DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14710 and ZNF397

DIOPT Version :9

Sequence 1:	NP_650092.4	Gene:	CG14710 / 41393	FlyBaseID:	FBgn0037920	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	XP_006722621.1	Gene:	ZNF397 / 84307	HGNCID:	18818	Length:	553	Species:	Homo sapiens

Alignment Length:	422	Identity:	110/422 - (26%)
Similarity:	159/422 - (37%)	Gaps:	99/422 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LGDFEESQMICLFGDKGE------SDLRKKLELCCRIRVRQSPQLPEKACN--SCCEFVQMWFNF 70
            |.|.|..     |.|.|:      ||:.|.:.....:.|..|||.|.....  :|....|...:.
Human   125 LEDLERE-----FDDPGQQVGTEKSDVGKGIYSLEHVMVPASPQGPAVPWKDLTCLRASQESTDI 184

  Fly    71 RQMCLNSQVYWETSSSERPEALAQASDAEYMLYLYENLHLKLGTENQEKEEITAIEEGDEQQEDQ 135
            ....|.:|:     .|.:| .|:..||.                ||.|    ||.:||..:::.|
Human   185 HLQPLKTQL-----KSWKP-CLSPKSDC----------------ENSE----TATKEGISEEKSQ 223

  Fly   136 SQEVLDFNGFIINESIEEDEEPNTESPEQILISHMDSYVDDQQMEELIDDKGELVEELSNANTFY 200
            ..                .:||:...    :..|..:.|..|.     ...||.:...|...:|.
Human   224 GL----------------PQEPSFRG----ISEHESNLVWKQG-----SATGEKLRSPSQGGSFS 263

  Fly   201 EVEYGDEEL----LMSSAPS----PHPSFKMDKQKP-GRPRKPD-AELKFKR-KDINAKER---G 251
            :|.:.::.|    |...|..    ...|....|..| .||.:.| ....||: ..:...:|   |
Human   264 QVIFTNKSLGKRDLYDEAERCLILTTDSIMCQKVPPEERPYRCDVCGHSFKQHSSLTQHQRIHTG 328

  Fly   252 NQP-KCKE--------------------EEKFMCILCGNVFYKKSVFTAHMMTHSEYKPHQCEIC 295
            .:| ||.:                    |:.:.|..||..|.:.|....|...|:..|..:|..|
Human   329 EKPYKCNQCGKAFSLRSYLIIHQRIHSGEKAYECSECGKAFNQSSALIRHRKIHTGEKACKCNEC 393

  Fly   296 NKSFRQMGELRAHIRRHTGDRPYKCMYCDRHFYDRSERVRHERVHTNTRPYACQECGKTFTHTAI 360
            .|:|.|...|..|.|.|||::||:|..|.:.|...|:.:||:|:||..|||.|.||||.|..::.
Human   394 GKAFSQSSYLIIHQRIHTGEKPYECNECGKTFSQSSKLIRHQRIHTGERPYECNECGKAFRQSSE 458

  Fly   361 LKNHILSHSAQKNYNCGICCKSFTLLHQLKAH 392
            |..|...||.:|.|.|..|.|:|:|...|..|
Human   459 LITHQRIHSGEKPYECSECGKAFSLSSNLIRH 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14710	NP_650092.4	zf-AD	9..83	CDD:285071	18/76 (24%)
		COG5048	<261..395	CDD:227381	52/132 (39%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-C2H2	290..312	CDD:278523	8/21 (38%)
		C2H2 Zn finger	292..312	CDD:275368	8/19 (42%)
		zf-H2C2_2	304..327	CDD:290200	10/22 (45%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..357	CDD:290200	14/21 (67%)
		C2H2 Zn finger	348..368	CDD:275368	8/19 (42%)
		C2H2 Zn finger	376..395	CDD:275368	7/17 (41%)
ZNF397	XP_006722621.1	SCAN	46..139	CDD:128708	6/18 (33%)
		SCAN	46..134	CDD:280241	4/13 (31%)
		COG5048	<297..546	CDD:227381	64/194 (33%)
		zf-C2H2	304..326	CDD:278523	4/21 (19%)
		C2H2 Zn finger	306..326	CDD:275368	4/19 (21%)
		zf-H2C2_2	318..342	CDD:290200	5/23 (22%)
		C2H2 Zn finger	334..354	CDD:275368	1/19 (5%)
		zf-H2C2_2	346..371	CDD:290200	5/24 (21%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	374..399	CDD:290200	7/24 (29%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		zf-H2C2_2	402..427	CDD:290200	11/24 (46%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-H2C2_2	431..455	CDD:290200	14/23 (61%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		zf-H2C2_2	458..482	CDD:290200	9/23 (39%)
		C2H2 Zn finger	474..494	CDD:275368	7/17 (41%)
		zf-H2C2_2	486..511	CDD:290200	2/5 (40%)
		C2H2 Zn finger	502..522	CDD:275368
		zf-C2H2	528..550	CDD:278523
		C2H2 Zn finger	530..550	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910