
• Length: 375
• Species: Drosophila melanogaster
• Sequence 2: XP_011509104.1
• Gene: IKZF2 / 22807
• HGNCID: 13177
• Length: 533
• Species: Homo sapiens
• Alignment Length: 226
• Identity: 58/226 - (25%)
• Similarity: 95/226 - (42%)
• Gaps: 28/226 - (12%)

  Fly   132 TTKDDEILPINKFSSDFVFDLNVNAENEKDIHQEDYTI---------SDMDLDREISDQNYSETY 187
            |:.|:|:.| .:..|:...||..:..|.:.......|.         ||.:.||:...:......
Human    17 TSGDNELSP-EREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRG 80

  Fly   188 SQESSAATDSIQETSEDYHNLEPSADYVIDL----GVACEPDKYRCKICSNTYRCL--SQLNAHS 246
            ..|.|:..:.:.|:||...|.:     |.:|    |:.....|.:|.:|...  |:  :.|..|.
Human    81 HDEGSSLEEPLIESSEVADNRK-----VQELQGEGGIRLPNGKLKCDVCGMV--CIGPNVLMVHK 138

  Fly   247 QVHRKEKDHQCEVCQKTFRAACNLKTHMRTHTGEKPYQCCYCSRRFADNSTHRKHERLHTNERPY 311
            :.|..|:...|..|..:|....||..|::.|:||||::|.:||...........|.|.|:..:|:
Human   139 RSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPH 203

  Fly   312 ACNICGKTFSLSSSRNAHYYLHSSEKSHKCL 342
            .||.||:::...||...|     .|:.|..|
Human   204 KCNYCGRSYKQRSSLEEH-----KERCHNYL 229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zaf1	NP_731602.1	zf-AD	9..79	CDD:214871
		SFP1	<161..320	CDD:227516	44/173 (25%)
		C2H2 Zn finger	229..249	CDD:275368	5/21 (24%)
		C2H2 Zn finger	257..277	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..293	CDD:463886	11/23 (48%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		C2H2 Zn finger	313..333	CDD:275368	7/19 (37%)
		C2H2 Zn finger	341..359	CDD:275368	1/2 (50%)
IKZF2	XP_011509104.1	C2H2 Zn finger	121..141	CDD:275368	5/21 (24%)
		zf-H2C2_2	134..158	CDD:463886	7/23 (30%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		zf-H2C2_2	161..186	CDD:463886	11/24 (46%)
		C2H2 Zn finger	177..197	CDD:275368	5/19 (26%)
		C2H2 Zn finger	205..226	CDD:275368	8/25 (32%)