Protein Alignment Zaf1 and ZNF540

DIOPT Version :10

• Sequence 1: NP_731602.1
• Gene: Zaf1 / 41394
• FlyBaseID: FBgn0037921
• Length: 375
• Species: Drosophila melanogaster
• Sequence 2: NP_689819.1
• Gene: ZNF540 / 163255
• HGNCID: 25331
• Length: 660
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 95/399 - (23%)
• Similarity: 164/399 - (41%)
• Gaps: 81/399 - (20%)

  Fly     6 KWSMCRTCRKKGTQSTLQSLFESNAHKLLISYAGTSVKPD-DGLPDQICTVCLMQLEEVDR---- 65
            :|....|.::|..:..   :.|:..:.:.:.|:|:  ||| ..|.:|....|::..:...|
Human    19 EWECLDTTQRKLYRDV---MLENYNNLVSLGYSGS--KPDVITLLEQGKEPCVVARDVTGRQCPG 78

  Fly    66 FLSACK------QSDAHLRSLVRQTLSSASAFETLEDKDQLEQKKRARKQNISGRLIEENPINFK 124
            .||..|      :.|.|..||.::::              :|:.|..|.:....|...:|...|:
Human    79 LLSRHKTKKLSSEKDIHEISLSKESI--------------IEKSKTLRLKGSIFRNEWQNKSEFE 129

  Fly   125 TQENALETTKDDEILPINKFSSD-----FVFDLNV-NAENEKDIHQEDYTISDMDLDREISDQNY 183
            .|:...|.:...:.:...|.|:|     |..:..: |:|...|.|...:...|.|:..:
Human   130 GQQGLKERSISQKKIVSKKMSTDRKRPSFTLNQRIHNSEKSCDSHLVQHGKIDSDVKHD------ 188

  Fly   184 SETYSQESSAATDSIQETS--EDYHNLEPSADYVIDLGVACEPDK-------------------- 226
                .:|..:..:::.:.:  :..|..|.|          |:.:|
Human   189 ----CKECGSTFNNVYQLTLHQKIHTGEKS----------CKCEKCGKVFSHSYQLTLHQRFHTG 239

  Fly   227 ---YRCKICSNTYRCLSQLNAHSQVHRKEKDHQCEVCQKTFRAACNLKTHMRTHTGEKPYQCCYC 288
               |.|:.|..|:....|||.|.::|..:|.:.|:.|.|.|.:...|..|.|.|||:|.|:|..|
Human   240 EKPYECQECGKTFTLYPQLNRHQKIHTGKKPYMCKKCDKGFFSRLELTQHKRIHTGKKSYECKEC 304

  Fly   289 SRRFADNSTHRKHERLHTNERPYACNICGKTFSLSSSRNAHYYLHSSEKSHKCLMCKKEFRLKHQ 353
            .:.|......::|||:||.::||.|..|||.||:......|..:|:..|.::|..|.|.|||...
Human   305 GKVFQLIFYFKEHERIHTGKKPYECKECGKAFSVCGQLTRHQKIHTGVKPYECKECGKTFRLSFY 369

  Fly   354 LTAHEKSLA 362
            ||.|.::.|
Human   370 LTEHRRTHA 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zaf1	NP_731602.1	zf-AD	9..79	CDD:214871	17/80 (21%)
		SFP1	<161..320	CDD:227516	46/183 (25%)
		C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..293	CDD:463886	10/23 (43%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		C2H2 Zn finger	313..333	CDD:275368	7/19 (37%)
		C2H2 Zn finger	341..359	CDD:275368	9/17 (53%)
ZNF540	NP_689819.1	KRAB	6..66	CDD:214630	11/51 (22%)
		C2H2 Zn finger	189..209	CDD:275368	1/19 (5%)
		C2H2 Zn finger	217..237	CDD:275368	1/19 (5%)
		COG5048	241..620	CDD:227381	51/138 (37%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..405	CDD:275368
		C2H2 Zn finger	413..433	CDD:275368
		C2H2 Zn finger	441..461	CDD:275368
		C2H2 Zn finger	469..489	CDD:275368
		C2H2 Zn finger	497..517	CDD:275368
		C2H2 Zn finger	525..545	CDD:275368
		C2H2 Zn finger	553..573	CDD:275368
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		zf-H2C2_2	621..646	CDD:463886
		C2H2 Zn finger	637..657	CDD:275368