Protein Alignment Zaf1 and ZNF595

DIOPT Version :10

• Sequence 1: NP_731602.1
• Gene: Zaf1 / 41394
• FlyBaseID: FBgn0037921
• Length: 375
• Species: Drosophila melanogaster
• Sequence 2: NP_872330.1
• Gene: ZNF595 / 152687
• HGNCID: 27196
• Length: 648
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 100/385 - (25%)
• Similarity: 149/385 - (38%)
• Gaps: 68/385 - (17%)

  Fly    10 CRTCRKKGTQSTLQSLFESNAHKLLISYAGTSVKPDDGLPDQICTVC--------LMQ---LEEV 63
            |.||.|     .......||.||:    ..|..||..      ||.|        |.|   :...
Human   147 CNTCVK-----VFSKFSNSNKHKI----RHTGEKPFK------CTECGRSFYMSHLTQHTGIHAG 196

  Fly    64 DRFLSACKQSDAHLRSLVRQTLSSASAFETLEDKDQLEQKKRA-RKQNISGRLIEENPIN----- 122
            ::.....|...|..||   .:||......|.|.....|:..:| |:..:   |.|...|:
Human   197 EKPYKCEKCGKAFNRS---TSLSKHKRIHTGEKPYTCEECGKAFRRSTV---LNEHKKIHTGEKP 255

  Fly   123 FKTQENALETTKDDEILPINKFSS----------DFVFDLNVNAENEKDIH--QEDYTISDMDLD 175
            :|.:|.....|:...:....|..:          ...|..:.:....|:||  ::.|...:.
Human   256 YKCEECGKAFTRSTTLNEHKKIHTGEKPYKCKECGKAFRWSTSLNEHKNIHTGEKPYKCKEC--- 317

  Fly   176 REISDQNYSETYSQESSAATDSIQETSEDYHNLE-------PSADYVIDLGVACEPDKYRCKICS 233
                    .:.:.|..|........|.|..:..|       .|:..:|...:..|...|:|:.|.
Human   318 --------GKAFRQSRSLNEHKNIHTGEKPYTCEKCGKAFNQSSSLIIHRSIHSEQKLYKCEECG 374

  Fly   234 NTYRCLSQLNAHSQVHRKEKDHQCEVCQKTFRAACNLKTHMRTHTGEKPYQCCYCSRRFADNSTH 298
            ..:...|.||.|.::|..||.:.||.|.|.|..:.:|..|.|.|||||||.|..|.:.|..:||.
Human   375 KAFTWSSSLNKHKRIHTGEKPYTCEECGKAFYRSSHLAKHKRIHTGEKPYTCEECGKAFNQSSTL 439

  Fly   299 RKHERLHTNERPYACNICGKTFSLSSSRNAHYYLHSSEKSHKCLMCKKEFRLKHQLTAHE 358
            ..|:|:|:.::||.|..|||.|:.|::.|.|..:|:.||.:||..|.|.|.....|..|:
Human   440 ILHKRIHSGQKPYKCEECGKAFTRSTTLNEHKKIHTGEKPYKCEECGKAFIWSASLNEHK 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zaf1	NP_731602.1	zf-AD	9..79	CDD:214871	18/79 (23%)
		SFP1	<161..320	CDD:227516	50/167 (30%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		C2H2 Zn finger	257..277	CDD:275368	8/19 (42%)
		zf-H2C2_2	269..293	CDD:463886	12/23 (52%)
		C2H2 Zn finger	285..305	CDD:275368	7/19 (37%)
		C2H2 Zn finger	313..333	CDD:275368	8/19 (42%)
		C2H2 Zn finger	341..359	CDD:275368	6/18 (33%)
ZNF595	NP_872330.1	KRAB	4..64	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368	8/28 (29%)
		C2H2 Zn finger	175..194	CDD:275368	5/18 (28%)
		COG5048	198..599	CDD:227381	84/319 (26%)
		C2H2 Zn finger	202..222	CDD:275368	6/22 (27%)
		C2H2 Zn finger	230..250	CDD:275368	5/22 (23%)
		C2H2 Zn finger	258..278	CDD:275368	3/19 (16%)
		C2H2 Zn finger	286..306	CDD:275368	2/19 (11%)
		C2H2 Zn finger	314..334	CDD:275368	2/30 (7%)
		C2H2 Zn finger	342..362	CDD:275368	3/19 (16%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..446	CDD:275368	7/19 (37%)
		C2H2 Zn finger	454..474	CDD:275368	8/19 (42%)
		C2H2 Zn finger	482..502	CDD:275368	6/18 (33%)
		C2H2 Zn finger	510..530	CDD:275368
		C2H2 Zn finger	538..558	CDD:275368
		C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368
		zf-H2C2_2	606..631	CDD:463886
		C2H2 Zn finger	622..642	CDD:275368