DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6808 and ZNF778

DIOPT Version :9

Sequence 1:	NP_001247055.1	Gene:	CG6808 / 41394	FlyBaseID:	FBgn0037921	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001188336.1	Gene:	ZNF778 / 197320	HGNCID:	26479	Length:	757	Species:	Homo sapiens

Alignment Length:	145	Identity:	59/145 - (40%)
Similarity:	81/145 - (55%)	Gaps:	2/145 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 IDLGVACEPDKYRCKICSNTYRCLSQLNAHSQVHRKEKDHQCEVCQKTFRAACNLKTHMRTHTGE 280
            |.:....:|  |.||.|..|:...|.|..|.:.|..||.::|:||.|.|..:.:|..|:||||||
Human   580 IQIHTGIKP--YECKDCGKTFTVSSSLTEHIRTHTGEKPYECKVCGKAFTTSSHLIVHIRTHTGE 642

  Fly   281 KPYQCCYCSRRFADNSTHRKHERLHTNERPYACNICGKTFSLSSSRNAHYYLHSSEKSHKCLMCK 345
            |||.|..|.:.||.:|...:|.|.||.|:||.||.|||.|..||..:.|..:|:.:|.:||..|.
Human   643 KPYICKECGKAFASSSHLIEHRRTHTGEKPYICNECGKAFRASSHLHKHGRIHTGQKPYKCKECG 707

  Fly   346 KEFRLKHQLTAHEKS 360
            |.:...:.|..|.|:
Human   708 KAYNRFYLLKEHLKT 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6808	NP_001247055.1	zf-AD	9..79	CDD:214871
		C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		zf-C2H2	255..277	CDD:278523	8/21 (38%)
		C2H2 Zn finger	257..277	CDD:275368	8/19 (42%)
		zf-H2C2_2	269..293	CDD:290200	13/23 (57%)
		C2H2 Zn finger	285..305	CDD:275368	7/19 (37%)
		zf-H2C2_2	299..321	CDD:290200	12/21 (57%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		C2H2 Zn finger	341..359	CDD:275368	5/17 (29%)
ZNF778	NP_001188336.1	KRAB	42..100	CDD:214630
		C2H2 Zn finger	283..303	CDD:275368
		C2H2 Zn finger	311..331	CDD:275368
		C2H2 Zn finger	339..358	CDD:275368
		C2H2 Zn finger	367..387	CDD:275368
		COG5048	380..747	CDD:227381	59/145 (41%)
		C2H2 Zn finger	395..415	CDD:275368
		C2H2 Zn finger	423..443	CDD:275368
		C2H2 Zn finger	451..471	CDD:275368
		C2H2 Zn finger	479..499	CDD:275368
		C2H2 Zn finger	507..527	CDD:275368
		C2H2 Zn finger	535..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368	1/2 (50%)
		C2H2 Zn finger	591..611	CDD:275368	7/19 (37%)
		C2H2 Zn finger	619..639	CDD:275368	8/19 (42%)
		C2H2 Zn finger	647..667	CDD:275368	7/19 (37%)
		C2H2 Zn finger	675..695	CDD:275368	9/19 (47%)
		C2H2 Zn finger	703..722	CDD:275368	5/18 (28%)
		C2H2 Zn finger	731..751	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910